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Daniela S Gerhard et al.
Genome research, 14(10B), 2121-2127 (2004-10-19)
The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random
M H Hetta et al.
Die Pharmazie, 69(2), 92-95 (2014-03-20)
The aim of this work was the estimation of resveratrol content in two successive extracts (EtOAc and MeOH) of peanuts (Arachis hypogaea L.) pericarp of Egypt, by TLC and HPLC methods. Results showed the presence of 3.0 and 0.5 microg/mL
Boyuan Song et al.
Ultramicroscopy, 203, 145-154 (2019-02-11)
Direct electron detectors are an essential asset for the resolution revolution in electron cryo microscopy of biological objects. The direct detectors provide two modes of data acquisition; the counting mode in which single electrons are counted, and the integrating mode
Weixing Dai et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 29(3), 303-309 (2013-05-07)
To establish the yeast-based bioassay system for the androgenic endocrine disruptors in the environment. The recombinant gene-transformed yeast cells were constructed based on two episomal vectors. In the expression vector, the expression of androgen receptor (AR) gene was driven by
Reciprocal regulation of pH 6 antigen gene loci by PhoP and RovA in Yersinia pestis biovar Microtus.
Yiquan Zhang et al.
Future microbiology, 8(2), 271-280 (2013-02-05)
To explore the transcriptional regulation of the psaEF and psaABC loci by the RovA and PhoP regulators in Yersinia pestis. Primer extension, LacZ fusion, gel mobility shift and DNase I footprinting assays were conducted in combination for this gene regulation
Anca D Petrescu et al.
Protein expression and purification, 58(2), 184-193 (2008-01-08)
Acyl coenzyme A binding protein (ACBP) has been proposed to transport fatty acyl CoAs intracellularly, facilitating their metabolism. In this study, a new mouse recombinant ACBP was produced by insertion of a histidine (his) tag at the C-terminus to allow
Yutaka Tatano et al.
The journal of medical investigation : JMI, 53(1-2), 103-112 (2006-03-16)
The human GLB1 gene encodes a lysosomal beta-galactosidase (beta-Gal) and an elastin-binding protein (EBP). Defect of the EBP as a chaperon for tropoelastin and a component of receptor complex among neuraminidase-1 (NEU1) and protective protein/cathepsin A (PPCA) is suggested responsible
Y Yamamoto et al.
DNA and cell biology, 9(2), 119-127 (1990-03-01)
A lambda gt11 human testicular cDNA library was screened with degenerate oligonucleotide probe mixtures based on amino acid sequence data generated from cyanogen bromide fragments and tryptic fragments of purified human beta-galactosidase. Six positive clones were identified after screening 2
E Paschke et al.
Human genetics, 109(2), 159-166 (2001-08-21)
An inherited deficiency in beta-galactosidase can result in GM1 gangliosidosis, with several phenotypes of generalized or chronic psychomotor deterioration, as well as in Morquio disease type B, a characteristic mucopolysaccharidosis free of neurological symptoms. We performed mutation analyses in 17
Yu Qian et al.
Development (Cambridge, England), 140(8), 1751-1761 (2013-03-28)
Peritubular myoid cells (PMCs) are myofibroblast-like cells that surround the seminiferous tubules and play essential roles in male fertility. How these cells modulate spermatogenesis and the signaling pathways that are involved are largely unknown. Here we report that Lgr4 is
Arun Azad et al.
International journal of radiation oncology, biology, physics, 88(2), 385-394 (2014-01-15)
To examine the effects of combined blockade of DNA-dependent protein kinase (DNA-PK) and poly(adenosine diphosphate-ribose) polymerase-1 (PARP-1) on accelerated senescence in irradiated H460 and A549 non-small cell lung cancer cells. The effects of KU5788 and AG014699 (inhibitors of DNA-PK and
Han Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(46), 18555-18560 (2013-10-30)
The tongue is a critical element of the feeding system in tetrapod animals for their successful adaptation to terrestrial life. Whereas the oral part of the mammalian tongue contains soft tissues only, the avian tongue has an internal skeleton extending
Assays for bacterial mucin-desulfating sulfatases.
A M Roberton et al.
Methods in molecular biology (Clifton, N.J.), 125, 417-426 (2000-05-23)
Radhika Dixit et al.
Development (Cambridge, England), 140(21), 4398-4406 (2013-10-17)
Recent studies have shown that mesothelial progenitors contribute to mesenchymal lineages of developing organs. To what extent the overlying mesothelium contributes to lung development remains unknown. To rigorously address this question, we employed Wt1(CreERT2/+) mice for high-fidelity lineage tracing after
Juan Antonio Marchal et al.
Drug design, development and therapy, 7, 1301-1313 (2013-11-07)
Bozepinib [(RS)-2,6-dichloro-9-[1-(p-nitrobenzenesulfonyl)-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]-9H-purine] is a potent antitumor compound that is able to induce apoptosis in breast cancer cells. In the present study, we show that bozepinib also has antitumor activity in colon cancer cells, showing 50% inhibitory concentration (IC50) values lower
Kathryn K Bercury et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(13), 4466-4480 (2014-03-29)
During CNS development, oligodendrocytes, the myelinating glia of the CNS, progress through multiple transitory stages before terminating into fully mature cells. Oligodendrocyte differentiation and myelination is a tightly regulated process requiring extracellular signals to converge to elicit specific translational and
Urs Lewandrowski et al.
