搜索范围
MRN70
应用筛选条件
关键词:'MRN70'
显示 1-18 共 18 条结果 关于 "MRN70" 范围 论文
Xihong Zhou et al.
Gut microbes, 14(1), 2091369-2091369 (2022-06-28)
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced
Shuangwei Li et al.
Genes & cancer, 1(4), 316-330 (2010-08-27)
The transcription factor ATF2 was previously shown to be an ATM substrate. Upon phosphorylation by ATM, ATF2 exhibits a transcription-independent function in the DNA damage response through localization to DNA repair foci and control of cell cycle arrest. To assess
Dan Dominissini et al.
Nature protocols, 8(1), 176-189 (2013-01-05)
N(6)-methyladenosine-sequencing (m(6)A-seq) is an immunocapturing approach for the unbiased transcriptome-wide localization of m(6)A in high resolution. To our knowledge, this is the first protocol to allow a global view of this ubiquitous RNA modification, and it is based on antibody-mediated
Adrenal gland-dependent augmentation of plasminogen activator inhibitor-1 expression in streptozotocin-induced diabetic mice.
Oishi K
Journal of Thrombosis and Haemostasis, 4(7), 1566-1574 (2006)
Enjie Li et al.
eLife, 11 (2022-05-04)
Methyltransferase-like 3 (METTL3) and N6-methyladenosine (m6A) are involved in many types of biological and pathological processes, including DNA repair. However, the function and mechanism of METTL3 in DNA repair and chemotherapeutic response remain largely unknown. In present study, we identified
K Oishi et al.
Journal of thrombosis and haemostasis : JTH, 4(7), 1566-1574 (2006-07-15)
Diabetes is associated with an excess risk of cardiac events, and one risk factor for infarction is an elevated level of plasminogen activator inhibitor-1 (PAI-1). To evaluate whether the glucocorticoid hormones are involved in the diabetes-induced PAI-1 production, we examined
The nuclear retention signal of HPV16 L2 protein is essential for incoming viral genome to transverse the trans-Golgi network.
DiGiuseppe S, Bienkowska-Haba M, Hilbig L, et al.
Virology, 458-459, 93-105 (2014)
Transcriptome-wide mapping of N(6)-methyladenosine by m(6)A-seq based on immunocapturing and massively parallel sequencing.
Dominissini D
Nature Protocols, 8(1), 176-189 (2013)
Mª Jesús Núñez-Iglesias et al.
International journal of molecular sciences, 22(13) (2021-07-21)
Prostate (PC) and breast cancer (BC) are heterogeneous hormonal cancers. Treatment resistance and adverse effects are the main limitations of conventional chemotherapy treatment. The use of sensitizing agents could improve the effectiveness of chemotherapeutic drugs as well as obviate these
Marimuthu Kumaravel et al.
Scientific reports, 10(1), 4501-4501 (2020-03-13)
Somatic embryos are comparable to their zygotic counterparts for morphological traits but are derived from somatic cells through various metabolic regulations, collectively referred as somatic embryogenesis (SE). It has been well exploited for germplasm conservation, genetic engineering, mutation breeding, for
Kaiju Sun et al.
Theranostics, 11(12), 5831-5846 (2021-04-27)
Purpose: The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenging. Fat mass and obesity associated protein (FTO), an mRNA N6-methyladenosine (m6A) demethylase, functions as an oncogene that promotes leukemic oncogene-mediated cell transformation and leukemogenesis. Here, we
Hong Ye et al.
Endocrine journal, 68(8), 981-992 (2021-05-07)
Honokiol plays an important role in anti-oxidation, but its role in diabetic vascular complications is unclear. In this study, the effects of honokiol in high glucose/high fat (HG/HF)-induced human umbilical vein endothelial cells (HUVECs) were explored. After pre-treatment with honokiol
Fei Yan et al.
Cell research, 28(11), 1062-1076 (2018-10-10)
N6-methyladenosine (m6A) on mRNAs is critical for various biological processes, yet whether m6A regulates drug resistance remains unknown. Here we show that developing resistant phenotypes during tyrosine kinase inhibitor (TKI) therapy depends on m6A reduction resulting from FTO overexpression in
Stephen DiGiuseppe et al.
Virology, 458-459, 93-105 (2014-06-15)
The Human papillomavirus (HPV) capsid is composed of the major and minor capsid proteins, L1 and L2, respectively. Infectious entry requires a complex series of conformational changes in both proteins that lead to uptake and allow uncoating to occur. During
Min Wang et al.
Molecular cancer, 19(1), 130-130 (2020-08-28)
Pancreatic cancer is one of the most lethal human cancers. N6-methyladenosine (m6A), a common eukaryotic mRNA modification, plays critical roles in both physiological and pathological processes. However, its role in pancreatic cancer remains elusive. LC/MS was used to profile m6A
Chenjing Zhang et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(1), 122-132 (2020-01-10)
N6-methyladenosine (m6A) modification in RNA has been implicated in diverse biological processes. However, very little is currently known about its role in nociceptive modulation. Here, we found that the level of spinal m6A modification was significantly increased in a mouse
Lintao Zhong et al.
Molecular therapy. Nucleic acids, 21, 394-411 (2020-07-11)
Identifying effective drugs to delay the progression of aortic aneurysms is a formidable challenge in vascular medicine. Methyltransferase-like 3 (METTL3) plays a key role in catalyzing the formation of N6-methyladenosine (m6A), but despite the functional importance of METTL3 and m6A
Miguel Angel Garcia-Campos et al.
Cell, 178(3), 731-747 (2019-07-02)
N6-methyladenosine (m6A) is the most abundant modification on mRNA and is implicated in critical roles in development, physiology, and disease. A major limitation has been the inability to quantify m6A stoichiometry and the lack of antibody-independent methodologies for interrogating m6A.
1/1