CN
Search Within
L8021
应用筛选条件
关键词:'L8021'
显示 1-30 共 282 条结果 关于 "L8021" 范围 论文
Julie Ry Gustafsson et al.
Journal of neuroscience methods, 274, 116-124 (2016-11-05)
Efficient and specific knockdown of proteins in post-mitotic cells such as differentiated neurons can be difficult to achieve. Further, special care must be taken to maintain the health of neurons in vitro. We wanted to achieve knockdown in primary cerebellar
Yong H Park et al.
Scientific reports, 9(1), 2594-2594 (2019-02-24)
Elevated intraocular pressure (IOP) is the major risk factor for glaucoma, a sight threatening disease of retinal ganglion cells (RGCs) and their axons. Despite the central importance of IOP, details of the impact of IOP elevation on RGC gene expression
Prithi Raguraman et al.
International journal of molecular sciences, 21(7) (2020-04-05)
Alpha-l-Locked nucleic acid (α-l-LNA) is a stereoisomeric analogue of locked nucleic acid (LNA), which possesses excellent biophysical properties and also exhibits high target binding affinity to complementary oligonucleotide sequences and resistance to nuclease degradations. Therefore, α-l-LNA nucleotides could be utilised
Jeffery D Haines et al.
Multiple sclerosis (Houndmills, Basingstoke, England), 21(13), 1655-1669 (2015-05-08)
Cerebrospinal fluid (CSF) is in contact with brain parenchyma and ventricles, and its composition might influence the cellular physiology of oligodendrocyte progenitor cells (OPCs) thereby contributing to multiple sclerosis (MS) disease pathogenesis. To identify the transcriptional changes that distinguish the
Bo Xue et al.
Experimental eye research, 153, 42-50 (2016-11-05)
Müller cell reactivation (gliosis) is an early response in glaucomatous retina. Previous studies have demonstrated that activation of P2X
Robert S Phillips et al.
Archives of biochemistry and biophysics, 634, 83-87 (2017-10-13)
STM2360 is a gene located in a small operon of undetermined function in Salmonella enterica serovar Typhimurium LT2. The amino acid sequence of STM2360 shows significant similarity (∼30% identity) to diaminopimelate decarboxylase (DapDC), a Fold III pyridoxal-5'-phosphate (PLP) dependent enzyme
Norio Tanabe et al.
Frontiers in pharmacology, 9, 446-446 (2018-06-06)
After spinal cord injury (SCI), reconstruction of neuronal tracts is very difficult because an inhibitory scar is formed at the lesion site, in which several axonal growth inhibitors, such as chondroitin sulfate proteoglycans (CSPG), accumulate. We previously found that matrine
Lauren V C Miller et al.
Acta neuropathologica communications, 9(1), 41-41 (2021-03-14)
A fundamental property of infectious agents is their particulate nature: infectivity arises from independently-acting particles rather than as a result of collective action. Assemblies of the protein tau can exhibit seeding behaviour, potentially underlying the apparent spread of tau aggregation
Faping Shen et al.
Brain research, 1704, 174-186 (2018-10-23)
Neural stem cells (NSCs) give rise to the central nervous system (CNS) and persist in certain areas of adult brains for replenishing damaged differentiated cells. The loss of the balance between NSC self-renewal and differentiation could lead to tumor formation
Efraín E Rivera-Serrano et al.
Virology, 502, 133-143 (2017-01-04)
Viral myocarditis is common and can progress to cardiac failure. Cardiac cell pro-inflammatory responses are critical for viral clearance, however sustained inflammatory responses contribute to cardiac damage. The transcription factor NF-κB regulates expression of many pro-inflammatory cytokines, but basal and
Thomas Christoph et al.
Biochemical and biophysical research communications, 500(2), 456-461 (2018-04-17)
N-ethyl-N-nitrosourea (ENU) random mutagenesis was used to generate a mouse model for the analysis of the transient receptor potential vanilloid 1 (TRPV1) cation channel. A transversion from T→A in exon 4 led to a Leu206Stop mutation generating a loss-of-function mutant.
Carlos G Vanoye et al.
The Journal of biological chemistry, 294(32), 12054-12065 (2019-06-20)
Charcot-Marie-Tooth (CMT) disease is a peripheral neuropathy associated with gene duplication and point mutations in the peripheral myelin protein 22 (PMP22) gene. However, the role of PMP22 in Schwann cell physiology and the mechanisms by which PMP22 mutations cause CMT
Thuy Thu Bui et al.
The Journal of general virology, 99(8), 1044-1057 (2018-06-20)
Dengue virus (DENV) replication between mosquito and human hosts is hypothesized to be associated with viral determinants that interact in a differential manner between hosts. However, the understanding of inter-host viral determinants that drive DENV replication and growth between hosts
Sergio Lainez et al.
Biochemical pharmacology, 150, 120-130 (2018-01-30)
Transient outward potassium current (Ito) contributes to early repolarization of many mammalian cardiac action potentials, including human, whilst the rapid delayed rectifier K+ current (IKr) contributes to later repolarization. Fast Ito channels can be produced from the Shal family KCNDE
Walter Huynh et al.
The Journal of cell biology, 216(10), 3051-3060 (2017-09-09)
Bicaudal D2 (BICD2) joins dynein with dynactin into a ternary complex (termed DDB) capable of processive movement. Point mutations in the BICD2 gene have been identified in patients with a dominant form of spinal muscular atrophy, but how these mutations
Susanne Meier et al.
