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H8916
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K Mizrahi et al.
Bone marrow transplantation, 49(7), 942-949 (2014-04-30)
The influence of TNF-α and Fas-ligand (FasL) on viability and function was evaluated in fresh- and expanded-umbilical cord blood (UCB) cells. CD34(+) progenitors and T cells display outstanding survival, whereas ~30% and >50% B lymphocytes and myeloid cells undergo spontaneous
Rupsha Fraser et al.
Journal of reproductive immunology, 110, 54-60 (2015-05-26)
Decidual NK (dNK) cells are present during uterine spiral artery remodelling, an event that is crucial for successful placentation and the provision of an adequate blood supply to the developing fetus. Spiral artery remodelling is impaired in the pregnancy complication
David Jungck et al.
The Journal of pharmacology and experimental therapeutics, 353(3), 564-572 (2015-04-10)
Evidence is lacking on the differential effects of the two therapeutic concepts of endothelin receptor antagonists (ERAs): the blockade of only the endothelin receptor A (ETAR; selective antagonism) versus both ETAR and endothelin receptor B (ETBR; dual blockade). Ambrisentan, a
Mi Sook Jeong et al.
Annals of dermatology, 26(3), 296-302 (2014-06-27)
Although vitamin D analogs have been used in the topical treatment of psoriasis, their mechanisms of action are not well understand. Calcitriol, the hormonally active vitamin D3 metabolite, has been demonstrated to exert immunomodulatory effects in the skin by down-regulating
Ashley R Maiuri et al.
Toxicological sciences : an official journal of the Society of Toxicology, 146(2), 265-280 (2015-05-09)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most frequent causes of idiosyncratic, drug-induced liver injury (IDILI). Mechanisms of IDILI are unknown, but immune responses are suspected to underlie them. In animal models of IDILI, the cytokines tumor necrosis factor-alpha (TNFα)
Endogenous myeloperoxidase is a mediator of joint inflammation and damage in experimental arthritis.
Dragana Odobasic et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(4), 907-917 (2014-04-24)
Myeloperoxidase (MPO) is implicated as a local mediator of tissue damage when released extracellularly in many chronic inflammatory diseases. The purpose of this study was to explore the role of endogenous MPO in experimental rheumatoid arthritis (RA). K/BxN serum-transfer arthritis
Hasitha Gunawardana et al.
Scientific reports, 11(1), 1949-1949 (2021-01-23)
Endothelial cells (EC) coordinate vascular homeostasis and inflammation. In organ transplantation, EC are a direct alloimmune target. We posited that tissue specific heterogeneity of vascular EC may partly underlie the disparate organ-specific alloimmune risk. We examined the vascular endothelial response
Jun Liu et al.
PloS one, 9(4), e94912-e94912 (2014-04-12)
Cysteine-rich 61/connective tissue growth factor/nephroblastoma overexpressed (CCN) 3 has been recently reported to play a role in regulating inflammation of vascular endothelial cells. However, the role of CCN3 in atherosclerosis, which is characterized by vascular inflammation, remains unclear. Overexpression of
F Tamarozzi et al.
Parasite immunology, 36(10), 494-502 (2014-06-10)
The host inflammatory response to the Onchocerca volvulus endosymbiont, Wolbachia, is a major contributing factor in the development of chronic pathology in humans (onchocerciasis/river blindness). Recently, the toll-like pattern recognition receptor motif of the major inflammatory ligands of filarial Wolbachia
Mefunidone attenuates tubulointerstitial fibrosis in a rat model of unilateral ureteral obstruction.
Chunyan Liu et al.
PloS one, 10(6), e0129283-e0129283 (2015-06-05)
Inflammation has a crucial role in renal interstitial fibrosis, which is the common pathway of chronic kidney diseases. Mefunidone (MFD) is a new compound which could effectively inhibit the proliferation of renal fibroblasts in vitro. However, the overall effect of
Xiaoying Tian et al.
International journal of clinical and experimental pathology, 8(5), 4933-4942 (2015-07-21)
Emerging evidence showed that miRNA dysregulation is involved in the development of endometriosis and may contribute to pathological process of endometriosis associated ovarian cancer (EAOC). miR-191 is one of the most differentially expressed miRNAs in pairwise comparisons among healthy controls
Markers of endothelial dysfunction in patients with non-alcoholic fatty liver disease and coronary artery disease.
Elzafir Elsheikh et al.
Journal of gastroenterology and hepatology, 29(7), 1528-1534 (2015-01-15)
Yue Zhou et al.
Nature communications, 6, 7679-7679 (2015-07-15)
Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been
Aravind T Reddy et al.
Life sciences, 258, 118136-118136 (2020-07-30)
The endothelium is a critical regulator of vascular homeostasis, controlling vascular tone and permeability as well as interactions of leukocytes and platelets with blood vessel walls. Consequently, endothelial dysfunction featuring inflammation and reduced vasodilation are considered central to cardiovascular disease
Eun-Jin Lee et al.
Journal of cellular physiology, 229(11), 1744-1752 (2014-03-26)
Pentraxin-3 (PTX3), also known as tumor necrosis factor-stimulated gene 14 (TSG-14), is produced by immune and vascular cells in response to pro-inflammatory signals and is therefore a multipotent inflammatory mediator. The present study showed that during human osteoblast (OB) differentiation
Matilde Alique et al.
