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关键词:'MAB367'
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Linda Katona et al.
Brain structure & function, 225(2), 705-734 (2020-02-06)
In the hippocampal CA1 area, the GABAergic trilaminar cells have their axon distributed locally in three layers and also innervate the subiculum. Trilaminar cells have a high level of somato-dendritic muscarinic M2 acetylcholine receptor, lack somatostatin expression and their presynaptic
Grethe M Olsen et al.
The Journal of comparative neurology, 524(18), 3774-3809 (2016-04-30)
This study refines the characterization of the rat parietal cortical domain in terms of cyto- and chemoarchitecture as well as thalamic connectivity. We recognize three subdivisions of the posterior parietal cortex (PPC), which are architectonically distinct from the neighboring somatosensory
Species-specific in vivo engraftment of the human BL melanoma cell line results in an invasive dedifferentiated phenotype not present in xenografts.
Cedervall, J; Jamil, S; Prasmickaite, L; Cheng, Y; Eskandarpour, M; Hansson et al.
Cancer Research null
A M Harrington et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 22(9), 999-1008 (2010-02-12)
Muscarinic acetylcholine receptors (MR) are involved in multiple intestinal reflexes. The cellular localization of subtypes of MRs within enteric circuits mediating muscle and mucosal reflexes remains to be demonstrated. This study aimed to localize the three functionally significant subtypes of
Shawn D Burton et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 37(5), 1117-1138 (2016-12-23)
In the main olfactory bulb (MOB), the first station of sensory processing in the olfactory system, GABAergic interneuron signaling shapes principal neuron activity to regulate olfaction. However, a lack of known selective markers for MOB interneurons has strongly impeded cell-type-selective
Minas Salib et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(23), 4527-4549 (2019-03-31)
The medial septum implements cortical theta oscillations, a 5-12 Hz rhythm associated with locomotion and paradoxical sleep reflecting synchronization of neuronal assemblies such as place cell sequence coding. Highly rhythmic burst-firing parvalbumin-positive GABAergic medial septal neurons are strongly coupled to
Tristan Geiller et al.
Neuron, 108(5), 968-983 (2020-10-07)
Cortical computations are critically reliant on their local circuit, GABAergic cells. In the hippocampus, a large body of work has identified an unprecedented diversity of GABAergic interneurons with pronounced anatomical, molecular, and physiological differences. Yet little is known about the
Michael Winder et al.
Basic & clinical pharmacology & toxicology, 121(4), 257-265 (2017-04-25)
In the urinary bladder, the main source of NO seems to be the urothelium and the underlying suburothelium. In this study, we aimed to characterize how receptors in the human urothelium regulate the production and release of NO. For this
Léa Milan et al.
PloS one, 10(8), e0135525-e0135525 (2015-08-26)
Large cholinergic synaptic terminals known as C-boutons densely innervate the soma and proximal dendrites of motoneurons that are prone to neurodegeneration in amyotrophic lateral sclerosis (ALS). Studies using the Cu/Zn-superoxide dismutase (SOD1) mouse model of ALS have generated conflicting data
Michael S Sidorov et al.
Cell reports, 32(11), 108152-108152 (2020-09-17)
Mechanisms of experience-dependent plasticity have been well characterized in mouse primary visual cortex (V1), including a form of potentiation driven by repeated presentations of a familiar visual sequence ("sequence plasticity"). The prefrontal anterior cingulate cortex (ACC) responds to visual stimuli
Visuomotor interactions in the mouse forebrain mediated by extrastriate cortico-cortical pathways.
Hovde, et al.
Frontiers in Neuroanatomy, 17, 1188808-1188808 (2023)
S Iino et al.
Neuroscience, 138(2), 549-559 (2006-01-03)
In the enteric nervous system, acetylcholine is the most common neurotransmitter to induce gastrointestinal smooth muscle contractions. Cholinergic signaling is mediated by muscarinic acetylcholine receptors on the surface of smooth muscle cells. Five different muscarinic receptor subtypes (M(1)-M(5)) have been
Ana Fajardo-Serrano et al.
Neuroscience, 357, 349-362 (2017-06-21)
The basolateral amygdala receives a very dense cholinergic innervation from the basal forebrain that is important for memory consolidation. Although behavioral studies have shown that both M1 and M2 muscarinic receptors are critical for these mnemonic functions, there have been
Andrew M Meier et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(22), 4809-4825 (2021-04-15)
The postrhinal area (POR) is a known center for integrating spatial with nonspatial visual information and a possible hub for influencing landmark navigation by affective input from the amygdala. This may involve specific circuits within muscarinic acetylcholine receptor 2 (M2)-positive
Angelika Więckowska et al.
Journal of neurochemistry, 147(3), 361-379 (2018-08-14)
Complete thoracic spinal cord transection (SCT) impairs excitatory cholinergic inputs to ankle extensor (soleus; Sol) but not to flexor (tibialis anterior; TA) α-motoneurons (MNs) modifiable by locomotor training applied post-transection. The purpose of this study was to investigate whether Sol
Karoline Hovde et al.
