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Kurinchi Selvan Gurusamy et al.
The Cochrane database of systematic reviews, 12(12), CD010640-CD010640 (2015-01-01)
Anaemia affects about a quarter of the world's population. An estimated 50% of anaemic people have anaemia due to iron deficiency. To assess the safety and efficacy of iron therapies for the treatment of adults with anaemia who are not
B Clevenger et al.
Anaesthesia, 70 Suppl 1, 20-28 (2014-12-03)
Pre-operative anaemia is a relatively common finding, affecting a third of patients undergoing elective surgery. Traditionally associated with chronic disease, management has historically focused on the use of blood transfusion as a solution for anaemia in the peri-operative period. Data
Parenteral iron as a cause of hypophosphataemia.
Francisco J Fernández-Fernández et al.
BMJ (Clinical research ed.), 349, g4616-g4616 (2014-07-17)
Tim M Conway et al.
Nature, 511(7508), 212-215 (2014-07-11)
Dissolved iron is an essential micronutrient for marine phytoplankton, and its availability controls patterns of primary productivity and carbon cycling throughout the oceans. The relative importance of different sources of iron to the oceans is not well known, however, and
Joseph E Kiss et al.
JAMA, 313(6), 575-583 (2015-02-11)
Although blood donation is allowed every 8 weeks in the United States, recovery of hemoglobin to the currently accepted standard (12.5 g/dL) is frequently delayed, and some donors become anemic. To determine the effect of oral iron supplementation on hemoglobin
Eunna Choi et al.
Infection and immunity, 82(6), 2203-2210 (2014-03-20)
In order to survive inside macrophages, Salmonella produces a series of proteins encoded by genes within Salmonella pathogenicity island 2 (SPI-2). In the present study, we report that Fur, a central regulator of iron utilization, negatively controls the expression of
Zille Rubab et al.
Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 26(1), 19-25 (2015-01-13)
Patients on hemodialysis (HD) are usually anemic because of defective erythropoeisis. Hepcidin is a polypeptide that regulates iron homeostasis and could serve as an indicator of functional iron deficiency in patients with end-stage renal disease (ESRD); this may also aid
Mak A Saito et al.
Science (New York, N.Y.), 345(6201), 1173-1177 (2014-09-06)
Marine primary productivity is strongly influenced by the scarcity of required nutrients, yet our understanding of these nutrient limitations is informed by experimental observations with sparse geographical coverage and methodological limitations. We developed a quantitative proteomic method to directly assess
Tea Romih et al.
The Science of the total environment, 508, 76-84 (2014-12-02)
The aim of this study was to determine whether citric acid adsorbed onto cobalt ferrite (CoFe2O4) nanoparticles (NPs) influences the bioavailability of their constituents Co and Fe. Dissolution of Co and Fe was assessed by two measures: (i) in aqueous
Biotechnology: Against the grain.
Michael Eisenstein
Nature, 514(7524), S55-S57 (2014-11-05)
Samer R Abulateefeh et al.
Pharmaceutical development and technology, 19(7), 856-867 (2013-09-17)
The excellent gelling and safety profiles of alginic acid combined, however, with drawbacks of its ionotropically crosslinked beads (i.e. their quick release of loaded drugs) prompted us to chemically modify alginic acid. Alginic acid was chemically conjugated with four amines
William E Winter et al.
Laboratory medicine, 45(2), 92-102 (2014-05-30)
Iron is one of the most important nonorganic substances that make life possible. Iron plays major roles in oxygen transport (eg, hemoglobin; -67% of total body iron [TBI]), short-term oxygen storage (eg, myoglobin; -3.5% of TBI), and energy generation (eg
Carmen S D Rodrigues et al.
Environmental technology, 35(9-12), 1307-1319 (2014-04-08)
This study aims to investigate the efficiency of individual and integrated processes applied to organic matter abatement and biodegradability improvement of a polyester dyeing wastewater, namely coagulation/flocculation combined with Fenton's reagent (Approach 1), Fenton oxidation alone (Approach 2) and its
Sandro Silva-Gomes et al.
Frontiers in cellular and infection microbiology, 3, 96-96 (2013-12-25)
Due to their chemical versatility, transition metals were incorporated as cofactors for several basic metabolic pathways in living organisms. This same characteristic makes them potentially harmful, since they can be engaged in deleterious reactions like Fenton chemistry. As such, organisms
Magnus Steigedal et al.
