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On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death.
Zilka O, et al.
ACS central science, 3(3), 232-243 (2017)
Yuko Iida et al.
Oncology letters, 21(1), 71-71 (2020-12-29)
Small-cell lung cancer (SCLC) is a highly aggressive cancer with poor prognosis, due to a lack of therapeutic targets. Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables and has shown anticancer effects against numerous types of cancer. However, its
I?-Synuclein Attenuates Maneb Neurotoxicity through the Modulation of Redox-Sensitive Transcription Factors.
Conde, et al.
Oxidative Medicine and Cellular Longevity, 2023, 5803323-5803323 (2023)
Pengfei Liu et al.
Redox biology, 59, 102570-102570 (2022-12-11)
Caloric excess and sedentary lifestyles have led to an epidemic of obesity, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD). The objective of this study was to investigate the mechanisms underlying high fat diet (HFD)-induced NAFLD, and to explore NRF2
Roberta Noè et al.
Redox biology, 68, 102962-102962 (2023-11-29)
Pancreatic ductal adenocarcinoma (PDA) cells reprogram both mitochondrial and lysosomal functions to support growth. At the same time, this causes significant dishomeostasis of free radicals. While this is compensated by the upregulation of detoxification mechanisms, it also represents a potential
Mizanur Rahman et al.
Scientific reports, 12(1), 16396-16396 (2022-10-01)
Heated tobacco products (HTP) are novel nicotine delivery products with limited toxicological data. HTP uses heating instead of combustion to generate aerosol (HTP-smoke). Physiologically relevant human bronchial and alveolar lung mucosa models developed at air-liquid interface were exposed to HTP-smoke
Marcos A Perez et al.
Developmental cell, 54(4), 447-454 (2020-07-12)
Dietary lipids impact development, homeostasis, and disease, but links between specific dietary fats and cell fates are poorly understood. Ferroptosis is an iron-dependent form of nonapoptotic cell death associated with oxidized polyunsaturated phospholipids. Here, we show that dietary ingestion of
Kun Fang et al.
iScience, 25(7), 104618-104618 (2022-07-09)
Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-dependent lipid peroxidation. Cancer cells differ in their sensitivity to ferroptosis. Here we showed that the Suppressor of fused homolog (SUFU), a critical component in Hedgehog
Yao Tong et al.
Redox biology, 65, 102840-102840 (2023-08-11)
Oxidative stress is hypothesized to drive the progression of age-related macular degeneration (AMD). Retinal pigment epithelial (RPE) cell layer is important for supporting the function of retina and is particularly susceptible to oxidative stress-induced cell death. How RPE cells die
Jaeyoung Ha et al.
Communications biology, 4(1), 1123-1123 (2021-09-25)
The highly cytotoxic marine natural product callyspongiolide holds great promise as a warhead of antibody-drug conjugate in cancer therapeutics; however, the mechanism underlying its cytotoxicity remains unclear. To elucidate how callyspongiolide kills cells, we employed label-free target identification with thermal
Yanmei Yuan et al.
Journal of experimental & clinical cancer research : CR, 43(1), 133-133 (2024-05-03)
Targeting ferroptosis has been identified as a promising approach for the development of cancer therapies. Monounsaturated fatty acid (MUFA) is a type of lipid that plays a crucial role in inhibiting ferroptosis. Ficolin 3 (FCN3) is a component of the
Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques.
Puylaert, et al.
Angiogenesis (2023)
Di Wang et al.
Cell death and differentiation, 30(2), 369-382 (2022-11-29)
Ferroptosis is an iron-dependent cell death with the accumulation of lipid peroxidation and dysfunction of antioxidant systems. As the critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated to be down-regulated in amyotrophic lateral sclerosis (ALS). However, the mechanism of
Wen-Dai Bao et al.
Cell death and differentiation, 28(5), 1548-1562 (2021-01-06)
Iron homeostasis disturbance has been implicated in Alzheimer's disease (AD), and excess iron exacerbates oxidative damage and cognitive defects. Ferroptosis is a nonapoptotic form of cell death dependent upon intracellular iron. However, the involvement of ferroptosis in the pathogenesis of
Raj K Gopal et al.
Cancer discovery, 13(8), 1904-1921 (2023-06-01)
Oncocytic (Hürthle cell) carcinoma of the thyroid (HCC) is genetically characterized by complex I mitochondrial DNA mutations and widespread chromosomal losses. Here, we utilize RNA sequencing and metabolomics to identify candidate molecular effectors activated by these genetic drivers. We find
Magdalena Gryzik et al.
