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L4777
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关键词:'L4777'
显示 1-30 共 155 条结果 关于 "L4777" 范围 论文
Rebecca E K MacPherson et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(8), R644-R650 (2013-02-15)
Evidence indicates that skeletal muscle lipid droplet-associated proteins (PLINs) regulate lipolysis through protein-protein interactions on the lipid droplet surface. In adipocytes, PLIN1 is thought to regulate lipolysis by directly interacting with comparative gene identification-58 (CGI-58), an activator of adipose triglyceride
Maxime Bessières et al.
Current protocols in nucleic acid chemistry, 59, 14-14 (2014-12-17)
The detailed synthetic protocol for the straightforward, efficient synthesis of various alkenyl acyclonucleosides, including challenging trisubstituted alkenyl acyclonucleoside phosphonates, is described. The key step of those syntheses is an olefin cross-metathesis reaction between two olefins selected based on their reactivity
Cécilia Eydoux et al.
Biochemistry, 47(36), 9553-9564 (2008-08-16)
Access to the active site of pancreatic lipase (PL) is controlled by a surface loop, the lid, which normally undergoes conformational changes only upon addition of lipids or amphiphiles. Structures of PL with their lids in the open and functional
Kristoffer T G Rigbolt et al.
Science signaling, 4(164), rs3-rs3 (2011-03-17)
To elucidate cellular events underlying the pluripotency of human embryonic stem cells (hESCs), we performed parallel quantitative proteomic and phosphoproteomic analyses of hESCs during differentiation initiated by a diacylglycerol analog or transfer to media that had not been conditioned by
Elena Smirnova et al.
EMBO reports, 7(1), 106-113 (2005-10-22)
Lipid droplets (LDs), also called adiposomes, are found in many eukaryotic cells, and are highly upregulated in lipid-storage cells, such as adipocytes. The mechanism by which adiposomes and their component neutral lipids are degraded is an important health issue with
Myung-ryul Lee et al.
Organic letters, 10(22), 5317-5319 (2008-10-30)
The reaction of chlorosulfonyl isocyanate (CSI) with alkenes provides beta-lactams in quantity, and the products have frequently been used for ring-opening polymerization to generate nylon-3 materials. Prior uses of this approach have focused almost entirely on beta-lactams with purely hydrocarbon
H van Tilbeurgh et al.
Nature, 362(6423), 814-820 (1993-04-29)
The three-dimensional structure of the lipase-procolipase complex, co-crystallized with mixed micelles of phosphatidylcholine and bile salt, has been determined at 3 A resolution by X-ray crystallography. The lid, a surface helix covering the catalytic triad of lipase, adopts a totally
First report of telaprevir-induced pancreatitis.
Carlos Ventura et al.
Digestive diseases and sciences, 58(3), 887-888 (2013-02-09)
Niels Grarup et al.
The Journal of clinical endocrinology and metabolism, 93(6), 2294-2299 (2008-03-28)
Hepatic lipase plays a pivotal role in the metabolism of high-density lipoprotein (HDL) and low-density lipoprotein by involvement in reverse cholesterol transport and the formation of atherogenic small dense low-density lipoprotein. The objective was to investigate the impact of variants
Luigi Notari et al.
The Journal of biological chemistry, 281(49), 38022-38037 (2006-10-13)
Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. We have previously provided biochemical evidence for high affinity PEDF-binding sites and proteins in plasma membranes of
Renaud Berlemont et al.
Revista Argentina de microbiologia, 45(1), 3-12 (2013-04-09)
in order to isolate novel organic solvent-tolerant (OST) lipases, a metagenomic library was built using DNA derived from a temperate forest soil sample. A two-step activity-based screening allowed the isolation of a lipolytic clone active in the presence of organic
Leah E Ross et al.
Biochimica et biophysica acta, 1831(6), 1052-1059 (2013-03-09)
The adsorption of colipase is essential for pancreatic triglyceride lipase activity and efficient dietary fat digestion. Yet, little is known about which specific amino acids in the hydrophobic surface of colipase influence adsorption. In this study, we systematically substituted alanine
Geoff P Lin-Cereghino et al.
Gene, 519(2), 311-317 (2013-03-05)
The methylotrophic yeast, Pichia pastoris, has been genetically engineered to produce many heterologous proteins for industrial and research purposes. In order to secrete proteins for easier purification from the extracellular medium, the coding sequence of recombinant proteins is initially fused
Euna Choi et al.
BMC research notes, 15(1), 370-370 (2022-12-13)
Staphylococcus epidermidis is a skin colonizer and a major cause of nosocomial infections that can lead to sepsis. It causes opportunistic infections by forming biofilms on medical devices, which are hard to control with conventional antibiotics. In an attempt to
Y Mechref et al.