Journal of immunology (Baltimore, Md. : 1950), 193(12), 6081-6089 (2014-11-16)
Competition for iron is a critical component of successful bacterial infections, but the underlying in vivo mechanisms are poorly understood. We have previously demonstrated that lipocalin 2 (LCN2) is an innate immunity protein that binds to bacterial siderophores and starves
Nosratola D Vaziri
Nephrology news & issues, 28(2), 4-5 (2014-03-22)
Loss of blood associated with hemodialysis procedures and laboratory testing, together with impaired iron absorption due to elevation of hepcidin, invariably cause iron deficiency in end-stage renal disease patients. For this reason, nearly all ESRD patients require intravenous iron to
Matthew Stroh et al.
Biochemical pharmacology, 88(4), 573-583 (2013-12-24)
A popular, if not centric, approach to the study of an event is to first consider that of the simplest cause. When dissecting the underlying mechanisms governing idiopathic diseases, this generally takes the form of an ab initio genetic approach.
Robert F Anderson et al.
Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 372(2019), 20130054-20130054 (2014-06-04)
Fluxes of lithogenic material and fluxes of three palaeo-productivity proxies (organic carbon, biogenic opal and alkenones) over the past 100,000 years were determined using the (230)Th-normalization method in three sediment cores from the Subantarctic South Atlantic Ocean. Features in the
Shee Chien Yong et al.
Science (New York, N.Y.), 345(6201), 1170-1173 (2014-09-06)
Alkaline phosphatases play a crucial role in phosphate acquisition by microorganisms. To expand our understanding of catalysis by this class of enzymes, we have determined the structure of the widely occurring microbial alkaline phosphatase PhoX. The enzyme contains a complex
Don-Kyu Kim et al.
Nature medicine, 20(4), 419-424 (2014-03-25)
In response to microbial infection, expression of the defensin-like peptide hepcidin (encoded by Hamp) is induced in hepatocytes to decrease iron release from macrophages. To elucidate the mechanism by which Salmonella enterica var. Typhimurium (S. typhimurium), an intramacrophage bacterium, alters
Goldie Y L Lui et al.
Molecular pharmacology, 87(3), 543-560 (2015-01-07)
Pharmacologic manipulation of metal pools in tumor cells is a promising strategy for cancer treatment. Here, we reveal how the iron-binding ligands desferrioxamine (DFO), di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC) inhibit constitutive and interleukin 6-induced activation of signal transducer and
Microcytic anemia.
Shraga Aviner et al.
The New England journal of medicine, 371(26), 2536-2536 (2014-12-30)
Ocean chemistry: Fingerprints of a trace nutrient.
Joseph A Resing et al.
Nature, 511(7508), 164-165 (2014-07-11)
Joseph Marie Sieliechi et al.
Environmental technology, 35(13-16), 1831-1839 (2014-06-25)
In this study, spatial and seasonal variations of phosphorus fractions in Lake Bini sediments were evaluated using a sequential extraction method. The sampling of water and sediments (surface and coring) was carried out at seven sites around the lake during
Ocean Science. Microbial proteins and oceanic nutrient cycles.
C Mark Moore
Science (New York, N.Y.), 345(6201), 1120-1121 (2014-09-06)
Femkje A M Jonker et al.
Journal of clinical pathology, 67(8), 717-723 (2014-06-12)
Iron deficiency is an important child health problem. Its diagnosis in areas of high infection exposure remains complicated as inflammation may interfere with the accuracy of peripheral iron markers. With this study, we aimed to validate the conventional iron markers
Hypoferremia of infection: a double-edged sword?
Kristen L Lokken et al.
Nature medicine, 20(4), 335-337 (2014-04-09)
Yu Wang et al.
Biochimica et biophysica acta, 1840(10), 3022-3033 (2014-07-06)
The neurodegenerative disease Friedreich's ataxia is the result of frataxin deficiency. Frataxin is a mitochondrial protein involved in iron-sulfur cluster (Fe-S) cofactor biogenesis, but its functional role in this pathway is debated. This is due to the interconnectivity of iron
Judith Ernst et al.
Food and nutrition bulletin, 35(4 Suppl), S198-S204 (2015-02-03)
Preliminary evidence suggests that improved nutrition early in HIV infection may delay progression to AIDS and delay the initiation or improve the effectiveness of antiretroviral drug therapy. There are few studies that evaluate food-based interventions in drug-naïve, HIV-infected women and
Isabelle R Miousse et al.
Radiation research, 182(1), 92-101 (2014-06-25)
There is an increasing need to better understand the long-term health effects of high-linear energy transfer (LET) radiation due to exposure during space missions, as well as its increasing use in clinical treatments. Previous studies have indicated that exposure to
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