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Barbara Stachowiak
Polish journal of microbiology, 62(1), 67-72 (2013-07-09)
Astaxanthin is a xanthophill pigment with commercial application in the aquaculture, pharmaceutical, food and cosmetic industries. The red yeast Xanthophyllomyces dendrorhous is one of the most promising microorganisms for its industrial production. However, astaxanthin content in wild yeast strains is
Supender Kaur et al.
Cell reports, 31(7), 107662-107662 (2020-05-21)
Increasing evidence suggests that deficient immune modulation and microbial infections underline neurodegeneration, but the mechanisms remain obscure. Here, we show that the G-protein-coupled receptor (GPCR) SRBC-48, which belongs to the class BC serpentine receptors, has a protective role in Caenorhabditis
Thanh Theresa Dinh et al.
Methods in molecular biology (Clifton, N.J.), 1110, 127-156 (2014-01-08)
The flower is a hallmark feature that has contributed to the evolutionary success of land plants. Diverse mutagenic agents have been employed as a tool to genetically perturb flower development and identify genes involved in floral patterning and morphogenesis. Since
Xiaoyue Wang et al.
Plant physiology, 179(1), 300-316 (2018-11-14)
The inhibition of primary root (PR) growth is a major developmental response of Arabidopsis (Arabidopsis thaliana) to phosphate (Pi) deficiency. Previous studies have independently uncovered key roles of the LOW PHOSPHATE RESPONSE1 (LPR1) ferroxidase, the tonoplast-localized ALUMINUM SENSITIVE3 (ALS3)/SENSITIVE TO
Carol Beevers et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 165-171 (2015-07-28)
As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM)-initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined sodium arsenite, thioacetamide, and diethanolamine. Using the JaCVAM approved study protocol version
Zhenyan Yan et al.
Plant physiology, 150(2), 710-721 (2009-04-28)
GLYCOGEN SYNTHASE KINASE3 (GSK3) is a highly conserved serine/threonine kinase involved in a variety of developmental signaling processes. The Arabidopsis (Arabidopsis thaliana) genome encodes 10 GSK3-like kinases that are clustered into four groups. Forward genetic screens have so far uncovered
Pristionchus pacificus protocols.
Andre Pires-daSilva
WormBook : the online review of C. elegans biology, 1-20 (2013-03-19)
Nidhi Rawat et al.
BMC plant biology, 12, 205-205 (2012-11-09)
Triticum monococcum L., an A genome diploid einkorn wheat, was the first domesticated crop. As a diploid, it is attractive genetic model for the study of gene structure and function of wheat-specific traits. Diploid wheat is currently not amenable to
Martina Galdíková et al.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes, 50(10), 698-707 (2015-08-15)
The potential genotoxic effect of thiacloprid formulation on bovine peripheral lymphocytes was evaluated using the comet assay and the cytogenetic endpoints: chromosome aberrations (CAs), sister chromatid exchanges (SCEs) and micronuclei (MNi). Whole blood cultures were treated with the insecticide at
Christina M Dittrich et al.
PloS one, 7(2), e24555-e24555 (2012-03-03)
The small nematode Caenorhabditis elegans displays a spectrum of DNA damage responses similar to humans. In order to identify new DNA damage response genes, we isolated in a forward genetic screen 14 new mutations conferring hypersensitivity to ionizing radiation. We
Kade M Power et al.
PLoS genetics, 16(10), e1009052-e1009052 (2020-10-17)
Ciliary microtubules are subject to post-translational modifications that act as a "Tubulin Code" to regulate motor traffic, binding proteins and stability. In humans, loss of CCP1, a cytosolic carboxypeptidase and tubulin deglutamylating enzyme, causes infantile-onset neurodegeneration. In C. elegans, mutations
Laura Vicedo Jacociunas et al.
Journal of medicinal food, 15(10), 873-878 (2012-08-16)
Cynara scolymus L. (Asteraceae), popularly known as artichoke, has been widely used in herbal medicine for the treatment of hepatic diseases. The genotoxicity of C. scolymus L. leaf extract (LE) and the ability to modulate the genetic toxicity of the
Kim L Hoang et al.
Evolution letters, 5(2), 118-129 (2021-04-20)
Protective symbionts can allow hosts to occupy otherwise uninhabitable niches. Despite the importance of symbionts in host evolution, we know little about how these associations arise. Encountering a microbe that can improve host fitness in a stressful environment may favor
Elmar Gocke et al.
Toxicology letters, 190(3), 254-265 (2009-10-28)
In order to assess the risk of patients being exposed to an anti-AIDS medication contaminated with EMS we have performed in depth genotoxicity, general toxicity and DMPK investigations. The results of these studies are reported in the accompanying papers of
Hoi Yee Keung et al.
Applied and environmental microbiology, 83(7) (2017-01-25)
Bifidobacteria exert beneficial effects on hosts and are extensively used as probiotics. However, due to the genetic inaccessibility of these bacteria, little is known about their mechanisms of carbohydrate utilization and regulation. Bifidobacterium breve strain JCM1192 can grow on water-insoluble
Krešimir Šola et al.
