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Bih-Show Lou et al.
Journal of pharmaceutical and biomedical analysis, 94, 99-105 (2014-02-25)
A rapid, sensitive, and selective ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) in the multiple reaction monitoring (MRM) mode has been developed and validated to investigate the distribution of trans-Resveratrol (Resv) and its metabolites in rats following intravenous (IV) administration
Shu Zhu et al.
Thrombosis research, 134(6), 1335-1343 (2014-10-12)
Generation of active Factor XII (FXIIa) triggers blood clotting on artificial surfaces and may also enhance intravascular thrombosis. We developed a patterned kaolin (0 to 0.3 pg/μm(2))/type 1 collagen fibril surface for controlled microfluidic clotting assays. Perfusion of whole blood
Sasidharan Nishanth Kumar et al.
PloS one, 9(8), e106041-e106041 (2014-08-27)
The rhabditid entomopathogenic nematode associated Bacillus cereus and the antifungal compounds produced by this bacterium were evaluated for their activity in reducing postharvest decay of peanut kernels caused by Aspergillus species in in vitro and in vivo tests. The results
Santiago Lima et al.
Journal of lipid research, 55(7), 1525-1530 (2014-05-06)
Sphingosine kinases (SphKs), of which there are two isoforms, SphK1 and SphK2, have been implicated in regulation of many important cellular processes. We have developed an assay for monitoring SphK1 and SphK2 activity in real time without the need for
Olivia Candini et al.
Stem cells (Dayton, Ohio), 33(3), 939-950 (2014-11-28)
Human aging is associated with a decrease in tissue functions combined with a decline in stem cells frequency and activity followed by a loss of regenerative capacity. The molecular mechanisms behind this senescence remain largely obscure, precluding targeted approaches to
Hui Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965, 91-99 (2014-07-08)
Diaveridine (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide. It has been reported to be genotoxic to mammalian cells, but more studies are required to clarify this. Moreover, there is very little information on
Rita Celano et al.
Journal of chromatography. A, 1355, 26-35 (2014-06-19)
Pharmaceutical and personal care products (PPCPs) are one of the most important classes of emerging contaminants. The potential of ecological and environmental impacts associated with PPCPs are of particular concern because they continually penetrate the aquatic environment. This work describes
Satish K Chitneni et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 55(7), 1192-1197 (2014-05-24)
The availability of (18)F-labeled and unlabeled 2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5) allows for a comparative assessment of tumor hypoxia by PET and immunohistochemistry; however, the combined use of these 2 approaches has not been fully assessed in vivo. The aim of this study
Takaki Amamoto et al.
Chemical & pharmaceutical bulletin, 62(7), 649-653 (2014-07-06)
We have developed a general method for controlling molecular functions using a photodegradable hydrogel; gels containing molecules made from such materials are capable of release and activation by light stimulus. As the elimination of molecular leaching from the gel before
Iman Chouikha et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(52), 18709-18714 (2014-12-03)
The arthropod-borne transmission route of Yersinia pestis, the bacterial agent of plague, is a recent evolutionary adaptation. Yersinia pseudotuberculosis, the closely related food-and water-borne enteric species from which Y. pestis diverged less than 6,400 y ago, exhibits significant oral toxicity
Hak Suk Chung et al.
Biochemical and biophysical research communications, 452(3), 789-794 (2014-09-11)
The lipopolysaccharide (LPS) isolated from certain important Gram-negative pathogens including a human pathogen Yersinia pestis and opportunistic pathogens Burkholderia mallei and Burkholderia pseudomallei contains d-glycero-d-talo-oct-2-ulosonic acid (Ko), an isosteric analog of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo). Kdo 3-hydroxylase (KdoO), a Fe(2+)/α-KG/O2 dependent
Song Gao et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 986-987, 54-59 (2015-02-24)
The purpose of this study is to develop and validate an UPLC-MS/MS method to quantify ethoxzolamide in plasma (EZ) and apply the method to absorption, brain distribution, as well as pharmacokinetic studies. A C₁₈ column was used with 0.1% of
Yusuke Matsuya et al.
Journal of radiation research, 56(1), 90-99 (2014-10-31)
We have investigated the dose rate effects on cell damage caused by photon-beam irradiation. During a relatively long dose-delivery time with a low dose rate, lesions created in cells may undergo some reactions, such as DNA repair. In order to
Marco A Campinho et al.
Molecular endocrinology (Baltimore, Md.), 28(7), 1136-1149 (2014-06-01)
Teleost eggs contain an abundant store of maternal thyroid hormones (THs), and early in zebrafish embryonic development, all the genes necessary for TH signaling are expressed. Nonetheless the function of THs in embryonic development remains elusive. To test the hypothesis
Jung-Woo Chae et al.
Drug development and industrial pharmacy, 40(10), 1325-1329 (2013-07-28)
The study of pharmacokinetics of alendronate has been hampered by difficulties in accurately and reproducibly determining their concentrations in serum and urine. Thus, pharmacokinetic characteristics of alendronate have been described in many reports based on urinary excretion data; and plasma
Pin Lv et al.
