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P C Calder et al.
European journal of clinical nutrition, 56 Suppl 3, S14-S19 (2002-07-27)
Consumption of n-6 polyunsaturated fatty acids greatly exceeds that of n-3 polyunsaturated fatty acids. The n-6 polyunsaturated fatty acid arachidonic gives rise to the eicosanoid family of inflammatory mediators (prostaglandins, leukotrienes and related metabolites) and through these regulates the activities
Ambre M Bertholet et al.
Frontiers in physiology, 11, 326-326 (2020-05-01)
Mitochondria convert the chemical energy of metabolic substrates into adenosine triphosphate (ATP) and heat. Although ATP production has become a focal point of research in bioenergetics, mitochondrial thermogenesis is also crucial for energy metabolism. Mitochondria generate heat due to H+
Guilherme G Moreira et al.
Nature communications, 12(1), 6292-6292 (2021-11-03)
The microtubule-associated protein tau is implicated in the formation of oligomers and fibrillar aggregates that evade proteostasis control and spread from cell-to-cell. Tau pathology is accompanied by sustained neuroinflammation and, while the release of alarmin mediators aggravates disease at late
Eduardo Fuentes et al.
PloS one, 9(3), e90699-e90699 (2014-03-07)
Chlorogenic acid is a potent phenolic antioxidant. However, its effect on platelet aggregation, a critical factor in arterial thrombosis, remains unclear. Consequently, chlorogenic acid-action mechanisms in preventing platelet activation and thrombus formation were examined. Chlorogenic acid in a dose-dependent manner
J A Badwey et al.
The Journal of biological chemistry, 256(24), 12640-12643 (1981-12-25)
Arachidonate stimulates the production of large quantities of superoxide by human neutrophils: 93.8 +/- 12.5 S.D. nmol of O2(-)/min/10(7) cells. This rate is comparable to that observed with the most effective neutrophil-stimulating agents previously reported. Other cis-unsaturated fatty acids are
Olga Bondarenko et al.
FEBS letters, 593(14), 1735-1750 (2019-05-23)
During spermatogenesis, fatty acids play an important role both as structural components and messengers that trigger male germ cell line differentiation. The spontaneous oxidation of fatty acids causes a decrease in mammalian fertility. Here, we examine the effects of nonenzymatically
Anna Szóstek-Mioduchowska et al.
BMC veterinary research, 16(1), 343-343 (2020-09-19)
Equine endometrosis is a chronic degenerative condition, described as endometrial fibrosis that forms in the stroma, under the basement membrane and around the endometrial glands. The role of lysophosphatidic acid (LPA) in the development of tissue fibrosis varies depending on
Marta Riera-Borrull et al.
Journal of immunology (Baltimore, Md. : 1950), 199(11), 3858-3869 (2017-10-25)
Obesity is associated with low-grade inflammation and elevated levels of circulating saturated fatty acids, which trigger inflammatory responses by engaging pattern recognition receptors in macrophages. Because tissue homeostasis is maintained through an adequate balance of pro- and anti-inflammatory macrophages, we
Arachidonic acid as a bioactive molecule.
A R Brash
The Journal of clinical investigation, 107(11), 1339-1345 (2001-06-08)
L B Klickstein et al.
The Journal of clinical investigation, 66(5), 1166-1170 (1980-11-01)
The predominant lipoxygenase products of arachidonic acid were extracted and purified from synovial fluid and sonicates of synovial tissue of patients with rheumatoid arthritis (RA), spondyloarthritis (SA), or a noninflammatory arthropathy (NIA). The concentration of 5(S),12(R)-dihydroxy-6,8,10-(trans/trans/cis)-14-cis-eicosatetraenoic acid (leukotriene B4) in
S Araki et al.
Pflugers Archiv : European journal of physiology, 441(5), 596-603 (2001-04-11)
Arachidonic acid activates isolated Rho-kinase and contracts permeabilized smooth muscle fibres. Various assays were carried out to examine the mechanism of this activation. Native Rho-kinase was activated 5-6 times by arachidonic acid but an N-terminal, constitutively-active fragment of Rho-kinase, expressed
Arthur A Spector
Journal of lipid research, 50 Suppl, S52-S56 (2008-10-28)
Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acid (EET) regioisomers, 5,6-, 8,9-, 11,12-, and 14,15-EET, that function as autacrine and paracrine mediators. EETs produce vascular relaxation by activating smooth muscle large-conductance Ca2+-activated K+ channels (BKCa). In addition
Carlo Giorgio Barracchia et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-18)
The intrinsically disordered, amyloidogenic protein Tau associates with diverse classes of molecules, including proteins, nucleic acids, and lipids. Mounting evidence suggests that fatty acid molecules could play a role in the dysfunction of this protein, however, their interaction with Tau
Fumiaki Ando et al.
Nature communications, 7, 13636-13636 (2016-11-29)
Heritable nephrogenic diabetes insipidus (NDI) is characterized by defective urine concentration mechanisms in the kidney, which are mainly caused by loss-of-function mutations in the vasopressin type 2 receptor. For the treatment of heritable NDI, novel strategies that bypass the defective
K K Piotrowska-Tomala et al.
Theriogenology, 153, 1-8 (2020-05-18)
Prostaglandins (PGs) play crucial roles in the regulation of the oestrus cycle and establishment of pregnancy in animals. Luteinizing hormone (LH) and ovarian steroids are involved in regulating endometrial PG production in many species. Their effects on PG production and
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