l4777

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Skeletal muscle PLIN proteins, ATGL and CGI-58, interactions at rest and following stimulated contraction.

Rebecca E K MacPherson et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 304(8), R644-R650 (2013-02-15)

Evidence indicates that skeletal muscle lipid droplet-associated proteins (PLINs) regulate lipolysis through protein-protein interactions on the lipid droplet surface. In adipocytes, PLIN1 is thought to regulate lipolysis by directly interacting with comparative gene identification-58 (CGI-58), an activator of adipose triglyceride

Olefin cross-metathesis for the synthesis of alkenyl acyclonucleoside phosphonates.

Maxime Bessières et al.

Current protocols in nucleic acid chemistry, 59, 14-14 (2014-12-17)

The detailed synthetic protocol for the straightforward, efficient synthesis of various alkenyl acyclonucleosides, including challenging trisubstituted alkenyl acyclonucleoside phosphonates, is described. The key step of those syntheses is an olefin cross-metathesis reaction between two olefins selected based on their reactivity

Chemical and enzymatic interesterification of tristearin/triolein-rich blends: Chemical composition, solid fat content and thermal properties

Ahmadi L, et al.

European Journal of Lipid Science and Technology, 1014-1024 (2008)

Long-term metabolic benefits of exenatide in mice are mediated solely via the known glucagon-like peptide 1 receptor.

Krystyna Tatarkiewicz et al.

American journal of physiology. Regulatory, integrative and comparative physiology, 306(7), R490-R498 (2014-01-31)

Glucagon-like peptide 1 receptors (GLP-1R) are expressed in multiple tissues and activation results in metabolic benefits including enhanced insulin secretion, slowed gastric emptying, suppressed food intake, and improved hepatic steatosis. Limited and inconclusive knowledge exists regarding whether the effects of

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.

Leslie A Lange et al.

American journal of human genetics, 94(2), 233-245 (2014-02-11)

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants.

The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects.

Niels Grarup et al.

The Journal of clinical endocrinology and metabolism, 93(6), 2294-2299 (2008-03-28)

Hepatic lipase plays a pivotal role in the metabolism of high-density lipoprotein (HDL) and low-density lipoprotein by involvement in reverse cholesterol transport and the formation of atherogenic small dense low-density lipoprotein. The objective was to investigate the impact of variants

Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor.

Luigi Notari et al.

The Journal of biological chemistry, 281(49), 38022-38037 (2006-10-13)

Pigment epithelium-derived factor (PEDF) is an extracellular multifunctional protein belonging to the serpin superfamily with demonstrable neurotrophic, gliastatic, neuronotrophic, antiangiogenic, and antitumorigenic properties. We have previously provided biochemical evidence for high affinity PEDF-binding sites and proteins in plasma membranes of

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Daniela S Gerhard et al.

Genome research, 14(10B), 2121-2127 (2004-10-19)

The National Institutes of Health's Mammalian Gene Collection (MGC) project was designed to generate and sequence a publicly accessible cDNA resource containing a complete open reading frame (ORF) for every human and mouse gene. The project initially used a random

Molecular cloning of a human gastric lipase and expression of the enzyme in yeast.

M W Bodmer et al.

Biochimica et biophysica acta, 909(3), 237-244 (1987-08-25)

The molecular cloning of a cDNA coding for human gastric lipase and its expression in yeast is described. A lipase present in human gastric aspirates was purified and its N-terminal amino-acid sequence was determined. This was found to be homologous

Facilitating chemical and biochemical experiments with electronic microcontrollers and single-board computers.

Gurpur Rakesh D Prabhu et al.

Nature protocols, 15(3), 925-990 (2020-01-31)

Since the advent of modern science, researchers have had to rely on their technical skills or the support of specialized workshops to construct analytical instruments. The notion of the 'fourth industrial revolution' promotes construction of customized systems by individuals using

Cloning of a unique lipase from endothelial cells extends the lipase gene family.

K Hirata et al.