Food chemistry, 174, 52-59 (2014-12-23)
Changes in carotenoid profiles during fruit ripening were investigated in four watermelon cultivars: red-fleshed "CN66", pink-fleshed "CN62", yellow-fleshed "ZXG381" and white-fleshed "ZXG507". The expression pattern of twelve genes (GGPS, PSY, PSY-A, PDS, ZDS, CRTISO, LCYB, CHYB, ZEP, NCED1, NCED2 and
Feng Zhang et al.
Molecular bioSystems, 10(8), 2055-2063 (2014-05-20)
Shengxian Decoction (SXT), a classic Traditional Chinese Medicine (TCM) prescription, consists of five TCMs: Astragali Radix, Anemarrhenae Rhizoma, Bupleuri Radix, Platycodonis Radix (PG), and Cimicifugae Rhizoma. SXT has been demonstrated to show good therapeutic effects on the cardiovascular system. A
Nadia Djabrouhou et al.
Journal of pharmaceutical and biomedical analysis, 100, 11-20 (2014-08-15)
This paper describes a new LC-MS/TOF method for the degradation products determination when Etifoxine (ETI) is submitted to different stress conditions. Chromatography is performed by using Kromasil C18 column (250mm×4.6mm, 5μm particle size). The selected mobile phase consists of formate
Daryn Goodwin et al.
Vaccine, 33(12), 1453-1458 (2015-02-14)
Immunocastration using gonadotropin-releasing hormone (GnRH)-based vaccines has been investigated in rams to reduce aggressive and sexual behaviour and to control meat quality. Despite considerable efforts, a practical GnRH vaccine has yet to be developed for rams. In the present study
S Echeverría et al.
Analytica chimica acta, 844, 75-79 (2014-08-31)
Pressurized liquid extraction (PLE) has been successfully applied for the first time to the extraction of five iodinated X-ray contrast media from sludge. Once optimized all PLE parameters, the extract has been analyzed by liquid chromatography-tandem mass spectrometry, being the
Izaskun Valdivielso et al.
Food chemistry, 173, 709-717 (2014-12-04)
Carotenoids and tocopherols from botanical species abundant in Atlantic mountain grasslands were simultaneously extracted using one-step solid-liquid phase. A single n-hexane/2-propanol extract containing both types of compounds was injected twice under two different sets of HPLC conditions to separate the
Monika Musko et al.
Acta pharmaceutica (Zagreb, Croatia), 64(4), 463-474 (2014-12-23)
Available tablets or capsules for adults are often used to prepare extemporaneously formulated medicines appropriate for children. The most acceptable drug forms in pediatric population are oral liquids and pharmacists use commercial dispersing media to compound syrups from an active
S Kmoch et al.
Nature communications, 6, 5614-5614 (2015-01-13)
Blindness due to retinal degeneration affects millions of people worldwide, but many disease-causing mutations remain unknown. PNPLA6 encodes the patatin-like phospholipase domain containing protein 6, also known as neuropathy target esterase (NTE), which is the target of toxic organophosphates that
Christian Zorzetto et al.
Fitoterapia, 100, 95-109 (2014-12-03)
In the present work we carried out a phytochemical and biological investigation on three Hypericum species, i.e. Hypericum reflexum, Hypericum canariense and Hypericum grandifolium, from the Canary Islands where they are traditionally used as diuretic, wound healing, vermifuge, sedative and
Angela Mari et al.
Journal of pharmaceutical and biomedical analysis, 102, 215-221 (2014-10-12)
Food supplements based on Vitex agnus castus L. (Verbenaceae) fruits, also known as chasteberry, are routinely used by women against somatic and psychic premenstrual symptoms such as depression, sadness or irritability. With the aim of highlighting the differences in the
Marjory Moreau et al.
Journal of toxicology and environmental health. Part A, 78(3), 166-184 (2014-12-17)
The effects of benzo[a]pyrene (BaP) administration on biomarkers of exposure and early effects were studied in male Sprague-Dawley rats intravenously injected with doses of 0.4, 4, 10, or 40 μmol BaP/kg . Blood, tissues, and excreta were collected 8 and
Marie Korostelev et al.
Journal of pharmaceutical and biomedical analysis, 100, 230-235 (2014-09-01)
A sensitive and accurate liquid chromatography method with mass spectrometry detection was developed and validated for the quantification of dabigatran (Pradaxa(®)) and rivaroxaban (Xarelto(®)). (13)C6-dabigatran and (13)C6-rivaroxaban were used as the internal standard. A single-step protein precipitation was used for
Marina Makrecka et al.
Molecular and cellular biochemistry, 395(1-2), 1-10 (2014-06-01)
In the heart, a nutritional state (fed or fasted) is characterized by a unique energy metabolism pattern determined by the availability of substrates. Increased availability of acylcarnitines has been associated with decreased glucose utilization; however, the effects of long-chain acylcarnitines
Quan Liu et al.
Journal of agricultural and food chemistry, 62(34), 8555-8561 (2014-08-05)
Weed infestation has been known to cause considerable reductions in crop yields, thereby hindering sustainable agriculture. Many plants in genus Euphorbia affect neighboring plants and other organisms by releasing chemicals into the environment. In view of the serious threat of
Kati Hanhineva et al.
The Journal of nutrition, 145(1), 7-17 (2014-12-21)
Nontargeted metabolite profiling allows for concomitant examination of a wide range of metabolite species, elucidating the metabolic alterations caused by dietary interventions. The aim of the current study was to investigate the effects of dietary modifications on the basis of
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