Glycobiology, 9(3), 227-234 (1999-02-20)
The detailed structures of N- glycans derived from bile salt-stimulated lipase (BSSL) found in human milk were determined by combining exoglycosidase digestion with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The N- glycan structures were conclusively determined in terms of complexity
Roland Klingenberg et al.
The Journal of clinical investigation, 123(3), 1323-1334 (2013-02-22)
Atherosclerosis is a chronic inflammatory disease promoted by hyperlipidemia. Several studies support FOXP3-positive regulatory T cells (Tregs) as inhibitors of atherosclerosis; however, the mechanism underlying this protection remains elusive. To define the role of FOXP3-expressing Tregs in atherosclerosis, we used
Yuan Xie et al.
The Journal of biological chemistry, 289(11), 7994-8006 (2014-01-23)
Enzyme stability is an important issue for protein engineers. Understanding how rigidity in the active site affects protein kinetic stability will provide new insight into enzyme stabilization. In this study, we demonstrated enhanced kinetic stability of Candida antarctica lipase B
M Jaye et al.
Nature genetics, 21(4), 424-428 (1999-04-07)
High-density lipoprotein (HDL) cholesterol levels are inversely associated with risk of atherosclerotic cardiovascular disease. At least 50% of the variation in HDL cholesterol levels is genetically determined, but the genes responsible for variation in HDL levels have not been fully
G Civallero et al.
Gene, 539(1), 154-156 (2014-02-11)
Lysosomal acid lipase (LAL) deficiency produces two well defined inborn disorders, Wolman disease (WD) and cholesteryl ester storage disease (CESD). WD is a severe, early-onset condition involving massive storage of triglycerides and cholesteryl esters in the liver, with death usually
Krystyna Tatarkiewicz et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(7), R490-R498 (2014-01-31)
Glucagon-like peptide 1 receptors (GLP-1R) are expressed in multiple tissues and activation results in metabolic benefits including enhanced insulin secretion, slowed gastric emptying, suppressed food intake, and improved hepatic steatosis. Limited and inconclusive knowledge exists regarding whether the effects of
Alfredo Morabia et al.
Human molecular genetics, 12(21), 2733-2743 (2003-09-11)
This study explored the genetic basis of the combination of extreme blood levels of HDL-C and LDL-C, a well-studied endophenotype for CVD, which has several attractive features as a target for genetic analysis: (1) the trait is moderately heritable; (2)
Chemical and enzymatic interesterification of tristearin/triolein-rich blends: Chemical composition, solid fat content and thermal properties
Ahmadi L, et al.
European Journal of Lipid Science and Technology, 1014-1024 (2008)
Leslie A Lange et al.
American journal of human genetics, 94(2), 233-245 (2014-02-11)
Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants.
O Tiebel et al.
Human mutation, 12(3), 216-216 (2000-02-05)
Human hepatic lipase (hHL) plays an important role in hydrolysis of triglycerides from plasma lipoproteins. The enzyme also hydrolyzes HDL2 lipids resulting in smaller HDL particles with a lower cholesterol content and properties similar to HDL3. hHL is localized in
Ji Young Kim et al.
American journal of physiology. Endocrinology and metabolism, 291(1), E115-E127 (2006-05-18)
The minimal adipose phenotype of hormone-sensitive lipase (HSL)-null mice suggested that other hormonally responsive lipase(s) were present in adipocytes. Recent studies have characterized a new adipose tissue triglyceride lipase, ATGL/PNPLA2/destnutrin/iPLA2zeta/TTS2.2 (ATGL). We had previously cloned a novel adipose-enriched transcript by
Lipase: An Industrial Enzyme Through Metagenomics (2018)
How high-density lipoprotein fuels the failing heart.
Nina Schlueter et al.
Hypertension (Dallas, Tex. : 1979), 61(5), 955-957 (2013-03-06)
Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation.
Nathalie Griffon et al.
The Journal of biological chemistry, 284(35), 23322-23330 (2009-07-02)
Endothelial lipase (EL) is a member of a subfamily of lipases that act on triglycerides and phospholipids in plasma lipoproteins, which also includes lipoprotein lipase and hepatic lipase. EL has a tropism for high density lipoprotein, and its level of
M W Bodmer et al.
Biochimica et biophysica acta, 909(3), 237-244 (1987-08-25)
The molecular cloning of a cDNA coding for human gastric lipase and its expression in yeast is described. A lipase present in human gastric aspirates was purified and its N-terminal amino-acid sequence was determined. This was found to be homologous
Timothy M O'Shea et al.
Advanced healthcare materials, 4(12), 1802-1812 (2015-06-20)
Hydrogels with covalently incorporated trehalose are synthesized using thiol-ene Michael addition. Trehalose hydrogels afford prolonged stabilization and -controlled release of model enzymes in vitro and in vivo as well as preservation of protein stability under heat and -lyophilization stressors. Strong
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