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显示 61-90 共 155 条结果 关于 "l4777" 范围 论文
John E Collins et al.
Genome biology, 5(10), R84-R84 (2004-10-06)
We have developed a systematic approach to generating cDNA clones containing full-length open reading frames (ORFs), exploiting knowledge of gene structure from genomic sequence. Each ORF was amplified by PCR from a pool of primary cDNAs, cloned and confirmed by
Chemical and enzymatic interesterification of tristearin/triolein-rich blends: Chemical composition, solid fat content and thermal properties
Ahmadi L, et al.
European Journal of Lipid Science and Technology, 1014-1024 (2008)
Identification of the active form of endothelial lipase, a homodimer in a head-to-tail conformation.
Nathalie Griffon et al.
The Journal of biological chemistry, 284(35), 23322-23330 (2009-07-02)
Endothelial lipase (EL) is a member of a subfamily of lipases that act on triglycerides and phospholipids in plasma lipoproteins, which also includes lipoprotein lipase and hepatic lipase. EL has a tropism for high density lipoprotein, and its level of
G Civallero et al.
Gene, 539(1), 154-156 (2014-02-11)
Lysosomal acid lipase (LAL) deficiency produces two well defined inborn disorders, Wolman disease (WD) and cholesteryl ester storage disease (CESD). WD is a severe, early-onset condition involving massive storage of triglycerides and cholesteryl esters in the liver, with death usually
Alfredo Morabia et al.
Human molecular genetics, 12(21), 2733-2743 (2003-09-11)
This study explored the genetic basis of the combination of extreme blood levels of HDL-C and LDL-C, a well-studied endophenotype for CVD, which has several attractive features as a target for genetic analysis: (1) the trait is moderately heritable; (2)
Kristoffer T G Rigbolt et al.
Science signaling, 4(164), rs3-rs3 (2011-03-17)
To elucidate cellular events underlying the pluripotency of human embryonic stem cells (hESCs), we performed parallel quantitative proteomic and phosphoproteomic analyses of hESCs during differentiation initiated by a diacylglycerol analog or transfer to media that had not been conditioned by
Elena Smirnova et al.
EMBO reports, 7(1), 106-113 (2005-10-22)
Lipid droplets (LDs), also called adiposomes, are found in many eukaryotic cells, and are highly upregulated in lipid-storage cells, such as adipocytes. The mechanism by which adiposomes and their component neutral lipids are degraded is an important health issue with
Structure and organization of the human carboxyl ester lipase locus.
K Madeyski et al.
Mammalian genome : official journal of the International Mammalian Genome Society, 9(4), 334-338 (1998-04-08)
Yuan Xie et al.
The Journal of biological chemistry, 289(11), 7994-8006 (2014-01-23)
Enzyme stability is an important issue for protein engineers. Understanding how rigidity in the active site affects protein kinetic stability will provide new insight into enzyme stabilization. In this study, we demonstrated enhanced kinetic stability of Candida antarctica lipase B
M Jaye et al.
Nature genetics, 21(4), 424-428 (1999-04-07)
High-density lipoprotein (HDL) cholesterol levels are inversely associated with risk of atherosclerotic cardiovascular disease. At least 50% of the variation in HDL cholesterol levels is genetically determined, but the genes responsible for variation in HDL levels have not been fully
Y Mechref et al.
Glycobiology, 9(3), 227-234 (1999-02-20)
The detailed structures of N- glycans derived from bile salt-stimulated lipase (BSSL) found in human milk were determined by combining exoglycosidase digestion with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The N- glycan structures were conclusively determined in terms of complexity
Euna Choi et al.
BMC research notes, 15(1), 370-370 (2022-12-13)
Staphylococcus epidermidis is a skin colonizer and a major cause of nosocomial infections that can lead to sepsis. It causes opportunistic infections by forming biofilms on medical devices, which are hard to control with conventional antibiotics. In an attempt to
First report of telaprevir-induced pancreatitis.
Carlos Ventura et al.
Digestive diseases and sciences, 58(3), 887-888 (2013-02-09)
Myung-ryul Lee et al.
Organic letters, 10(22), 5317-5319 (2008-10-30)
The reaction of chlorosulfonyl isocyanate (CSI) with alkenes provides beta-lactams in quantity, and the products have frequently been used for ring-opening polymerization to generate nylon-3 materials. Prior uses of this approach have focused almost entirely on beta-lactams with purely hydrocarbon
H van Tilbeurgh et al.
Nature, 362(6423), 814-820 (1993-04-29)
The three-dimensional structure of the lipase-procolipase complex, co-crystallized with mixed micelles of phosphatidylcholine and bile salt, has been determined at 3 A resolution by X-ray crystallography. The lid, a surface helix covering the catalytic triad of lipase, adopts a totally
Leah E Ross et al.
