PHR1104

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显示 1-30 共 188 条结果关于 "PHR1104" 范围论文

Atypical antipsychotic drug treatment for 6 months restores N-acetylaspartate in left prefrontal cortex and left thalamus of first-episode patients with early onset schizophrenia: A magnetic resonance spectroscopy study.

Jing-Li Gan et al.

Psychiatry research, 223(1), 23-27 (2014-05-17)

Early onset schizophrenia (EOS) is often associated with poorer outcomes, including lack of school education, higher risk of mental disability and resistance to treatment. But the knowledge of the neurobiological mechanism of EOS is limited. Here, using proton magnetic resonance

Patient and tumor characteristics and BRAF and KRAS mutations in colon cancer, NCCTG/Alliance N0147.

Wilson I Gonsalves et al.

Journal of the National Cancer Institute, 106(7), doi:10-doi:10 (2014-06-14)

KRAS and BRAF (V600E) mutations are important predictive and prognostic markers, respectively, in colon cancer, but little is known about patient and clinical factors associated with them. Two thousand three hundred twenty-six of 3397 patients in the N0147 phase III

Novel hypoglycemic injury mechanism: N-methyl-D-aspartate receptor-mediated white matter damage.

Xin Yang et al.

Annals of neurology, 75(4), 492-507 (2013-11-19)

Hypoglycemia is a common adverse event and can injure central nervous system (CNS) white matter (WM). We determined whether glutamate receptors were involved in hypoglycemic WM injury. Mouse optic nerves (MON), CNS WM tracts, were maintained at 37°C with oxygenated

The pharmacologic modulation of 5-fluorouracil with folinic acid, methotrexate, trimetrexate, and n-phosphonacetyl-l-aspartic acid (PALA). Mechanisms of the interactions and clinical data.

D Machover

Bulletin du cancer, 81 Suppl 2, 74s-77s (1994-12-01)

An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation.

Jenna Friedt et al.

Nucleic acids research, 42(6), 3857-3870 (2013-12-29)

Pseudouridine synthases introduce the most common RNA modification and likely use the same catalytic mechanism. Besides a catalytic aspartate residue, the contributions of other residues for catalysis of pseudouridine formation are poorly understood. Here, we have tested the role of

Strategy for the estimation of chronological age using the aspartic acid racemization method with special reference to coefficient of correlation between D/L ratios and ages.

Susumu Ohtani et al.

Journal of forensic sciences, 50(5), 1020-1027 (2005-10-18)

The estimation of chronological age has been performed by various methods in forensic science. Among these, racemization methods, which are based on the age-dependent non-enzymatic changes of L-form amino acids to D-form mainly using aspartic acid, are one of the

Early MRI in term infants with perinatal hypoxic-ischaemic brain injury: interobserver agreement and MRI predictors of outcome at 2 years.

S K Goergen et al.

Clinical radiology, 69(1), 72-81 (2013-11-12)

To compare diffusion-weighted imaging (DWI) and non-DWI magnetic resonance imaging (MRI), proton MR spectroscopy (1H-MRS), and clinical biomarkers for prediction of 2 year developmental outcome in term infants with perinatal hypoxic-ischaemic encephalopathy (HIE). Nineteen infants ≥36 weeks gestation with HIE

White matter NAA/Cho and Cho/Cr ratios at MR spectroscopy are predictive of motor outcome in preterm infants.

Giles S Kendall et al.

Radiology, 271(1), 230-238 (2014-01-31)

To determine (a) whether diffuse white matter injury of prematurity is associated with an increased choline (Cho)-to-creatine (Cr) ratio and a reduced N-acetylaspartate (NAA)-to-Cho ratio and whether these measures can be used as biomarkers of outcome and (b) if changes

Pentosidine and N(epsilon)-(carboxymethyl)-lysine in Alzheimer's disease and vascular dementia.

K J Bär et al.

Neurobiology of aging, 24(2), 333-338 (2002-12-25)

Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of

Pathophysiology of hepatic encephalopathy: a new look at ammonia.

Roger F Butterworth

Metabolic brain disease, 17(4), 221-227 (2003-02-27)

Results of neuropathologic, spectroscopic, and neurochemical studies continue to confirm a major role for ammonia in the pathogenesis of the central nervous system complications of both acute and chronic liver failure. Damage to astrocytes characterized by cell swelling (acute liver

Determination of allelic expression of SNP rs1880676 in choline acetyltransferase gene in HeLa cells.