The European journal of neuroscience, 49(10), 1313-1329 (2018-11-21)
The posterior parietal cortex (PPC) is a multifaceted region of cortex, contributing to several cognitive processes, including sensorimotor integration and spatial navigation. Although recent years have seen a considerable rise in the use of rodents, particularly mice, to investigate PPC
Maria Medalla et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(44), 15611-15625 (2012-11-02)
The anterior cingulate cortex (ACC) and dorsolateral prefrontal cortices (DLPFC) share robust excitatory connections. However, during rapid eye movement (REM) sleep, when cortical activity is dominated by acetylcholine, the ACC is activated but DLPFC is suppressed. Using pathway tracing and
Rinaldo D D'Souza et al.
Nature communications, 13(1), 503-503 (2022-01-28)
Neocortical computations underlying vision are performed by a distributed network of functionally specialized areas. Mouse visual cortex, a dense interareal network that exhibits hierarchical properties, comprises subnetworks interconnecting distinct processing streams. To determine the layout of the mouse visual hierarchy
Samir N P Kelada et al.
American journal of respiratory cell and molecular biology, 45(4), 817-824 (2011-03-08)
Asthma is etiologically and clinically heterogeneous, making the genomic basis of asthma difficult to identify. We exploited the strain-dependence of a murine model of allergic airway disease to identify different genomic responses in the lung. BALB/cJ and C57BL/6J mice were
Lisa Lambert et al.
Frontiers in cellular neuroscience, 12, 450-450 (2018-12-18)
Our aim was to examine the dynamics of the muscarinic m2 receptor (m2R), a G-protein coupled receptor (GPCR), after agonist activation in living hippocampal neurons, and especially clathrin dependency endocytosis. We have previously shown that the m2R undergoes agonist-induced internalization
Ludovic Tricoire et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(30), 10948-10970 (2011-07-29)
Although vastly outnumbered, inhibitory interneurons critically pace and synchronize excitatory principal cell populations to coordinate cortical information processing. Precision in this control relies upon a remarkable diversity of interneurons primarily determined during embryogenesis by genetic restriction of neuronal potential at
Bor-Shuen Wang et al.
Neuron, 109(3), 502-515 (2020-12-09)
In mammals with binocular vision, integration of the left and right visual scene relies on information in the center visual field, which are relayed from each retina in parallel and merge in the primary visual cortex (V1) through the convergence
Kristi A Kohlmeier et al.
Journal of neurophysiology, 108(10), 2751-2766 (2012-09-08)
Cholinergic neurons in the laterodorsal tegmental (LDT) and peduncolopontine tegmental (PPT) nuclei regulate reward, arousal, and sensory gating via major projections to midbrain dopamine regions, the thalamus, and pontine targets. Muscarinic acetylcholine receptors (mAChRs) on LDT neurons produce a membrane
Rinaldo David D'Souza et al.
eLife, 5 (2016-10-22)
Diverse features of sensory stimuli are selectively processed in distinct brain areas. The relative recruitment of inhibitory and excitatory neurons within an area controls the gain of neurons for appropriate stimulus coding. We examined how such a balance of inhibition
Răzvan Gămănuţ et al.
Neuron, 97(3), 698-715 (2018-02-09)
The inter-areal wiring pattern of the mouse cerebral cortex was analyzed in relation to a refined parcellation of cortical areas. Twenty-seven retrograde tracer injections were made in 19 areas of a 47-area parcellation of the mouse neocortex. Flat mounts of
Jurate Lasiene et al.
Acta neuropathologica communications, 4, 15-15 (2016-02-20)
Increasing evidence implicates the role of the cell types surrounding motor neurons, such as interneurons and glial cells, in non-cell autonomous neurodegeneration of amyotrophic lateral sclerosis (ALS). C-boutons, the large cholinergic synapses that innervate spinal α-motor neurons to control their
Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.
Takeuchi, T; Fujinami, K; Goto, H; Fujita, A; Taketo, MM; Manabe, T; Matsui, M; Hata, F
Journal of Neurophysiology null
Dexamethasone acts as a radiosensitizer in three astrocytoma cell lines via oxidative stress.
Ortega-Martinez, S
Redox Biology null
Kenneth D Harris et al.
PLoS biology, 16(6), e2006387-e2006387 (2018-06-19)
Understanding any brain circuit will require a categorization of its constituent neurons. In hippocampal area CA1, at least 23 classes of GABAergic neuron have been proposed to date. However, this list may be incomplete; additionally, it is unclear whether discrete
Alexandra Tsolias et al.
Frontiers in neural circuits, 15, 795325-795325 (2022-01-29)
Acetylcholine (ACh) can act on pre- and post-synaptic muscarinic receptors (mAChR) in the cortex to influence a myriad of cognitive processes. Two functionally-distinct regions of the prefrontal cortex-the lateral prefrontal cortex (LPFC) and the anterior cingulate cortex (ACC)-are differentially innervated
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