The Plant cell, 31(4), 809-831 (2019-03-11)
Cell-to-cell adhesion is essential for establishment of multicellularity. In plants, such adhesion is mediated through a middle lamella composed primarily of pectic polysaccharides. The molecular interactions that influence cell-to-cell adhesion are not fully understood. We have used Arabidopsis (Arabidopsis thaliana)
Pinar Erkekoglu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 72, 98-110 (2014-07-12)
Most common alkylanilines in the environment are 2,6-dimethylaniline (2,6-DMA), 3,5-dimethylaniline (3,5-DMA), and 3-ethylaniline (3-EA). 3,5-Dimethylaminophenol (3,5-DMAP), a metabolite of 3,5-DMA, is of particular interest, as it is potentially genotoxic. Supplementation with organic or inorganic forms of selenium (Se) may reduce
Genotoxicity Effect of Ethyl Methanesulfonate on Root Tip Cells of Chilli (Capsicum annuum L.)
Devi AS and Mullainathan L
World Journal of Agricultural Sciences, 7(4), 368-374 (2011)
Navot Galpaz et al.
Archives of biochemistry and biophysics, 539(2), 117-125 (2013-08-27)
In order to broaden the available genetic variation of melon, we developed an ethyl methanesulfonate mutation library in an orange-flesh 'Charentais' type melon line that accumulates β-carotene. One mutagenized M2 family segregated for a novel recessive trait, a yellow-orange fruit
Albor Dobón et al.
PloS one, 8(1), e55115-e55115 (2013-02-06)
Resistance to biotrophic pathogens is largely dependent on the hormone salicylic acid (SA) while jasmonic acid (JA) regulates resistance against necrotrophs. JA negatively regulates SA and is, in itself, negatively regulated by SA. A key component of the JA signal
Behzad Foroutan et al.
Journal of pharmacological and toxicological methods, 55(1), 58-64 (2006-04-21)
Resistance to an anthracycline-based regimen, such as CHOP, constitutes a problem for curing non-Hodgkin's lymphoma (NHL) patients. Chemoresistance in the clinic manifests itself as a lack of response to treatment or regrowth of a tumour after an initial response. In
Leon F Stankowski et al.
Mutagenesis, 30(3), 335-342 (2015-05-03)
As part of the international Pig-a validation trials, we examined the induction of Pig-a mutant reticulocytes and red blood cells (RET(CD59-) and RBC(CD59-), respectively) in peripheral blood of male Sprague Dawley(®) rats treated with urethane (25, 100 and 250mg/kg/day) or
Novel wine yeast with ARO4 and TYR1 mutations that overproduce `floral?aroma compounds 2-phenylethanol and 2-phenylethyl acetate
Cordente AG, et al.
Applied Microbiology and Biotechnology, 1-12 (2018)
Sandhya Sukumaran et al.
Ecotoxicology and environmental safety, 91, 110-116 (2013-02-19)
The impact of chronic genotoxicity to natural populations is always questioned due to their reproductive surplus. We used a comet assay to quantify primary DNA damage after exposure to a reference mutagen ethyl methane sulfonate in two species of crustacean
Gaynor A Smith et al.
Neuron, 103(1), 52-65 (2019-05-19)
Mitochondria are essential in long axons to provide metabolic support and sustain neuron integrity. A healthy mitochondrial pool is maintained by biogenesis, transport, mitophagy, fission, and fusion, but how these events are regulated in axons is not well defined. Here
He Zhao et al.
Nature communications, 11(1), 518-518 (2020-01-26)
Ethylene plays essential roles during adaptive responses to water-saturating environments in rice, but knowledge of its signaling mechanism remains limited. Here, through an analysis of a rice ethylene-response mutant mhz1, we show that MHZ1 positively modulates root ethylene responses. MHZ1
Philip E Boulais et al.
Biochemical pharmacology, 85(4), 541-550 (2012-12-12)
The chemokine SDF-1 (CXCL12) selectively binds to CXCR4, a member of the G protein-coupled receptor (GPCR) superfamily. In this study, we used the substituted-cysteine accessibility method (SCAM) to identify specific residues of the fourth transmembrane domain (TM4) that contribute to
Stephanie E Jones et al.
eLife, 6 (2017-01-04)
It has long been thought that the life cycle of Streptomyces bacteria encompasses three developmental stages: vegetative hyphae, aerial hyphae and spores. Here, we show interactions between Streptomyces and fungi trigger a previously unobserved mode of Streptomyces development. We term
A R Kraynak et al.
Mutation research. Genetic toxicology and environmental mutagenesis, 786-788, 77-86 (2015-07-28)
As part of the Japanese Center for the Validation of Alternative Methods (JaCVAM) initiative international validation study of the in vivo rat alkaline comet assay (comet assay), we examined the ability of the assay to determine the genotoxicity of 2-acetylaminofluorene
Sandhya Sukumaran et al.
Mutation research, 757(1), 8-14 (2013-07-23)
There is considerable evidence that genetic damage in organisms occurs in the environment as a result of exposure to genotoxins and ionising radiation, but we have limited understanding of the extent to which this results in adverse consequences at a
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