CN
Search Within
PHR1233
应用筛选条件
关键词:'PHR1233'
显示 1-30 共 120 条结果 关于 "PHR1233" 范围 论文
Ling-Xiao Deng et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5655-5667 (2013-03-29)
Descending propriospinal neurons (DPSN) are known to establish functional relays for supraspinal signals, and they display a greater growth response after injury than do the long projecting axons. However, their regenerative response is still deficient due to their failure to
Friedrich Finkenwirth et al.
Journal of bacteriology, 195(18), 4105-4111 (2013-07-10)
Energy-coupling factor (ECF) transporters form a large group of vitamin uptake systems in prokaryotes. They are composed of highly diverse, substrate-specific, transmembrane proteins (S units), a ubiquitous transmembrane protein (T unit), and homo- or hetero-oligomeric ABC ATPases. Biotin transporters represent
Kai Zhang et al.
Biosensors & bioelectronics, 49, 226-230 (2013-06-19)
In this work, we report a thrombin binding aptamer complex based time-resolved fluorescence sensor for small molecule detection. The sensor employs two strands (DNA1 and DNA2) of oligonucleotides. This two strands of oligonucleotides contain two aptamer (α-aptamer and β-aptamer) respectively.
Timothy H Tran et al.
Nature, 518(7537), 120-124 (2014-11-11)
Biotin-dependent carboxylases are widely distributed in nature and have important functions in the metabolism of fatty acids, amino acids, carbohydrates, cholesterol and other compounds. Defective mutations in several of these enzymes have been linked to serious metabolic diseases in humans
James A Corson et al.
The Journal of comparative neurology, 521(13), 2907-2926 (2013-05-04)
Physiological studies suggest convergence of chorda tympani and glossopharyngeal afferent axons onto single neurons of the rostral nucleus of the solitary tract (rNTS), but anatomical evidence has been elusive. The current study uses high-magnification confocal microscopy to identify putative synaptic
Question 2. What is the incidence of biotin deficiency in preschool children with global developmental delay?
Michael O Ogundele
Archives of disease in childhood, 96(9), 895-897 (2011-08-13)
Nongyue He et al.
Journal of biomedical nanotechnology, 9(2), 267-273 (2013-05-01)
Molecular detection of HBV has a significant impact on prognosis and therapy of the disease. In this paper, a sensitive nucleic acid detection method of HBV was established taking advantage of magnetic nanoparticles (MNPs), chemiluminescence (CL) and polymerase chain reaction
Belén Pérez-Dueñas et al.
Pediatrics, 131(5), e1670-e1675 (2013-04-17)
Thiamine transporter-2 deficiency is a recessive disease caused by mutations in the SLC19A3 gene. Patients manifest acute episodes of encephalopathy; symmetric lesions in the cortex, basal ganglia, thalami or periaqueductal gray matter, and a dramatic response to biotin or thiamine.
Elenia Cinelli et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(21), 9104-9112 (2013-05-24)
A brainstem region, the paratrigeminal respiratory group (pTRG), has been suggested to play a crucial role in the respiratory rhythm generation in lampreys. However, a detailed characterization of the pTRG region is lacking. The present study performed on isolated brainstem
Isabel Márquez-Sillero et al.
Journal of chromatography. A, 1313, 253-258 (2013-06-04)
A simple and rapid method for the simultaneous determination of seven water-soluble vitamins (thiamine, folic acid, nicotinic acid, ascorbic acid, pantothenic acid, pyridoxine and biotin) was developed by high performance liquid chromatographic separation and corona-charged aerosol detection. The water-soluble vitamins
Abdussalam Adina-Zada et al.
Biochemical Society transactions, 40(3), 567-572 (2012-05-24)
The activity of the biotin-dependent enzyme pyruvate carboxylase from many organisms is highly regulated by the allosteric activator acetyl-CoA. A number of X-ray crystallographic structures of the native pyruvate carboxylase tetramer are now available for the enzyme from Rhizobium etli
Shigehiro Takahashi et al.
Analytical and bioanalytical chemistry, 402(5), 1749-1758 (2011-08-26)
In this review, the preparation and properties of protein architectures constructed by layer-by-layer (LbL) deposition through avidin-biotin and concanavalin A (Con A)-sugar interactions are discussed in relation to their use for optical and electrochemical biosensors. LbL films can be constructed
Konstantinos Ampatzis et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(26), 10875-10886 (2013-06-28)
In vertebrates, spinal circuits drive rhythmic firing in motoneurons in the appropriate sequence to produce locomotor movements. These circuits become active early during development and mature gradually to acquire the flexibility necessary to accommodate the increased behavioral repertoire of adult
Franziska Grafe et al.
The Journal of investigative dermatology, 120(3), 428-433 (2003-02-27)
Biotin is an essential micronutrient for normal cellular function, growth, and development. Biotin deficiency leads to pathologic, dermatologic, and neurocutaneous manifestations in skin and its appendages. Previous studies described the presence of specific biotin transport systems in the epithelia of
Georgia Thodi et al.
Gene, 524(2), 361-362 (2013-05-07)
Biotinidase deficiency (BTD) is an inherited disorder with severe clinical manifestations if not treated early. 63,119 neonates were tested for BTD according to a 3-step protocol. Biotinidase activity was initially estimated through standard colorimetric method on dried blood spots, then
Dae-Sung Lee et al.