Nature communications, 10(1), 4121-4121 (2019-09-13)
The functionality of most secreted proteins depends on their assembly into a defined quaternary structure. Despite this, it remains unclear how cells discriminate unassembled proteins en route to the native state from misfolded ones that need to be degraded. Here
Tomoko Abe et al.
The Journal of general and applied microbiology, 65(1), 1-10 (2018-06-15)
The adenylation domain of nonribosomal peptide synthetase (NRPS) is responsible for its selective substrate recognition and activation of the substrate (yielding an acyl-O-AMP intermediate) on ATP consumption. DhbF is an NRPS involved in bacillibactin synthesis and consists of multiple domains
Jordan Follett et al.
Neuroscience letters, 706, 114-122 (2019-05-15)
DNAJC13 (RME-8) is a core co-chaperone that facilitates membrane recycling and cargo sorting of endocytosed proteins. DNAJ/Hsp40 (heat shock protein 40) proteins are highly conserved throughout evolution and mediate the folding of nascent proteins, and the unfolding, refolding or degradation
Jiaojie Li et al.
Cells, 8(12) (2019-11-28)
Amyotrophic lateral sclerosis (ALS) caused by mutation of superoxide dismutase 1 (SOD1), affects various cellular processes and results in the death of motor neurons with fatal defects. Currently, several neurological disorders associated with DNA damage are known to directly induce
Wei Zhu et al.
The Journal of nutritional biochemistry, 48, 62-73 (2017-08-05)
The present study aimed to explore the underlying mechanisms of epicatechin-3-gallate-(4β→8, 2β→O→7)-epicatechin-3-gallate (A-type ECG dimer) and epigallocatechin-3-gallate-(4β→8, 2β→O→7)-epigallocatechin-3-gallate (A-type EGCG dimer) involved in their strong inhibitory effects on 3T3-L1 preadipocytes differentiation. In the synthetic "lipid raft-like" liposome, A-type ECG and
Haijun Bao et al.
Neuroscience letters, 634, 7-12 (2016-10-26)
Poloxamer 188 (P188) has been reported to reseal plasma membranes and attenuate TBI-induced neuronal death by suppressing apoptosis. Recent studies also confirm increased autophagy after traumatic brain injury (TBI). The present study aimed to investigate the effects of plasmalemmal resealing
Shivani Sachdev et al.
PeerJ, 7, e7733-e7733 (2019-10-04)
Synthetic cannabinoids are a commonly used class of recreational drugs that can have significant adverse effects. There have been sporadic reports of co-consumption of illicit drugs with rodenticides such as warfarin and brodifacoum (BFC) over the past 20 years but
Yong Hee Kim et al.
Journal of neuroscience methods, 202(1), 38-44 (2011-09-13)
We have prepared the poly-d-lysine (PDL) bound surfaces for neuron cell culture by covalent binding between the poly-d-Lysine and substrates and investigated neuronal cell adhesion properties and cell growth morphology. The number of neuronal cell and the number of neurite
Ying Yang et al.
Neurochemistry international, 94, 90-97 (2016-02-28)
White matter lesions (WML) are thought to contribute to vascular cognitive impairment in elderly patients. Growing evidence show that failure of myelin formation arising from the disruption of oligodendrocyte progenitor cell (OPC) differentiation is a cause of chronic vascular white
David M Irvin et al.
Brain pathology (Zurich, Switzerland), 27(1), 36-50 (2016-01-15)
The influence of cellular origin on glioma pathogenesis remains elusive. We previously showed that mutations inactivating Rb and Pten and activating Kras transform astrocytes and induce tumorigenesis throughout the adult mouse brain. However, it remained unclear whether astrocyte subpopulations were
S Lule et al.
Journal of autoimmunity, 84, 87-96 (2017-08-29)
Autoimmune and dysimmune inflammatory mechanisms on a genetically susceptible background are implicated in the etiology of Behçet's Disease (BD). Heat-shock protein-65 (HSP-65) derived from Streptococcus sanguinis was proposed as a triggering factor based on its homology with human HSP-60. However
Li Ou-Yang et al.
Acta pharmacologica Sinica, 39(1), 24-34 (2017-09-22)
Glial scar formation resulted from excessive astrogliosis limits axonal regeneration and impairs recovery of function, thus an intervention to ameliorate excessive astrogliosis is crucial for the recovery of neurological function after cerebral ischemia. In this study we investigated the effects
Allison Doyle Brackley et al.
Scientific reports, 7(1), 1842-1842 (2017-05-14)
Mechanical pain serves as a base clinical symptom for many of the world's most debilitating syndromes. Ion channels expressed by peripheral sensory neurons largely contribute to mechanical hypersensitivity. Transient Receptor Potential A 1 (TRPA1) is a ligand-gated ion channel that
Joel Frandsen et al.
ACS chemical neuroscience, 11(3), 356-366 (2020-01-08)
The glyoxalase pathway (GP) is an antioxidant defense system that detoxifies metabolic byproduct methylglyoxal (MG). Through sequential reactions, reduced glutathione (GSH), glyoxalase I (glo-1), and glyoxalase II (glo-2) convert MG into d-lactate. Spontaneous reactions involving MG alter the structure and
Minjuan Wang et al.
International journal of molecular sciences, 21(19) (2020-09-30)
Because of the importance of the HNK-1 carbohydrate for preferential motor reinnervation after injury of the femoral nerve in mammals, we screened NIH Clinical Collection 1 and 2 Libraries and a Natural Product library comprising small organic compounds for identification
1/10