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显示 1-30 共 1183 条结果 关于 "M3262" 范围 论文
Mantosh Kumar et al.
Neuroscience letters, 709, 134343-134343 (2019-07-08)
Calcium influx through N-methyl-D-aspartate receptors (NMDAR) and voltage-gated calcium channels (VGCC) play major roles in postsynaptic signaling mechanisms. NMDAR subunit GluN2B is phosphorylated at Ser1303. Phosphorylation at this site is a prominent event in cell culture systems as well as
Jiaheng Xie et al.
Investigative ophthalmology & visual science, 62(3), 29-29 (2021-03-23)
The human PDZK1 gene is located in a genomic susceptibility region for neurodevelopmental disorders. A genome-wide association study identified links between PDZK1 polymorphisms and altered visual contrast sensitivity, an endophenotype for schizophrenia and autism spectrum disorder. The PDZK1 protein is
Guan Hock Khoo et al.
Molecular neurobiology, 56(9), 6436-6450 (2019-03-04)
Long-term depression (LTD) of synaptic efficacy is widely regarded as a cellular basis of learning and memory. The magnitude of hippocampal CA1 LTD induced by low-frequency stimulation (LFS) declines with age, but the mechanisms involved remain poorly understood. Perineuronal nets
Rodrigo de Andrade Rufino et al.
Brain structure & function, 224(4), 1537-1551 (2019-03-09)
A few studies have evaluated the behavioral roles of the periaqueductal gray (PAG) in animals facing ethologically relevant threats. Exposure to a live cat induces striking activation in the rostrodorsal and caudal ventral PAG. In the present investigation, we first
Annie Delaunois et al.
Journal of pharmacological and toxicological methods, 104, 106874-106874 (2020-05-25)
Several compounds from a neuroscience project induced convulsions in animals, at low exposure levels via a hypothetical off-target mechanism. A set of in vitro and in vivo experiments were conducted in order to 1) identify the mechanism behind convulsions; 2)
Hanna Ahlgren et al.
The Journal of biological chemistry, 289(14), 9970-9982 (2014-02-12)
The focal swellings of dendrites ("dendritic beading") are an early morphological hallmark of neuronal injury and dendrotoxicity. They are associated with a variety of pathological conditions, including brain ischemia, and cause an acute disruption of synaptic transmission and neuronal network
Gábor Remzső et al.
Scientific reports, 9(1), 18900-18900 (2019-12-13)
Cortical spreading depolarization (SD) involves activation of NMDA receptors and elicit neurovascular unit dysfunction. NMDA cannot trigger SD in newborns, thus its effect on neurovascular function is not confounded by other aspects of SD. The present study investigated if NMDA
Fatemeh Babaei et al.
Journal of food science, 83(9), 2280-2287 (2018-08-14)
Quercetin (3,3',4',5,7-pentahydroxyflavone) is found in vegetables and fruits. It is one of the major flavonoids that is part of human diets. Quercetin has several pharmacological effects in the nervous system as a neuroprotective agent. In this review, we summarize the
Adriana B Ghislandi et al.
Journal of molecular neuroscience : MN, 70(4), 590-599 (2019-12-24)
The severity score of quinolinic acid (QA)-induced seizures was investigated after N-methyl-D-aspartate (NMDA) preconditioning associated with adenosine receptors. Also, the levels of adenosine A1 and A2A receptors and subunits of NMDA receptors in the hippocampi of mice were determined to
Jonathan Aow et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), 14711-14716 (2015-11-11)
The NMDA receptor (NMDAR) is known to transmit important information by conducting calcium ions. However, some recent studies suggest that activation of NMDARs can trigger synaptic plasticity in the absence of ion flow. Does ligand binding transmit information to signaling
Hiroaki Okuda et al.
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 22(5), 153-158 (2002-11-28)
Glutamate, the endogenous excitatory amino acid, is involved in the pathophysiology of the phenomenon of excitotoxic neuronal damages. Among glutamate receptors, NMDA receptors play a major role in these processes. In cultured cerebellar granule neurons, paradoxically, treatment with a subtoxic
Shun-Ming Ting et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 40(3), 513-527 (2019-03-21)
Excitotoxicity and microglia/macrophage over-activation are the important pathogenic steps in brain damage caused by ischemic stroke. Recent studies from our group suggest that the neurons in ischemic penumbra generate an anti-inflammatory cytokine, interleukin-4 (IL-4). This neuron-produced IL-4 could subsequently convert
Elizabeth G Mietlicki-Baase et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(20), 6985-6992 (2014-05-16)
Glucagon-like peptide-1 receptor (GLP-1R) activation in the nucleus accumbens (NAc) core is pharmacologically and physiologically relevant for regulating palatable food intake. Here, we assess whether GLP-1R signaling in the NAc core of rats modulates GABAergic medium spiny neurons (MSNs) through
Jacob E Montgomery et al.
Physiological reports, 9(6), e14774-e14774 (2021-03-27)
N-methyl-d-aspartate (NMDA) application has conventionally been used to activate spinal networks to induce locomotion in spinalized animals. We recently described an alternative approach in which application of continuous blue light activates channelrhodopsin-2 in vesicular glutamate transporter 2a (vglut2a)-expressing spinal neurons
Shihao Lin et al.
Journal of neurophysiology, 121(4), 1352-1367 (2019-01-10)
Spinal cord injury leads to a devastating loss of motor function and yet is accompanied by a paradoxical emergence of muscle spasms, which often involve complex muscle activation patterns across multiple joints, reciprocal muscle timing, and rhythmic clonus. We investigated
Ryan P D Alexander et al.