The Journal of biological chemistry, 274(20), 14170-14175 (1999-05-13)

A new lipoprotein lipase-like gene has been cloned from endothelial cells through a subtraction methodology aimed at characterizing genes that are expressed with in vitro differentiation of this cell type. The conceptual endothelial cell-derived lipase protein contains 500 amino acids

Preparation of magnetic Fe3O4@SiO2 nanoparticles for immobilization of lipase.

Wei Liu et al.

Journal of nanoscience and nanotechnology, 14(4), 3068-3072 (2014-04-17)

Magnetic Fe3O4 nanoparticles were prepared with coprecipitatation method and covered with SiO2 to form the core-shell Fe3O4@SiO2 nanoparticles. Then the nanoparticles were modified with glutaradehyde for functionalization of the surface to aldehyde groups. The transmission electron microscopy confirmed the core-shell

Isolation and characterization of the human hepatic lipase gene.

D Ameis et al.

The Journal of biological chemistry, 265(12), 6552-6555 (1990-04-25)

Overlapping bacterial phage and cosmid genomic clones were isolated spanning an area of approximately 60 kilobases that contains the human hepatic lipase (HL) gene. It is composed of 9 exons spanning approximately 35 kilobases of DNA. The entire coding regions

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans.

A Kotronen et al.

Diabetologia, 52(6), 1056-1060 (2009-02-19)

It has recently been suggested that the rs738409 G allele in PNPLA3, which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try

Screening of solvents for favoring hydrolytic activity of Candida antarctica Lipase B.

Bartłomiej Zieniuk et al.

Bioprocess and biosystems engineering, 43(4), 605-613 (2019-11-18)

Lipases are a group of enzymes of considerable significance in organic synthesis, among which Candida antarctica lipase B (CALB) is one of the most widely studied enzymes. The activity of the biocatalyst has been intensively characterized in many organic media

Isolation and cDNA sequence of human postheparin plasma hepatic triglyceride lipase.

G A Martin et al.

The Journal of biological chemistry, 263(22), 10907-10914 (1988-08-05)

Hepatic triglyceride lipase (H-TGL) was isolated from human postheparin plasma by column chromatography on heparin-Sepharose and phenyl-Sepharose and immunoaffinity chromatography with monoclonal antibodies. The purified enzyme had an apparent molecular weight of 65,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis and

The DNA sequence of human chromosome 22.

I Dunham et al.

Nature, 402(6761), 489-495 (1999-12-11)

Knowledge of the complete genomic DNA sequence of an organism allows a systematic approach to defining its genetic components. The genomic sequence provides access to the complete structures of all genes, including those without known function, their control elements, and

Contribution of novel ATGL missense mutations to the clinical phenotype of NLSD-M: a strikingly low amount of lipase activity may preserve cardiac function.

Daniela Tavian et al.

Human molecular genetics, 21(24), 5318-5328 (2012-09-20)

The lack of adipose triglyceride lipase (ATGL), a patatin-like phospholipase domain-containing enzyme that hydrolyzes fatty acids from triacylglycerol (TAG) stored in multiple tissues, causes the autosomal recessive disorder neutral lipid storage disease with myopathy (NLSD-M). In two families of Lebanese

Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas.

M B Mazzucco et al.

The Journal of endocrinology, 217(3), 303-315 (2013-03-14)

Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. The primary aim of the study was to examine the effect of a saturated fat-rich diet (FD) on

Human liver arylacetamide deacetylase. Molecular cloning of a novel esterase involved in the metabolic activation of arylamine carcinogens with high sequence similarity to hormone-sensitive lipase.

M R Probst et al.

The Journal of biological chemistry, 269(34), 21650-21656 (1994-08-26)

Microsomal arylacetamide deacetylase (DAC) competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens in many species and tissues. Activity determination and immunoblot analysis of DAC in human

Structure of the human hepatic triglyceride lipase gene.

S J Cai et al.

Biochemistry, 28(23), 8966-8971 (1989-11-14)

The structure of the human hepatic triglyceride lipase gene was determined from multiple cosmid clones. All the exons, exon-intron junctions, and 845 bp of the 5' and 254 bp of the 3' flanking DNA were sequenced. Comparison of the exon

Lipase member H is a novel secreted protein selectively upregulated in human lung adenocarcinomas and bronchioloalveolar carcinomas.