Biochimica et biophysica acta, 1831(6), 1052-1059 (2013-03-09)
The adsorption of colipase is essential for pancreatic triglyceride lipase activity and efficient dietary fat digestion. Yet, little is known about which specific amino acids in the hydrophobic surface of colipase influence adsorption. In this study, we systematically substituted alanine
F Carrière et al.
Protein engineering, 7(4), 563-569 (1994-04-01)
From primary structure comparison, the pancreatic lipase family is now divided into three subgroups: classical pancreatic lipases, pancreatic lipase-related proteins 1 (RPI) and pancreatic lipase-related proteins 2 (RP2). Among the RP2 subfamily, the guinea-pig and coypu enzymes share kinetic properties
J Hall et al.
The Journal of small animal practice, 54(5), 275-279 (2013-02-13)
Mushroom toxicosis is rarely diagnosed in dogs and is poorly reported in the veterinary literature. This report suggests that mushroom toxicosis is a potentially under-diagnosed condition in first opinion practice in the UK. Nine dogs with clinical signs consistent with
Dominique Langin et al.
Diabetes, 54(11), 3190-3197 (2005-10-27)
The mobilization of fat stored in adipose tissue is mediated by hormone-sensitive lipase (HSL) and the recently characterized adipose triglyceride lipase (ATGL), yet their relative importance in lipolysis is unknown. We show that a novel potent inhibitor of HSL does
Toshio Ota et al.
Nature genetics, 36(1), 40-45 (2004-01-01)
As a base for human transcriptome and functional genomics, we created the "full-length long Japan" (FLJ) collection of sequenced human cDNAs. We determined the entire sequence of 21,243 selected clones and found that 14,490 cDNAs (10,897 clusters) were unique to
Cristina Carrasco et al.
Cell biochemistry and function, 31(7), 585-590 (2014-04-30)
The purpose of our study was to evaluate the protective effect of melatonin in a rat model of caerulein-induced acute pancreatitis. For the induction of experimental acute pancreatitis, four subcutaneous injections of caerulein (20 mgkg–1 body weight) were given to
Hilary F Clark et al.
Genome research, 13(10), 2265-2270 (2003-09-17)
A large-scale effort, termed the Secreted Protein Discovery Initiative (SPDI), was undertaken to identify novel secreted and transmembrane proteins. In the first of several approaches, a biological signal sequence trap in yeast cells was utilized to identify cDNA clones encoding
Helge Raeder et al.
Nature genetics, 38(1), 54-62 (2005-12-22)
Dysfunction of the exocrine pancreas is observed in diabetes, but links between concurrent exocrine and endocrine pancreatic disease and contributing genetic factors are poorly characterized. We studied two families with diabetes and exocrine pancreatic dysfunction by genetic, physiological and in
Osvaldo Manuel Tiscornia et al.
Acta gastroenterologica Latinoamericana, 43(4), 294-300 (2014-02-13)
The present tests were undertaken in order to analyze in male Wistar rats the changes in the exocrine and endocrine pancreas and on the interactions that normally evolve in the insulo-pancreon-axis. To evaluate this by a single i.p. Boots secretin
Takanori Matsui et al.
Biochemical and biophysical research communications, 443(3), 847-851 (2013-12-18)
Pigment epithelium-derived factor (PEDF) has anti-inflammatory and anti-thrombogenic properties both in cell culture and animal models. Although adipose triglyceride lipase (ATGL) and laminin receptor (LR) are two putative receptors for PEDF, which receptor mainly mediates the beneficial effects of PEDF
M R Probst et al.
Biochemical and biophysical research communications, 177(1), 453-459 (1991-05-31)
Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens, best described as a carboxylesterase/amidase type of reaction. A 7-fold variation in the Vmax of 2-acetylaminofluorene deacetylation in 24 human livers was observed.
Stephen G Young et al.
Genes & development, 27(5), 459-484 (2013-03-12)
All organisms use fatty acids (FAs) for energy substrates and as precursors for membrane and signaling lipids. The most efficient way to transport and store FAs is in the form of triglycerides (TGs); however, TGs are not capable of traversing
Alessandro Pellis et al.
Nature communications, 10(1), 1762-1762 (2019-04-18)
Following concerns over increasing global plastic pollution, interest in the production and characterization of bio-based and biodegradable alternatives is rising. In the present work, the synthesis of a series of fully bio-based alternatives based on 2,4-, 2,5-, and 2,6-pyridinedicarboxylic acid-derived
Stefano Romeo et al.
Nature genetics, 40(12), 1461-1465 (2008-09-30)
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem of unknown etiology that varies in prevalence among ancestry groups. To identify genetic variants contributing to differences in hepatic fat content, we carried out a genome-wide association scan of nonsynonymous
Tao Liu et al.
Journal of proteome research, 4(6), 2070-2080 (2005-12-13)
The enormous complexity, wide dynamic range of relative protein abundances of interest (over 10 orders of magnitude), and tremendous heterogeneity (due to post-translational modifications, such as glycosylation) of the human blood plasma proteome severely challenge the capabilities of existing analytical
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