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关键词:'N149'
显示 1-30 共 113 条结果 关于 "N149" 范围 论文
R Grobe-Einsler
Clinical neuropharmacology, 16 Suppl 1, S39-S45 (1993-01-01)
This overview describes the result of the clinical development program in organic brain syndrome (impaired brain function in old age), where efficacy was proven in 11 double-blind, placebo-controlled studies. Another study within this development program showed nimodipine not only to
Nima Etminan et al.
Acta neurochirurgica. Supplement, 120, 281-286 (2014-11-05)
The effective reduction of delayed cerebral ischemia (DCI), a main contributor for poor outcome following aneurysmal subarachnoid hemorrhage (SAH), remains challenging. Previous clinical trials on systemic pharmaceutical treatment of SAH mostly failed to improve outcome, probably because of insensitive pharmaceutical
Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses
Daschil N and Humpel C
Brain Research, 1581, 1-11 (2014)
Camillo Sherif et al.
Acta neurochirurgica. Supplement, 120, 203-207 (2014-11-05)
Delayed vasospasm (VSP) following aneurysmal subarachnoid hemorrhage (aSAH) remains a major source of morbidity. Milrinone was recently suggested as an invasive VSP treatment option. It is a phosphodiesterase III inhibitor with vasodilating and additional positive inotrope and anti-inflammatory effects. In
I Ioannidis et al.
Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences, 18(3), 297-302 (2012-09-11)
Reversible cerebral vasoconstriction syndrome (RCVS) is characterized by acute severe headache with or without additional neurological symptoms and reversible cerebral vasoconstriction. Unruptured aneurysms have been reported in some cases with RCVS. We describe a severe case of a 50-year-old woman
Ling-Ling Shen et al.
Neural regeneration research, 10(6), 925-931 (2015-07-23)
Curcumin has been shown to significantly improve spatial memory impairment induced by HIV-1 gp120 V3 in rats, but the electrophysiological mechanism remains unknown. Using extracellular microelectrode recording techniques, this study confirmed that the gp120 V3 loop could suppress long-term potentiation
J Horn et al.
Stroke, 32(10), 2433-2438 (2001-10-06)
Based on the results of animal experiments, clinical trials were performed with nimodipine, which did not demonstrate a beneficial effect on outcome after stroke. The aim of this study was to determine whether the evidence from animal experiments with nimodipine
Ozgur Ismailoglu et al.
Turkish neurosurgery, 22(6), 740-746 (2012-12-05)
Secondary brain injury starts after the initial traumatic impact and marked by an increase in the intracellular calcium concentrations.This cascadeeventually results in membrane lipid peroxidation and neuronal cell death. We investigated the neuro-protective effects of nimodipine and melatonin in 38
Jianping Zhang et al.
Toxicology letters, 218(3), 273-280 (2013-02-23)
Exposure to lead (Pb) can induce kidney damage, which is related to induction of oxidative damage and disturbance of intracellular calcium homeostasis. Pb can readily permeate through dihydropyridine-sensitive L-type calcium channels and accumulate within cells. The objective of this study
Mohammad Hasan et al.
The Cochrane database of systematic reviews, 3(3), CD002750-CD002750 (2013-04-02)
This is an updated version of the original Cochrane review published in The Cochrane Library 2001, Issue 4.Nearly a third of people with epilepsy do not have their seizures controlled with current treatments. Continuous attempts have been made to find
Sufyan Ashhad et al.
Journal of neurophysiology, 113(7), 2002-2013 (2015-01-02)
The synaptic plasticity literature has focused on establishing necessity and sufficiency as two essential and distinct features in causally relating a signaling molecule to plasticity induction, an approach that has been surprisingly lacking in the intrinsic plasticity literature. In this
Nicole Schöbel et al.
Chemical senses, 39(6), 471-487 (2014-04-11)
Astringency is an everyday sensory experience best described as a dry mouthfeel typically elicited by phenol-rich alimentary products like tea and wine. The neural correlates and cellular mechanisms of astringency perception are still not well understood. We explored taste and
Daniel B L Teh et al.
Development, growth & differentiation, 56(8), 583-594 (2014-10-07)
In the adult hippocampus, new neurons are continuously generated and incorporated into the local circuitry in a manner dependent on the network activity. Depolarization evoked by neurotransmitters has been assumed to activate L-type Ca2+ channels (LTCC) which regulate the intracellular
Shohei Segawa et al.
Metallomics : integrated biometal science, 7(7), 1067-1077 (2015-04-30)
To elucidate the regulatory mechanism for extracellular zinc in the CNS, we examined the zinc uptake characteristics in mouse astrocytes and microglia. Zinc was taken up into the two cell types time-dependently, and the cell-to-medium concentration (C/M) ratio in the
Shiping Zou et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(32), 11384-11398 (2015-08-14)
Myelin pallor in HIV(+) individuals can occur very early during the disease process. While myelin damage might partly originate from HIV-induced vascular changes, the timing suggests that myelin and/or oligodendrocytes (OLs) may be directly affected. Histological (Golgi-Kopsch, electron microscopy) and
S E Johansson et al.