Yasuhiro Seki et al.

Biochemical and biophysical research communications, 443(4), 1141-1147 (2014-01-02)

Lung cancer is one of the most frequent causes of cancer-related death worldwide. However, molecular markers for lung cancer have not been well established. To identify novel genes related to lung cancer development, we surveyed publicly available DNA microarray data

Properties and purification of adipose tissue lipase.

W S LYNN et al.

The Journal of biological chemistry, 235, 1912-1916 (1960-07-01)

Human milk bile-salt stimulated lipase. Sequence similarity with rat lysophospholipase and homology with the active site region of cholinesterases.

D L Christie et al.

FEBS letters, 278(2), 190-194 (1991-01-28)

To determine the active site residue, human milk bile-salt stimulated lipase (BSSL) was labelled with [3H]diisopropyl fluorophosphate (DFP). Partial sequence analysis of cyanogen bromide fragments (a total of 146 residues from 6 peptides) revealed 84% sequence identity with a putative

Biocatalyzed Synthesis of Flavor Esters and Polyesters: A Design of Experiments (DoE) Approach.

Filippo Fabbri et al.

International journal of molecular sciences, 22(16) (2021-08-28)

In the present work, different hydrolases were adsorbed onto polypropylene beads to investigate their activity both in short-esters and polyesters synthesis. The software MODDE® Pro 13 (Sartorius) was used to develop a full-factorial design of experiments (DoE) to analyse the

Adiponutrin: A new gene regulated by energy balance in human adipose tissue.

Yong-Ming Liu et al.

The Journal of clinical endocrinology and metabolism, 89(6), 2684-2689 (2004-06-08)

Adiponutrin is a newly identified nonsecreted adipocyte protein regulated by changes in energy balance in rodents. We documented the influence of energy balance modification on adiponutrin gene expression in humans. We investigated the mRNA expression in sc adipose tissue of

Role of SN1 lipases on plasma lipids in metabolic syndrome and obesity.

Verónica Miksztowicz et al.

Arteriosclerosis, thrombosis, and vascular biology, 34(3), 669-675 (2014-01-25)

To assess the phospholipase activity of endothelial (EL) and hepatic lipase (HL) in postheparin plasma of subjects with metabolic syndrome (MS)/obesity and their relationship with atherogenic and antiatherogenic lipoproteins. Additionally, to evaluate lipoprotein lipase (LPL) and HL activity as triglyceride

Tissue expression pattern and polymorphism of G0S2 gene in porcine.

Yanzhi Jiang et al.

Gene, 539(1), 173-179 (2014-02-04)

Adipose triglyceride lipase (ATGL), catalyzing the initial step of hydrolysis of triacylglycerol (TAG) in adipocytes, has been known to be inhibited by G0/G1 switch protein 2 (G0S2). In this study, we determined tissue expression pattern and polymorphism of G0S2 gene

Identification, cloning, expression, and purification of three novel human calcium-independent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities.

Christopher M Jenkins et al.

The Journal of biological chemistry, 279(47), 48968-48975 (2004-09-15)

Genetic knockout of hormone-sensitive lipase in mice has implicated the presence of other intracellular triacylglycerol (TAG) lipases mediating TAG hydrolysis in adipocytes. Despite intense interest in these TAG lipases, their molecular identities thus far are largely unknown. Sequence data base

Asymmetric Synthesis of Substituted Thiolanes through Domino Thia-Michael-Henry Dynamic Covalent Systemic Resolution using Lipase Catalysis.

Yan Zhang et al.

Advanced synthesis & catalysis, 356(5), 987-992 (2014-03-24)

Dynamic systems based on consecutive thia-Michael and Henry reactions were generated and transformed using lipase-catalyzed asymmetric transformation. Substituted thiolane structures with three contiguous stereocenters were resolved in the process in high yields and high enantiomeric excesses.

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