The Analyst, 138(17), 4786-4794 (2013-07-16)
Amyloid-like protein nanofibers were assembled in vitro using a recombinant protein fusion, with yeast Sup35 and human SSB/La proteins as assembly units, where the length of the nanofibers was mostly between 100 and 400 nm. The protein nanofibers, hereafter referred
Juha A E Määttä et al.
BMC structural biology, 9, 63-63 (2009-10-01)
Avidins are proteins with extraordinarily high ligand-binding affinity, a property which is used in a wide array of life science applications. Even though useful for biotechnology and nanotechnology, the biological function of avidins is not fully understood. Here we structurally
Andrew L Garfoot et al.
Infection and immunity, 82(1), 393-404 (2013-11-06)
During infection of the mammalian host, Histoplasma capsulatum yeasts survive and reside within macrophages of the immune system. Whereas some intracellular pathogens escape into the host cytosol, Histoplasma yeasts remain within the macrophage phagosome. This intracellular Histoplasma-containing compartment imposes nutritional
Cydne A Perry et al.
The Journal of nutrition, 144(12), 1977-1984 (2014-08-15)
Biotin functions as a cofactor for several carboxylase enzymes with key roles in metabolism. At present, the dietary requirement for biotin is unknown and intake recommendations are provided as Adequate Intakes (AIs). The biotin AI for adults and pregnant women
D Vukosavljevic et al.
Journal of dental research, 93(5), 514-519 (2014-03-05)
The acquired enamel pellicle (AEP) is important for minimizing the abrasion caused by parafunctional conditions as they occur, for instance, during bruxism. It is a remarkable feature of the AEP that a protein/peptide film can provide enough protection in normofunction
R Pellicano et al.
Minerva gastroenterologica e dietologica, 60(4), 263-268 (2014-11-12)
Functional dyspepsia, though benign, leads to deterioration of the quality of life and high costs for healthcare systems. The optimal therapy for functional dyspepsia is still to be defined because of its multifactorial pathogenesis. In an open multicentric study of
Janos Zempleni et al.
BioFactors (Oxford, England), 35(1), 36-46 (2009-03-26)
Biotin is a water-soluble vitamin and serves as a coenzyme for five carboxylases in humans. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin structure and mediating gene regulation. This review describes mammalian biotin metabolism, biotin
Corey J Fugate et al.
Biochimica et biophysica acta, 1824(11), 1213-1222 (2012-02-14)
The enzyme cofactor and essential vitamin biotin is biosynthesized in bacteria, fungi, and plants through a pathway that culminates with the addition of a sulfur atom to generate the five-membered thiophane ring. The immediate precursor, dethiobiotin, has methylene and methyl
Stuart Trenholm et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(37), 14927-14938 (2013-09-13)
Recently, we demonstrated that gap junction coupling in the population of superior coding ON-OFF directionally selective ganglion cells (DSGCs) genetically labeled in the Hb9::eGFP mouse retina allows the passage of lateral anticipatory signals that help track moving stimuli. Here, we
D M Mock et al.
The Journal of nutrition, 131(8), 2208-2214 (2001-08-02)
In human urine, the biotin concentration assayed directly using an avidin-binding assay (ABA) apparently overestimates "true" biotin concentration as measured by HPLC separation of biotin from biotin metabolites followed by ABA. Because biotin metabolites account for about half of biotin
Kelli G Sharp et al.
Experimental neurology, 257, 186-204 (2014-04-22)
As part of the NIH "Facilities of Research Excellence-Spinal Cord Injury" project to support independent replication, we repeated key parts of a study reporting robust engraftment of neural stem cells (NSCs) treated with growth factors after complete spinal cord transection
Sung Jae Shin et al.
Clinical and vaccine immunology : CVI, 15(8), 1277-1281 (2008-06-14)
We previously reported that protein antigens of serodiagnostic potential were more abundant in culture filtrates than cellular extracts from liquid cultures of Mycobacterium avium subsp. paratuberculosis (D. Cho and M. T. Collins, Clin. Vaccine Immunol. 13:1155-1161, 2006). Based on this
G Dolton et al.
Clinical and experimental immunology, 177(1), 47-63 (2014-03-29)
Fluorochrome-conjugated peptide-major histocompatibility complex (pMHC) multimers are widely used for flow cytometric visualization of antigen-specific T cells. The most common multimers, streptavidin-biotin-based 'tetramers', can be manufactured readily in the laboratory. Unfortunately, there are large differences between the threshold of T
A substrate-induced biotin binding pocket in the carboxyltransferase domain of pyruvate carboxylase.
Adam D Lietzan et al.
The Journal of biological chemistry, 288(27), 19915-19925 (2013-05-24)
Biotin-dependent enzymes catalyze carboxyl transfer reactions by efficiently coordinating multiple reactions between spatially distinct active sites. Pyruvate carboxylase (PC), a multifunctional biotin-dependent enzyme, catalyzes the bicarbonate- and MgATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in mammalian tissues.
Wataru Fujimoto et al.
The Journal of dermatology, 32(4), 256-261 (2005-05-03)
Biotin deficiency is rarely encountered in an infant on weaning from breast and formula feeding. It is characterized by alopecia and scaly, erythematous dermatitis distributed around the body orifices. We report a 5-month-old Japanese infant with typical skin lesions who
1/4