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Marc Galimand et al.
Antimicrobial agents and chemotherapy, 59(9), 5647-5653 (2015-07-08)
Corynebacterium striatum BM4687 was resistant to gentamicin and tobramycin but susceptible to kanamycin A and amikacin, a phenotype distinct among Gram-positive bacteria. Analysis of the entire genome of this strain did not detect any genes for known aminoglycoside resistance enzymes.
Xindong Teng et al.
Human vaccines & immunotherapeutics, 11(6), 1456-1464 (2015-04-24)
Different strategies have been proposed for the development of protein subunit vaccine candidates for tuberculosis (TB), which shows better safety than other types of candidates and the currently used Bacillus Calmette-Guérin (BCG) vaccine. In order to develop more effective protein
Masanori Mizutani et al.
Infection and immunity, 82(10), 4348-4357 (2014-08-06)
A multistage malaria vaccine targeting the pre-erythrocytic and sexual stages of Plasmodium could effectively protect individuals against infection from mosquito bites and provide transmission-blocking (TB) activity against the sexual stages of the parasite, respectively. This strategy could help prevent malaria
Sung-Jun Hong et al.
Journal of basic microbiology, 54(6), 500-508 (2014-01-21)
The present study demonstrates cloning, expression, and characterization of hyperthermostable L-asparaginase from Thermococcus kodakarensis KOD1 in Escherichia coli BLR(DE3). The recombinant 6× His-tagged protein L-asparaginase from T. kodakarensis (TkAsn), was purified to homogeneity by heat treatment followed by affinity chromatography
Jaime Tomé-Amat et al.
The FEBS journal, 282(11), 2131-2141 (2015-03-11)
Immunotoxins are chimeric proteins composed of an antibody domain that specifically directs the action of the toxic domain, resulting in the death of the targeted cells. Over recent years, immunotoxins have been widely studied and the number of different constructions
Jinyeong Kim et al.
Protein expression and purification, 116, 90-97 (2015-08-16)
A novel gene encoding a thermostable esterase (designated as Est-gela) was isolated from the moderate thermophile Bacillus gelatini KACC 12197. The open reading frame of this gene (1170 bp) encodes 389 amino acid residues, and the molecular weight of Est-gela
Oliver Einsle
Structure (London, England : 1993), 20(7), 1132-1134 (2012-07-10)
The process of dissimilatory metal reduction shapes our environment on a global scale by using minerals as terminal acceptors in a biological electron transport chain employed by bacteria under anaerobic conditions. In this issue of Structure, Edwards et al. present the
Kim Granholm et al.
Analytica chimica acta, 888, 36-43 (2015-09-01)
A new method to convert the potential of an ion-selective electrode to concentration or activity in potentiometric titration is proposed. The advantage of this method is that the electrode standard potential and the slope of the calibration curve do not
Nitrilotriacetic acid and its salts.
IARC monographs on the evaluation of carcinogenic risks to humans, 73, 385-399 (2000-05-11)
Yingshuang Wang et al.
The Journal of biological chemistry, 290(47), 28200-28213 (2015-10-08)
Retinoblastoma protein (RB) plays critical roles in tumor suppression and is degraded through the proteasomal pathway. However, E3 ubiquitin ligases responsible for proteasome-mediated degradation of RB are largely unknown. Here we characterize a novel RB E3 ubiquitin ligase (NRBE3) that
Joshua E Herskovitz et al.
Journal of agricultural and food chemistry, 68(7), 2164-2173 (2020-01-28)
Reactive extrusion of bio-derived active packaging offers a new approach to address converging concerns over environmental contamination and food waste. Herein, metal-chelating nitrilotriacetic acid (NTA) ligands were grafted onto poly(lactic acid) (PLA) by reactive extrusion to produce metal-chelating PLA (PLA-g-NTA).
Brian R Tuinema et al.
mBio, 5(6), e01886-e01886 (2014-11-27)
Neutrophils engulf and kill bacteria using oxidative and nonoxidative mechanisms. Despite robust antimicrobial activity, neutrophils are impaired in directing Salmonella clearance and harbor viable intracellular bacteria during early stages of infection that can subsequently escape to more-permissive cell types. The
Debadrita Mukherjee et al.
Nucleic acids research, 43(3), 1407-1417 (2015-01-22)
HlyU, a transcriptional regulator common in many Vibrio species, activates the hemolysin gene hlyA in Vibrio cholerae, the rtxA1 operon in Vibrio vulnificus and the genes of plp-vah1 and rtxACHBDE gene clusters in Vibrio anguillarum. The protein is also proposed
Dian-lei Guo et al.
Journal of virological methods, 222, 164-169 (2015-07-05)
An immunochromatographic strip (ICS) was developed for the detection of swine antibodies against glycoprotein E (gE) in Pseudorabies Virus (PRV). In this test, Staphylococcal Protein A (SPA) labeled with colloidal gold was dispensed on a conjugate pad as the detector.
Jürgen Knöll et al.
Journal of chromatography. A, 1270, 219-224 (2012-12-12)
An indirect method for the determination of ultra trace amounts of aminopolycarboxylic acids in surface water with a minimum of sample preparation was developed. It is based on the addition of a metal ion to the water sample in order
Oliver Scholz et al.