Zhongli Yang et al.

Neuroscience letters, 555, 215-219 (2013-10-01)

Recently, we reported that several polymorphisms and haplotypes in the choline acetyltransferase gene (ChAT) are associated with nicotine dependence (ND). Of them, SNP rs1880676 is of particular interest because: (1) it is a non-synonymous variant located in the coding region

Standard role for a conserved aspartate or more direct involvement in deglycosylation? An ONIOM and MD investigation of adenine-DNA glycosylase.

Jennifer L Kellie et al.

Biochemistry, 52(48), 8753-8765 (2013-10-31)

8-Oxoguanine (OG) is one of the most frequently occurring forms of DNA damage and is particularly deleterious since it forms a stable Hoogsteen base pair with adenine (A). The repair of an OG:A mispair is initiated by adenine-DNA glycosylase (MutY)

Intrathecal ultra-low dose naloxone enhances the antihyperalgesic effects of morphine and attenuates tumor necrosis factor-α and tumor necrosis factor-α receptor 1 expression in the dorsal horn of rats with partial sciatic nerve transection.

Chih-Ping Yang et al.

Anesthesia and analgesia, 117(6), 1493-1502 (2013-11-22)

Glutamate homeostasis and microglia activation play an important role in the development and maintenance of neuropathic pain. We designed this investigation to examine whether ultra-low dose naloxone administered alone or in combination with morphine could alter the concentration of the

A review of the methodological aspects of aspartic acid racemization analysis for use in forensic science.

E R Waite et al.

Forensic science international, 103(2), 113-124 (1999-09-11)

Accurate age determination of adult cadavers and human remains is a key requirement in forensic practice. The current morphological methods lack accuracy and precision, require specialist training and are costly. The use of aspartic acid racemization (AAR) in human dentine

Evaluation of the lactate-to-N-acetyl-aspartate ratio defined with magnetic resonance spectroscopic imaging before radiation therapy as a new predictive marker of the site of relapse in patients with glioblastoma multiforme.

Alexandra Deviers et al.

International journal of radiation oncology, biology, physics, 90(2), 385-393 (2014-08-12)

Because lactate accumulation is considered a surrogate for hypoxia and tumor radiation resistance, we studied the spatial distribution of the lactate-to-N-acetyl-aspartate ratio (LNR) before radiation therapy (RT) with 3D proton magnetic resonance spectroscopic imaging (3D-(1)H-MRSI) and assessed its impact on

Direct metal recognition by guanine nucleotide-exchange factor in the initial step of the exchange reaction.

Tamami Uejima et al.

Acta crystallographica. Section D, Biological crystallography, 69(Pt 3), 345-351 (2013-03-23)

Rab small GTPases regulate vesicle transport in eukaryotes by interacting with various effectors. Guanine nucleotide-exchange factor (GEF) catalyzes the transition from inactive GDP-bound Rab to active GTP-bound Rab. The existence of several GDP-bound intermediates containing the Arabidopsis thaliana Rab5 homologue

The measurement of 1,2-propanediol, D, L-2,3-butanediol and meso-2,3-butanediol in controls and alcoholic cirrhotics.

J P Casazza et al.

Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1, 607-609 (1987-01-01)

Plasma 1,2-propanediol, D,L,-2,3-butanediol and 2,3-meso-butanediol were measured in 29 patients with biopsy proven alcoholic cirrhosis and 10 control subjects, none of whom had measurable blood alcohol levels. None of these compounds were present in control subjects at level above 5

Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects.

J K Nicholson et al.

The Biochemical journal, 217(2), 365-375 (1984-01-15)

Resonances for the ketone bodies 3-D-hydroxybutyrate, acetone and acetoacetate are readily detected in serum, plasma and urine samples from fasting and diabetic subjects by 1H n.m.r. spectroscopy at 400 MHz. Besides the simultaneous observation of metabolites, the major advantage of

[I/D angiotensin-converting enzyme gene polymorphism: structural changes in the myocardium and predictive value in chronic heart failure].

L H Voronkov et al.

Likars'ka sprava, (8)(8), 36-42 (2013-06-22)

The article presents data regarding links of I/D angiotensin-converting enzyme (ACE) gene polymorphism and structural changes in the myocardium and predictive value in chronic heart failure (CHF). We did not find association of I/D ACE gene polymorphism and structural changes

No increase in bleeding identified in type 1 VWD subjects with D1472H sequence variation.