Molecular & cellular proteomics : MCP, 5(2), 226-233 (2005-11-03)
Among known platelet proteins, a prominent and functionally important group is represented by glycoprotein isoforms. They account e.g. for secretory proteins and plasma membrane receptors including integrins and glycoprotein VI as well as intracellular components of cytosol and organelles including
Yasir Hasan Siddique et al.
Journal of insect science (Online), 12, 92-92 (2013-02-23)
In the present study the effect of 0.1, 0.2, 0.4, 0.8, and 1.0 µL/mL of the steroid K-canrenoate was evaluated in the third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ) Bg(9) for 6, 24, and 48 hours of duration. The
Alexandra Moores et al.
Journal of bacteriology, 196(1), 148-156 (2013-10-29)
The phase variation (reversible on-off switching) of the type 1 fimbrial adhesin of Escherichia coli involves a DNA inversion catalyzed by FimB (switching in either direction) or FimE (on-to-off switching). Here, we demonstrate that RfaH activates expression of a FimB-LacZ
Zachary C Ryan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(15), 6199-6204 (2013-03-27)
Inactivating mutations of the SOST (sclerostin) gene are associated with overgrowth and sclerosis of the skeleton. To determine mechanisms by which increased amounts of calcium and phosphorus are accreted to enable enhanced bone mineralization in the absence of sclerostin, we
Purification and properties of a beta-hexosidase from Sporobolomyces singularis.
J A Blakely et al.
Canadian journal of biochemistry, 47(11), 1021-1025 (1969-11-01)
Emmanuel Roze et al.
Movement disorders : official journal of the Movement Disorder Society, 20(10), 1366-1369 (2005-06-30)
GM1 gangliosidosis is due to beta-galactosidase deficiency. Only patients with type 3 disease survive into adulthood and develop movement disorders. Clinical descriptions of this form are rare, particularly in non-Japanese patients. We describe four new patients and systematically analyze all
Edgar Rodríguez-Negrete et al.
Methods in molecular biology (Clifton, N.J.), 1072, 241-258 (2013-10-19)
The yeast two-hybrid system is currently one of the most standardized protein interaction mapping techniques. The rationale of the yeast two-hybrid system relies on the physical separation of the DNA-binding domain from the transcriptional activation domain of several transcription factors.
N G Asp et al.
The Biochemical journal, 114(2), 351-359 (1969-09-01)
1. Two beta-galactosidases from human small-intestinal mucosa were separated by gel-filtration chromatography and the properties of the two enzymes were studied. Lactose and four hetero beta-galactosides were used as substrates. 2. One of the enzymes was particle-bound and could be
Jennifer M Stratford et al.
PloS one, 9(9), e107238-e107238 (2014-09-06)
Fos-Tau-LacZ (FTL) transgenic mice are used to visualize the anatomical connectivity of neurons that express c-Fos, an immediate early gene, in response to activation. In contrast to typical c-Fos protein expression, which is localized to the nucleus of stimulated neurons
L Gort et al.
Clinical genetics, 72(2), 109-111 (2007-07-31)
The term 'pseudodeficiency' is used in lysosomal storage diseases to denote the situation in which individuals show greatly reduced enzyme activity but remain clinically healthy. Pseudodeficiencies have been reported for several lysosomal hydrolases. GM1 gangliosidosis is a rare autosomal recessive
Y He et al.
Cell proliferation, 46(6), 644-653 (2014-01-28)
Many studies have demonstrated that the clock gene, brain and muscle ARNT-like 1 (Bmal1), is directly related to bone ageing by affecting age-related changes to mesenchymal stem cells (MSCs). As a main developmental signal, Wnt may play an important role
Anna Caciotti et al.
Human genetics, 113(1), 44-50 (2003-03-20)
We report the modulating action of the L436F new polymorphism identified in the GLB1 gene of a patient affected by GM1 gangliosidosis with onset at 17 months and rapidly progressive psychomotor deterioration. Sequencing analysis and familial restriction studies revealed that
Elena Piegari et al.
Basic research in cardiology, 108(2), 334-334 (2013-02-16)
The increasing population of cancer survivors faces considerable morbidity and mortality due to late effects of the antineoplastic therapy. Cardiotoxicity is a major limiting factor of therapy with doxorubicin (DOXO), the most effective anthracycline, and is characterized by a dilated
Hongmarn Park et al.
Nucleic acids research, 41(6), 3787-3804 (2013-02-09)
An artificial small RNA (afsRNA) scaffold was designed from an Escherichia coli sRNA, SibC. Using the lacZ reporter system, the gene silencing effects of afsRNAs were examined to explore the sRNA-mediated gene-silencing mechanisms in E. coli. Substitution of the original
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