Acta physiologica (Oxford, England), 214(3), 376-389 (2015-05-06)
In this study, we aimed to investigate whether changes in cerebrovascular voltage-dependent calcium channels and non-selective cation channels contribute to the enhanced endothelin-1-mediated vasoconstriction in the delayed hypoperfusion phase after experimental transient forebrain ischaemia. Experimental forebrain ischaemia was induced in
Jia Zhu et al.
PloS one, 7(9), e46012-e46012 (2012-10-11)
Zinc distributes widely in the central nervous system, especially in the hippocampus, amygdala and cortex. The dynamic balance of zinc is critical for neuronal functions. Zinc modulates the activity of N-methyl-D-aspartate receptors (NMDARs) through the direct inhibition and various intracellular
Meghan MacKenzie et al.
The Canadian journal of hospital pharmacy, 67(5), 358-365 (2014-11-05)
Aneurysmal subarachnoid hemorrhage is a significant cause of death and disability. Nimodipine 60 mg administered enterally every 4 h improves neurologic outcomes in these patients. However, hypotension is an adverse effect of nimodipine and is believed to prompt clinicians to
W Mück et al.
Die Pharmazie, 49(2-3), 130-139 (1994-02-01)
The analytical test procedures currently established for the determination of the dihydropyridine calcium antagonist nimodipine in biological fluids are presented. Method of choice which has been dominantly used in pharmacokinetic investigations and drug interaction studies is gas chromatography with electron-capture
Tianzhen He et al.
Science advances, 6(40) (2020-10-02)
CD4+Foxp3+ regulatory T cells (Tregs) are pivotal for the inhibition of autoimmune inflammatory responses. One way to therapeutically harness the immunosuppressive actions of Tregs is to stimulate the proliferative expansion of TNFR2-expressing CD4+Foxp3+ Tregs via transmembrane TNF (tmTNF). Here, we
Potential interactions between nimodipine and adrenal hormones.
R L Isaacson et al.
Annals of the New York Academy of Sciences, 765, 134-142 (1995-09-15)
Sarah Y Branch et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(28), 9310-9318 (2014-07-11)
Substantia nigra dopamine neurons are involved in behavioral processes that include cognition, reward learning, and voluntary movement. Selective deterioration of these neurons is responsible for the motor deficits associated with Parkinson's disease (PD). Aging is the leading risk factor for
Shoko Horibe et al.
Neuroscience research, 87, 33-39 (2014-07-16)
Visual cortical neurons undergo depression and potentiation of their visual responses to stimulation of the deprived and non-deprived eyes, respectively, after monocular deprivation. This modification occurs predominantly during an early postnatal period in normal development, and this critical period is
Shaum S Sridharan et al.
The Laryngoscope, 125(1), 186-190 (2014-09-18)
To retrospectively determine optimal timing for initiation of nimodipine within a cohort of patients with acute vocal fold paralysis (VFP). Retrospective patient review. Subjects were divided into three groups: initiation within 15 days postinjury (n = 19), between 15 and
P Ortega et al.
Aquatic toxicology (Amsterdam, Netherlands), 157, 21-29 (2014-12-03)
Membrane pathway for intracellular cadmium (Cd(2+)) accumulation is not fully elucidated in many organisms and has not been studied in crab gill cells. To characterize membrane Cd(2+) transport of anterior and posterior gill cells of Ucides cordatus, a hypo-hyper-regulating crab
Ester Ponzetto et al.
Journal of neurosurgery, 119(5), 1125-1128 (2013-08-27)
The authors describe a rare case of central auditory dysfunction induced by cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH). A 55-year-old woman who was admitted after aneurysmal SAH developed cerebral vasospasm on Day 3 affecting mainly the right middle cerebral
Daniel Radzicki et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(24), 9920-9931 (2013-06-14)
Febrile seizures are associated with increased brain temperature and are often resistant to treatments with antiepileptic drugs, such as carbamazepine and phenytoin, which are sodium channel blockers. Although they are clearly correlated with the hyperthermic condition, the precise cellular mechanisms
Tian-Dong Leng et al.
CNS neuroscience & therapeutics, 21(1), 32-39 (2014-08-30)
Previous study demonstrated that overstimulation of TRPM7 substantially contributes to zinc-mediated neuronal toxicity. Inhibition of TRPM7 activity and TRPM7-mediated intracellular Zn(2+) accumulation may represent a promising strategy in the treatment of stroke. To investigate whether local anesthetics lidocaine could inhibit
Josue Haubrich et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(2), 315-326 (2014-07-17)
The capacity to adapt to new situations is one of the most important features of memory. When retrieved, memories may undergo a labile state that is sensitive to modification. This process, called reconsolidation, can lead to memory updating through the
Allan Kjeldsen Hansen et al.
Journal of neurophysiology, 112(3), 631-643 (2014-09-25)
Behavior-associated theta-frequency oscillation in the hippocampal network involves a patterned activation of place cells in the CA1, which can be accounted for by a somatic-dendritic interference model predicting the existence of an intrinsic dendritic oscillator. Here we describe an intrinsic
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