Nucleic acids research, 42(14), 9182-9194 (2014-07-24)
We introduce designed ankyrin repeat binding proteins (DARPins) as a novel class of highly specific and structure-selective DNA-binding proteins, which can be functionally expressed within all cells. Human telomere quadruplex was used as target to select specific binders with ribosome
Joseph Ashour et al.
Journal of virology, 89(5), 2792-2800 (2014-12-30)
Perturbation of protein-protein interactions relies mostly on genetic approaches or on chemical inhibition. Small RNA viruses, such as influenza A virus, do not easily lend themselves to the former approach, while chemical inhibition requires that the target protein be druggable.
R L Anderson et al.
Critical reviews in toxicology, 15(1), 1-102 (1985-01-01)
This article provides a review of available information on the chemistry, environmental toxicology, and mammalian toxicology of nitrilotriacetic acid (NTA). The ability of NTA to chelate metal ions such as Mg++ and Ca++ into water soluble complexes makes NTA useful
Sudeep Banjade et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(47), E6426-E6435 (2015-11-11)
The organization of membranes, the cytosol, and the nucleus of eukaryotic cells can be controlled through phase separation of lipids, proteins, and nucleic acids. Collective interactions of multivalent molecules mediated by modular binding domains can induce gelation and phase separation
Huamin Tang et al.
Journal of virology, 88(18), 10875-10882 (2014-07-11)
Recently, we identified a novel receptor, CD134, which interacts with the human herpesvirus 6B (HHV-6B) glycoprotein (g)H/gL/gQ1/gQ2 complex and plays a key role in the entry of HHV-6B into target cells. However, details of the interaction between the HHV-6B gH/gL/gQ1/gQ2
Tae-Hyoun Kim et al.
Immunobiology, 220(1), 26-31 (2014-12-03)
Heat shock protein 70 from Mycobacterium tuberculosis (Mtb Hsp70) has been known to modulate immune response including dendritic cell activation. Muramyl dipeptide (MDP) is an immunoreactive derivative of peptidoglycan from all Gram-negative and Gram-positive bacteria and recognized to be responsible
Yanbiao Zhou et al.
Planta, 241(3), 727-740 (2014-12-10)
Heterologous expression of a fungal NADP(H)-GDH gene ( MgGDH ) from Magnaporthe grisea can improve dehydration stress tolerance in rice by preventing toxic accumulation of ammonium. Glutamate dehydrogenase (GDH; EC 1.4.1.2 and EC 1.4.1.4) may act as a stress-responsive enzyme
H Edward Wong et al.
International journal of molecular sciences, 16(9), 22735-22753 (2015-09-25)
Techniques to incorporate non-natural amino acids (NNAAs) have enabled biosynthesis of proteins containing new building blocks with unique structures, chemistry, and reactivity that are not found in natural amino acids. It is crucial to understand how incorporation of NNAAs affects
Guan-Jun Yang et al.
Fish & shellfish immunology, 44(2), 603-610 (2015-04-07)
C-type lectin-like receptors (CLRs) are important pathogen pattern recognition molecules that recognize carbohydrate structures. However, the functions of these receptors in fish keep less known. In this study, we characterized a novel CLR from a teleost fish, Plecoglossus altivelis (ayu)
Andrew J Marshall et al.
Bioorganic & medicinal chemistry, 23(13), 3796-3808 (2015-04-22)
A novel series of TGX-221 analogues was prepared and tested for their potency against the p110α, p110β, and p110δ isoforms of the PI3K enzyme, and in two cellular assays. The biological results were interpreted in terms of a p110β comparative
Cuiping Fu et al.
International journal of biological macromolecules, 79, 235-239 (2015-05-10)
Calcineurin (CN) is a Ca(2+)/calmodulin (CaM) activated serine/threonine phosphatase, and its regulatory region (CNRR) plays a critical role in the coupling of Ca(2+) signals to cellular responses. Ca(2+)/CaM binds to the CNRR, resulting in a conformational change that removes an
Denis G Knyazev et al.
The Journal of biological chemistry, 289(35), 24611-24616 (2014-07-13)
While engaged in protein transport, the bacterial translocon SecYEG must maintain the membrane barrier to small ions. The preservation of the proton motif force was attributed to (i) cation exclusion, (ii) engulfment of the nascent chain by the hydrophobic pore
Bhagawatilal Jagetiya et al.
Chemosphere, 91(5), 692-696 (2012-12-27)
A greenhouse experiment was set up to investigate the ability of citric acid (CA), oxalic acid (OA), nitrilotriacetic acid (NTA) and EDTA for phytoremediation of uranium tailings by Indian mustard [Brassica juncea (L.) Czern. et Coss]. Uranium tailings were collected
Jianbo Yang et al.
The Biochemical journal, 470(1), 77-90 (2015-08-08)
In the brush border of intestinal and kidney epithelial cells, scaffolding proteins ezrin, Na(+)-H(+) exchanger regulatory factor (NHERF)1 and NHERF2 play important roles in linking transmembrane proteins to the cytoskeleton and assembling signalling regulatory complexes. The last 30 carboxyl residues
Richard Lu et al.
PLoS pathogens, 11(10), e1005200-e1005200 (2015-10-17)
The intracellular bacterial pathogen Shigella infects and spreads through the human intestinal epithelium. Effector proteins delivered by Shigella into cells promote infection by modulating diverse host functions. We demonstrate that the effector protein OspB interacts directly with the scaffolding protein
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