Clinical science (London, England : 1979), 127(1), 19-31 (2014-01-05)
ILK (integrin-linked kinase) is an intracellular serine/threonine kinase involved in cell-matrix interactions. ILK dysregulation has been described in chronic renal disease and modulates podocyte function and fibrosis, whereas data about its role in inflammation are scarce. AngII (angiotensin II) is
Richard L Watson et al.
The Journal of experimental medicine, 212(7), 1021-1041 (2015-06-24)
CD99 is a critical regulator of leukocyte transendothelial migration (TEM). How CD99 signals during this process remains unknown. We show that during TEM, endothelial cell (EC) CD99 activates protein kinase A (PKA) via a signaling complex formed with the lysine-rich
Audra A Winder et al.
Respiratory research, 10, 96-96 (2009-10-20)
The recognition of microbial molecular patterns via toll-like receptors (TLRs) is critical for mucosal defenses. Using well-differentiated primary cultures of human airway epithelia, we investigated the effects of exposure of the cells to cytokines (TNF-alpha and IFN-gamma) and dexamethasone (dex)
Sufang Li et al.
Journal of molecular and cellular cardiology, 75, 49-57 (2014-07-08)
The activation of a hemostatic system plays a critical role in the incidence of acute coronary events. Hemostatic proteins may be regulated by microRNAs (miRNAs). Microparticles (MPs) are the major carrier of circulating miRNAs. The aim of this study was
Adam Cisterne et al.
PloS one, 9(7), e103383-e103383 (2014-07-26)
Resistance to apoptosis remains a significant problem in drug resistance and treatment failure in malignant disease. NO-aspirin is a novel drug that has efficacy against a number of solid tumours, and can inhibit Wnt signaling, and although we have shown
Rahima Zennadi
PloS one, 9(10), e110306-e110306 (2014-10-21)
In sickle cell disease, sickle erythrocyte (SSRBC) interacts with endothelial cells, leukocytes, and platelets, and activates coagulation and inflammation, promoting vessel obstruction, which leads to serious life-threatening complications, including acute painful crises and irreversible damage to multiple organs. The mitogen-activated
Robert J van Eijkeren et al.
Frontiers in endocrinology, 11, 479-479 (2020-08-28)
The complex direct and indirect interplay between adipocytes and various adipose tissue (AT)-resident immune cells plays an important role in maintaining local and whole-body insulin sensitivity. Adipocytes can directly interact with and activate AT-resident invariant natural killer T (iNKT) cells
Qiong Xue et al.
Science signaling, 8(381), ra59-ra59 (2015-06-18)
Macrophages not only produce multiple cytokines but also respond to multiple cytokines, which likely shapes the ultimate response of the population. To determine the role of paracrine signaling in shaping the profile of inflammatory cytokines secreted by macrophages in response
Kristia S Hamilton et al.
Science signaling, 7(329), ra55-ra55 (2014-06-12)
Signaling to the mechanistic target of rapamycin (mTOR) regulates diverse cellular processes, including protein translation, cellular proliferation, metabolism, and autophagy. Most models place Akt upstream of the mTOR complex, mTORC1; however, in T cells, Akt may not be necessary for
Nathaniel W Snyder et al.
Chemico-biological interactions, 234, 144-153 (2014-12-03)
Bioactive lipids govern cellular homeostasis and pathogenic inflammatory processes. Current dogma holds that bioactive lipids, such as prostaglandins and lipoxins, are inactivated by 15-hydroxyprostaglandin dehydrogenase (15PGDH). In contrast, the present results reveal that catabolic "inactivation" of hydroxylated polyunsaturated fatty acids
E-W Lee et al.
Cell death and differentiation, 22(9), 1463-1476 (2015-01-24)
Given their crucial role in apoptosis suppression, inhibitor of apoptosis proteins (IAPs) have recently become attractive targets for cancer therapy. Here, we report that cellular IAP2 (cIAP2) is specifically stabilized in several cancer cell lines, leading to resistance to Smac
Karine Enesa et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(5), 1869-1878 (2015-02-11)
A20 protects against pathologic vascular remodeling by inhibiting the inflammatory transcription factor NF-κB. A20's function has been attributed to ubiquitin editing of receptor-interacting protein 1 (RIP1) to influence activity/stability. The validity of this mechanism was tested using a murine model
Zhemin Shi et al.
The FEBS journal, 284(7), 1096-1109 (2017-03-16)
The aberrant accumulation of β-amyloid peptide (Aβ) in the brain is a key feature of Alzheimer's disease (AD), and enhanced cleavage of β-amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) has a major causative role in AD. Despite
Caroline S Bruikman et al.
Arteriosclerosis, thrombosis, and vascular biology, 40(2), 462-472 (2019-12-06)
Netrin-1 has been shown to play a role in the initiation of atherosclerosis in mice models. However, little is known about the role of Netrin-1 in humans. We set out to study whether Netrin-1 is associated with different stages of
Xinxing Zhu et al.
Atherosclerosis, 281, 38-46 (2019-01-19)
Endothelium inflammation, which can lead to endothelial activation and dysfunction, is widely accepted as the major event in multiple vascular disorders. The lncRNA HOXA-AS2 was previously reported to be involved in multiple inflammation-linked cancers. However, the role of HOXA-AS2 in
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