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N Yousaf et al.
Clinical and experimental immunology, 180(2), 289-304 (2014-12-30)
Endoplasmic reticulum aminopeptidase 1 (ERAP1) processes peptides for major histocompatibility complex (MHC) class I presentation and promotes cytokine receptor ectodomain shedding. These known functions of ERAP1 may explain its genetic association with several autoimmune inflammatory diseases. In this study, we
Derek C Marshall et al.
PloS one, 10(5), e0127063-e0127063 (2015-05-12)
Expression of matrix metalloproteinase 9 (MMP9) is elevated in a variety of inflammatory and oncology indications, including ulcerative colitis and colorectal cancer. MMP9 is a downstream effector and an upstream mediator of pathways involved in growth and inflammation, and has
Laura T Donlin et al.
Journal of immunology (Baltimore, Md. : 1950), 193(5), 2373-2383 (2014-07-25)
Mesenchymal stromal cells have emerged as powerful modulators of the immune system. In this study, we explored how the human macrophage response to TNF is regulated by human synovial fibroblasts, the representative stromal cell type in the synovial lining of
Aleksandra M Dudek-Perić et al.
Cancer research, 75(8), 1603-1614 (2015-03-13)
Systemic chemotherapy generally has been considered immunosuppressive, but it has become evident that certain chemotherapeutic drugs elicit immunogenic danger signals in dying cancer cells that can incite protective antitumor immunity. In this study, we investigated whether locoregionally applied therapies, such
Simone Fuchs et al.
Journal of cellular and molecular medicine, 19(5), 1021-1032 (2015-03-11)
Haemanthus coccineus extracts (HCE) have traditionally been used to treat a variety of diseases, like febrile colds or asthma. Since new therapeutic options against inflammatory processes are still urgently needed, we aimed to pharmacologically characterise the anti-inflammatory potential of HCEin
Hyunjae Lee et al.
Biomicrofluidics, 8(5), 054102-054102 (2014-10-22)
Understanding the mechanism behind cancer metastasis is a major challenge in cancer biology. Several in vitro models have been developed to mimic a cancer microenvironment by engineering cancer-endothelial cell (EC) and cancer-stromal cell interactions. It has been challenging to realistically
Qunli Wang et al.
Bioengineered, 12(2), 12812-12820 (2021-12-14)
Osteoarthritis (OA) is a cartilage degenerative disease commonly observed in the elderly population and significantly impacts the normal life of OA patients. It has been reported that the development of pathological cell senescence in chondrocytes is involved in the pathogenesis
Jingru Huangfu et al.
Cell death & disease, 12(4), 386-386 (2021-04-11)
The present study aims to understand the mechanism of the lens epithelial cell's strong anti-apoptotic capacity and survival in the mature human lens that, on the one hand, maintains lens transparency over several decades, while on the other hand, increases
Kevin Wilhelmsen et al.
Science signaling, 8(391), ra86-ra86 (2015-08-27)
Inflammatory critical illness is a syndrome that is characterized by acute inflammation and organ injury, and it is triggered by infections and noninfectious tissue injury, both of which activate innate immune receptors and pathways. Although reports suggest an anti-inflammatory role
Vitaliy O Kaminskyy et al.
Cancers, 13(5) (2021-03-07)
Ephrin (EFN)/ Erythropoietin-producing human hepatocellular receptors (Eph) signaling has earlier been reported to regulate non-small cell lung cancer (NSCLC) cell survival and cell death as well as invasion and migration. Here, the role of Ephrin type-A receptor 2 (EphA2) on
Koichi Shimizu et al.
Human vaccines & immunotherapeutics, 10(4), 970-976 (2014-01-15)
The recurrence rate after surgery in patients with hepatocellular carcinoma (HCC) is very high, while prognosis is quite poor. However, there is no standard treatment to prevent recurrence of HCC after a curative operation. In this study, we investigated the
Marcela Cataldi et al.
Virology, 485, 340-354 (2015-09-04)
Vesicular stomatitis virus (VSV) is an effective oncolytic virus against most human pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to oncolytic VSV-ΔM51 infection. To better understand the mechanism of resistance, we tested a
Juhee Jeon et al.
Biochemical pharmacology, 89(4), 515-525 (2014-04-17)
The ligation of interleukin-1 receptor (IL-1R) or tumor necrosis factor receptor 1 (TNFR1) induces the recruitment of adaptor proteins and their concomitant ubiquitination to the proximal receptor signaling complex, respectively. Such are upstream signaling events of IKK that play essential
Yong-Deok Jeon et al.
BMC complementary and alternative medicine, 15, 196-196 (2015-06-25)
Ixeris dentata Nakai has been used for the treatment of mithridatism, calculous, indigestion, pneumonia, hepatitis, and tumors in Korea, China, and Japan. However, the effect of a water extract of Ixeris dentata (ID) and its molecular mechanism on allergic inflammation
Hugo Brito et al.
PloS one, 10(5), e0126891-e0126891 (2015-05-30)
A guanine-rich strand within the promoter of the KRAS gene can fold into an intra-molecular G-quadruplex structure (G4), which has an important role in the regulation of KRAS transcription. We have previously identified indolo[3,2-b]quinolines with a 7-carboxylate group and three
Victor H Ferreira et al.