The Journal of physiology, 599(2), 647-665 (2020-11-05)
We show that NMDA receptors (NMDARs) elicit a long-term increase in the firing rates of inhibitory stellate cells of the cerebellum NMDARs induce intrinsic plasticity through a Ca2+ - and CaMKII-dependent pathway that drives shifts in the activation and inactivation
Carmen Carbone et al.
Frontiers in cellular neuroscience, 11, 187-187 (2017-07-14)
Differential vulnerability between Substantia Nigra pars compacta (SNpc) and Ventral Tegmental Area (VTA) dopaminergic (DAergic) neurons is a hallmark of Parkinson's disease (PD). Understanding the molecular bases of this key histopathological aspect would foster the development of much-needed disease-modifying therapies.
Adel Kashefi et al.
Brain research bulletin, 166, 118-127 (2020-12-03)
Methylphenidate (MPH) is a mild CNS stimulant that has been used in hyperactive children, and patients with neurodegenerative and major depressive disorders. Exposure to MPH-associated cues enhances craving and arousal in drug users. On the other hand, cannabidiol (CBD) has
Chih-Ming Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(4), E619-E628 (2017-01-11)
Stability of neuronal connectivity is critical for brain functions, and morphological perturbations are associated with neurodegenerative disorders. However, how neuronal morphology is maintained in the adult brain remains poorly understood. Here, we identify Wnt5a, a member of the Wnt family
Shijie Zheng et al.
Investigative ophthalmology & visual science, 56(2), 1168-1180 (2015-01-24)
To investigate whether activation of liver X receptors (LXRs) protects N-methyl-D-aspartic (NMDA)-induced retinal neurotoxicity in mice and to explore the underlying mechanism. Inner retinal damage was induced by intravitreal injection of NMDA. A synthetic LXR ligand TO901317 (TO90, 50 mg/kg/d)
Xinhuai Liu et al.
eLife, 10 (2021-01-20)
The necessity and functional significance of neurotransmitter co-transmission remains unclear. The glutamatergic 'KNDy' neurons co-express kisspeptin, neurokinin B (NKB), and dynorphin and exhibit a highly stereotyped synchronized behavior that reads out to the gonadotropin-releasing hormone (GnRH) neuron dendrons to drive
Ujval Anilkumar et al.
Cell death & disease, 11(5), 321-321 (2020-05-07)
Mitochondria play a crucial role in neuronal survival through efficient energy metabolism. In pathological conditions, mitochondrial stress leads to neuronal death, which is regulated by the anti-apoptotic BCL-2 family of proteins. MCL-1 is an anti-apoptotic BCL-2 protein localized to mitochondria
Paraskevi Krania et al.
Journal of neurochemistry, 145(3), 217-231 (2017-12-06)
Interaction between mGluR5 and NMDA receptors (NMDAR) is vital for synaptic plasticity and cognition. We recently demonstrated that stimulation of mGluR5 enhances NMDAR responses in hippocampus by phosphorylating NR2B(Tyr1472) subunit, and this reaction was enabled by adenosine A2A receptors (A2A
Yuto Aoki et al.
Biological & pharmaceutical bulletin, 38(2), 321-324 (2015-03-10)
Inhibitors of the mammalian target of rapamycin (mTOR) have been shown to protect against neuronal injury, but the mechanisms underlying this effect are not fully understood. The present study aimed to examine the effects of rapamycin, an inhibitor of the
Ayodeji O Egunlusi et al.
ChemMedChem, 10(7), 1259-1266 (2015-05-28)
Neurodegenerative disorders are debilitating conditions characterised by progressive dysfunction and death of neuronal cells. Amidst the proposed mechanisms of neurodegeneration, the effects of excitotoxicity via N-methyl-D-aspartate (NMDA) receptor stimulation and activation of voltage-gated calcium channels (VGCC) on neuronal cells are
Natalia A Shevtsova et al.
Frontiers in neural circuits, 14, 614615-614615 (2021-01-12)
The mechanisms involved in generation of rhythmic locomotor activity in the mammalian spinal cord remain poorly understood. These mechanisms supposedly rely on both intrinsic properties of constituting neurons and interactions between them. A subset of Shox2 neurons was suggested to
Misawa Niki Ishii et al.
Toxicology, 389, 130-138 (2017-07-02)
Accurate risk assessment for drug-induced seizure is expected to be performed before entering clinical studies because of its severity and fatal damage to drug development. Induced pluripotent stem cell (iPSC) technology has allowed the use of human neurons and glial
Komal Thapa et al.
Life sciences, 267, 118975-118975 (2021-01-03)
Poly (ADP-ribose) polymerase- (PARP)-1 is predominantly triggered by DNA damage. Overexpression of PARP-1 is known for its association with the pathogenesis of several CNS disorders, such as Stroke, Parkinson's disease (PD), Alzheimer's disease (AD), Huntington (HD) and Amyotrophic lateral sclerosis
Gonzalo S Tejeda et al.
EMBO molecular medicine, 11(7), e9950-e9950 (2019-07-06)
Neuroprotective strategies aimed to pharmacologically treat stroke, a prominent cause of death, disability, and dementia, have remained elusive. A promising approach is restriction of excitotoxic neuronal death in the infarct penumbra through enhancement of survival pathways initiated by brain-derived neurotrophic
Ali Siahposht-Khachaki et al.
Neuroscience letters, 662, 147-151 (2017-10-22)
Neural circuitry comprising the ventral tegmental area, nucleus accumbens (NAc), prefrontal cortex (PFC) and hippocampus (HIP) has a main role in reward phenomena. Previous behavioral studies indicated that intracerebroventricular administration of AP5 (NMDA glutamate receptor antagonist) and CNQX (AMPA/kainate glutamate
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