Veronica H Flood et al.

Blood, 121(18), 3742-3744 (2013-03-23)

The diagnosis of von Willebrand disease (VWD) is complicated by issues with current laboratory testing, particularly the ristocetin cofactor activity assay (VWF:RCo). We have recently reported a sequence variation in the von Willebrand factor (VWF) A1 domain, p.D1472H (D1472H), associated

Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients.

Anna Walter et al.

Neurobiology of aging, 25(10), 1299-1303 (2004-10-07)

Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF).

Activation of N-methyl-d-aspartate receptor downregulates inflammasome activity and liver inflammation via a β-arrestin-2 pathway.

Ahmad Farooq et al.

American journal of physiology. Gastrointestinal and liver physiology, 307(7), G732-G740 (2014-08-12)

Activation of the cytosolic inflammasome machinery is responsible for acute and chronic liver inflammation, but little is known about its regulation. The N-methyl-d-aspartate (NMDA) receptor families are heterotetrameric ligand-gated ion channels that are activated by a range of metabolites, including

Volumetric spectroscopic imaging of glioblastoma multiforme radiation treatment volumes.

N Andres Parra et al.

International journal of radiation oncology, biology, physics, 90(2), 376-384 (2014-07-30)

Magnetic resonance (MR) imaging and computed tomography (CT) are used almost exclusively in radiation therapy planning of glioblastoma multiforme (GBM), despite their well-recognized limitations. MR spectroscopic imaging (MRSI) can identify biochemical patterns associated with normal brain and tumor, predominantly by

Evaluation of enantiomeric purity of magnesium-L-aspartate dihydrate.

Oliver Wahl et al.

Journal of pharmaceutical and biomedical analysis, 102, 100-109 (2014-09-30)

Magnesium supplementation in form of organic magnesium salts is a very popular practice. We examined the enantiomeric purity of "Magnesium aspartate dihydrate" monographed in the European Pharmacopeia. A chiral capillary zone electrophoresis using (2-hydroxypropyl)-β-cyclodextrin coupled to laser induced fluorescence detection

Capillary electrophoresis with laser-induced fluorescence detection for studying amino acid uptake by yeast during beer fermentation.

Heidi Turkia et al.

Talanta, 131, 366-371 (2014-10-05)

The amino acid composition of cultivation broth is known to affect the biomass accumulation, productivity, and vitality of yeast during cultivation. A separation method based on capillary electrophoresis with laser-induced fluorescence (LIF) detection was developed for the determination of amino

Racemization of aspartic acid in human proteins.

Stefanie Ritz-Timme et al.

Ageing research reviews, 1(1), 43-59 (2002-06-01)

Aspartic acid racemization (AAR) represents one of the major types of non-enzymatic covalent modification that leads to an age-dependent accumulation of abnormal protein in numerous human tissues. In vivo racemization is an autonomic process during the "natural" ageing of proteins

Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks.

Edi Erwan et al.

Life sciences, 109(1), 65-71 (2014-06-03)

L-Aspartate (L-Asp) and D-aspartate (D-Asp) are physiologically important amino acids in mammals and birds. However, the functions of these amino acids have not yet been fully understood. In this study, we therefore examined the effects of L-Asp and D-Asp in

Delayed pharyngeal repolarization promotes abnormal calcium buildup in aging muscle.

Przemyslaw Swiatkowski et al.

Biochemical and biophysical research communications, 433(3), 354-357 (2013-03-21)

In the pharynx of Caenorhabditis elegans, the accessory subunit MPS-4, homolog to human KCNE1, forms a complex with K(+) channel EXP-2 that terminates the action potential. An aspartate residue critical for KCNE1 function, asp76, is conserved in MPS-4 (asp74). Here

Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease.

Takashi Abe et al.

Journal of neuroscience research, 70(3), 447-450 (2002-10-23)

To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with AD and

Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment.

C Härnryd et al.

Psychopharmacology, 64(2), 131-134 (1979-08-08)

The effect of ECT on concentrations of monoamine metabolites in lumbar CSF of psychotic women with a schizophrenic symptomatology was examined. After a series of ECT there was a significant reduction of the concentration of the major noradrenaline metabolite, MOPEG.

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