Biochimica et biophysica acta. Molecular cell research, 1868(2), 118913-118913 (2020-11-28)
Ferroptosis is a regulated cell death characterized by a lethal accumulation of lipid peroxides due to an increase of intracellular iron and a decrease of antioxidant capacity. The reduction of antioxidant activity is obtained by using chemical agents, such as
Rachel P L van Swelm et al.
Cell death & disease, 9(5), 550-550 (2018-05-12)
Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement
Hao Chen et al.
Biomolecules & biomedicine (2024-06-06)
Colorectal cancer (CRC) is one of the most common non-cutaneous malignancies, causing significant mortality and a substantial burden. This study aims to explore the role of KIAA1429 (also known as vir-like m6A methyltransferase associated [VIRMA]) protein in the radioresistance of
Xin Tang et al.
Thoracic cancer, 12(8), 1219-1230 (2021-03-04)
Emerging studies showed curcumin can inhibit glioblastoma and breast cancer cells via regulating ferroptosis. However, the role of ferroptosis in the inhibitory effect of curcumin on non-small-cell lung cancer (NSCLC) remains unclear. Cell counting kit-8 (CCK-8) assay was used to
Bruce Culbertson et al.
Nature cancer, 4(5), 682-698 (2023-05-12)
Antisense RNAs are ubiquitous in human cells, yet their role is largely unexplored. Here we profiled antisense RNAs in the MDA-MB-231 breast cancer cell line and its highly lung metastatic derivative. We identified one antisense RNA that drives cancer progression
Yingchao Wu et al.
Evidence-based complementary and alternative medicine : eCAM, 2022, 6177553-6177553 (2022-06-10)
Colorectal cancer (CRC) is a severe threat to human health. Ginsenosides such as ginsenoside Rh4 have been widely studied in the antitumor field. Here, we investigated the antiproliferative activity and mechanism of Rh4 against CRC in vivo and in vitro.
Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
Mai T T, et al.
Nature Chemistry, 9(10), 1025-1025 (2017)
Trang Thi Mai et al.
Nature chemistry, 9(10), 1025-1033 (2017-09-25)
Cancer stem cells (CSCs) represent a subset of cells within tumours that exhibit self-renewal properties and the capacity to seed tumours. CSCs are typically refractory to conventional treatments and have been associated to metastasis and relapse. Salinomycin operates as a
Yu Wang et al.
Frontiers in cardiovascular medicine, 10, 1157752-1157752 (2023-05-12)
The use of high-power microwave (HPM) in our daily live is becoming more and more widespread, but the safety has also caused our concern. And ferroptosis is a newly discovered modality that can regulate cell death in recent years. The
Yingchao Wu et al.
Acta biochimica et biophysica Sinica, 55(4), 587-600 (2023-04-24)
Ginsenoside Rh3 (GRh3) is a seminatural product obtained by chemical processing after isolation from Chinese herbal medicine that has strong antitumor activity against human tumors. However, its antitumor role remains to be elucidated. The aim of this study is to
Yu-An Kung et al.
mBio, e0271721-e0271721 (2022-01-19)
Enterovirus infections can cause severe complications, such as poliomyelitis, encephalitis, myocarditis, meningitis, neurological pulmonary edema, and even death. Here, we used genome-wide CRISPR screens to gain new insight into the mechanism by which enteroviruses co-opt host pathways to potentiate replication
Sanae Miyake et al.
Biochemical and biophysical research communications, 527(3), 839-844 (2020-05-21)
Apoptosis is the prototype for a regulated form of cell death, but recent studies have revealed other types of regulated forms of cell death, including necroptosis and ferroptosis. The molecular mechanisms underlying the execution of these processes have been intensively
Xiaoqin Li et al.
European journal of medical research, 27(1), 292-292 (2022-12-16)
Endometrial carcinoma (EC) is one of the most common female reproductive system tumors, which seriously threatens women's health. This preliminary study aimed to investigate the effects of quercetin on the EC cells and explore the potential mechanism. In this study
Ola Karmi et al.
Antioxidants (Basel, Switzerland), 10(8) (2021-08-28)
Decreased insulin secretion, associated with pancreatic β-cell failure, plays a critical role in many human diseases including diabetes, obesity, and cancer. While numerous studies linked β-cell failure with enhanced levels of reactive oxygen species (ROS), the development of diabetes associated
Lipid hydroperoxides promote sarcopenia through carbonyl stress.
Eshima, et al.
eLife, 12 (2023)
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