The Journal of infectious diseases, 211(11), 1745-1756 (2014-12-30)
Although clinical and experimental evidence indicates that female sex hormones and hormonal contraceptives regulate susceptibility to human immunodeficiency virus type 1 (HIV-1) infection, the underlying mechanism remains unknown. Genital epithelial cells (GECs) are the first cells to encounter HIV during
Slava Rom et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 35(12), 1957-1965 (2015-07-02)
Pathologic conditions in the central nervous system, regardless of the underlying injury mechanism, show a certain level of blood-brain barrier (BBB) impairment. Endothelial dysfunction is the earliest event in the initiation of vascular damage caused by inflammation due to stroke
Ofra Malka Ohana et al.
Cancer biology & therapy, 16(11), 1651-1659 (2015-09-30)
Hodgkin's lymphoma is believed to spread in an orderly fashion within the lymphatic compartment. In a minority of cases, after reaching the spleen, the neoplasm disseminates, reminiscent of metastasis. In the spleen, the Hodgkin-Reed-Sternberg tumor cells come across platelets in
S Cristofanon et al.
Cell death & disease, 6, e1724-e1724 (2015-04-17)
This study aims at evaluating the combination of the tumor-necrosis-factor-related apoptosis-inducing ligand (TRAIL)-receptor 2 (TRAIL-R2)-specific antibody Drozitumab and the Smac mimetic BV6 in preclinical glioblastoma models. To this end, the effect of BV6 and/or Drozitumab on apoptosis induction and signaling
Zongbo Wei et al.
Free radical biology & medicine, 167, 94-108 (2021-03-17)
Age-related cataracts (ARC) are the primary cause of blindness worldwide, and oxidative stress is considered the central pathogenesis of age-related cataractogenesis. Interestingly, ample evidence suggests that there is no remarkable apoptosis present in aged and cataractous human lenses despite the
Human adipose microRNA-221 is upregulated in obesity and affects fat metabolism downstream of leptin and TNF-α
Meerson A, et al.
Diabetologia, 56, 1971-1979 (2013)
Lan Li et al.
PloS one, 10(4), e0123045-e0123045 (2015-04-23)
Monocyte chemoattractant protein-1 (MCP-1) is a pivotal chemokine in the inflammatory response, which plays an important role in recruiting monocytes to sites of injury and infection. However, the exact mechanism of Mcp-1 associated with PCOS risk was unknown. In this
Chizuko Yano et al.
Annals of dermatology, 27(2), 152-156 (2015-04-04)
CC chemokine ligand 17 (CCL17) and CCL22 are the functional ligands for CCR4. We previously reported that inhibitors of nuclear factor-kappa B and p38 mitogen-activated protein kinase (p38 MAPK), but not of extracellular signal-related kinase (ERK), inhibited tumor necrosis factor
Hideyuki Konishi et al.
Cancer science, 106(5), 542-549 (2015-03-05)
Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide (NAD(+) )-dependent protein deacetylase. In mice, mSirt1 deficiency causes the onset of fatty liver via regulation of the hepatic nutrient metabolism pathway. In this study, we demonstrate SIRT1 expression, activity
Suman Kanji et al.
Stem cell research, 12(1), 275-288 (2013-12-11)
Nanofiber-expanded human umbilical cord blood-derived CD34+ cell therapy is under consideration for treating peripheral and cardiac ischemia. However, the therapeutic efficacy of nanofiber-expanded human umbilical cord blood-derived (NEHUCB) CD34+ cell therapy for wound healing and its mechanisms are yet to
Qiong Xue et al.
Science signaling, 8(381), ra59-ra59 (2015-06-18)
Macrophages not only produce multiple cytokines but also respond to multiple cytokines, which likely shapes the ultimate response of the population. To determine the role of paracrine signaling in shaping the profile of inflammatory cytokines secreted by macrophages in response
C-reactive protein enhances activation of coagulation system and inflammatory response through dissociating into monomeric form in antineutrophil cytoplasmic antibody-associated vasculitis
Xu PC, et al.
BMC Immunology, 16.1 (2015)
Brendan A S McIntyre et al.
Innate immunity, 21(5), 504-511 (2014-09-30)
The acquisition of innate immune response is requisite to having bona fide differentiation of airway epithelium. Procedures developed to differentiate lung airway from human pluripotent stem cells (hPSCs) have demonstrated anecdotal evidence for innate immune response, but an in-depth exploration
Polyxeni Alexiou et al.
Archiv der Pharmazie, 347(11), 798-805 (2014-08-28)
SPD-304 was discovered as a promising tumor necrosis factor alpha (TNF) antagonist that promotes dissociation of TNF trimers and therefore blocks the interaction of TNF and its receptor. However, SPD-304 contains a potentially toxic 3-alkylindole moiety, which can be bioactivated
Chandra S Boosani et al.
Molecular biology reports, 42(9), 1365-1376 (2015-06-07)
Previously we found decreased expression of SOCS3 in neointimal hyperplastic region following balloon angioplasty in atherosclerotic micro swine. In our recent in vitro studies using human coronary artery smooth muscle cells (HCASMC), we observed the inhibition of SOCS3 expression in
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