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Xiao Liu et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(9), 2391-2402 (2014-05-20)
To examine the impact of the gp130 cytokine family on murine articular cartilage and to explore a potential regulatory role of suppressor of cytokine signaling 3 (SOCS-3) in murine chondrocytes. In wild-type (WT) mouse chondrocytes, baseline receptor expression levels and
Karoline St-Martin Crites et al.
Journal of inflammation (London, England), 12, 62-62 (2015-11-10)
Hyperinflammation is a hallmark feature of cystic fibrosis (CF) airways. However, inflammation has also been documented systemically and, more recently, in extrapulmonary CF-affected tissues such as the pancreas and intestine. The pathogenesis of CF-related inflammation and more specifically the role
Carla Russo et al.
Journal of ethnopharmacology, 268, 113614-113614 (2020-11-28)
Salvia officinalis L. (sage), and Chamaemelum nobile (L.) (chamomile) have been used traditionally to treat various inflammatory conditions. Our study aims to investigate the anti-inflammatory properties of both plant extracts in IL-1β-stimulated neuroblastoma cells (SK-N-SH) and human subcutaneous mature adipocytes
James Shue-Min Yeh et al.
PloS one, 10(7), e0129681-e0129681 (2015-07-15)
Microbubbles conjugated with targeting ligands are used as contrast agents for ultrasound molecular imaging. However, they often contain immunogenic (strept)avidin, which impedes application in humans. Although targeting bubbles not employing the biotin-(strept)avidin conjugation chemistry have been explored, only a few
Nada Alaaeddine et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 64(9), 721-731 (2015-07-21)
Local inflammation plays a role in the pathophysiology of osteoarthritis (OA) and chemokines exert catabolic effects on articular cartilage either through paracrine and/or autocrine mechanisms. We sought to compare the expression levels of the chemokine (C-C motif) ligand 20 (CCL20)
Xiaohui Guo et al.
Bioscience reports, 40(7) (2020-07-23)
The purpose of the present study was to investigate the specific downstream signaling pathway mediated by PI3K/Akt in resveratrol (RES) anti-apoptosis of nucleus pulposus cells (NPCs). Human NPCs were cultured and divided into six groups. Interleukin (IL)-1β was used to
Xiaoqiang Su et al.
Journal of cellular biochemistry, 120(8), 13302-13309 (2019-03-21)
Inflammation has been demonstrated to be the key factor for intervertebral disc degeneration (IVD), which remains a major public health problem. Isofraxidin is a coumarin compound that possesses strong anti-inflammatory activity. However, the role of isofraxidin in IVD remains unclear.
Y Sangeeta Devi et al.
PloS one, 10(5), e0125627-e0125627 (2015-05-12)
IL-6 is a multifunctional pro-inflammatory cytokine and has been implicated in many gestational disorders including preterm birth. Currently, there are no appropriate therapeutic interventions available to circumvent inflammatory-mediated gestational disorders. Therefore, the goal of this study was to identify a
Pei-Pei Guan et al.
Oncotarget, 6(11), 9140-9159 (2015-04-01)
Interstitial fluid flow and associated shear stress are relevant mechanical signals in cartilage and bone (patho)physiology. However, their effects on chondrosarcoma cell motility, invasion and metastasis have yet to be delineated. Using human SW1353, HS.819.T and CH2879 chondrosarcoma cell lines
Olga S Safronova et al.
Nucleic acids research, 42(14), 8954-8969 (2014-07-25)
Hypoxia is associated with a variety of physiological and pathological conditions and elicits specific transcriptional responses. The elongation competence of RNA Polymerase II is regulated by the positive transcription elongation factor b (P-TEFb)-dependent phosphorylation of Ser2 residues on its C-terminal
Chia-Huei Lee et al.
Oncotarget, 6(36), 38866-38880 (2015-10-16)
Hyperactivation of the epidermal growth factor receptor (EGFR) pathways and chronic inflammation are common characteristics of oral squamous cell carcinoma (OSCC). Previously, we reported that OSCC cells secrete interleukin-1 beta (IL-1β), which promotes the proliferation of the oral premalignant cell
Anna Santoro et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(12), 1784-1788 (2015-05-29)
Nitric oxide (NO) has been considered a catabolic factor that contributes to OA pathology by inducing chondrocytes apoptosis, matrix metalloproteinases synthesis, and pro-inflammatory cytokines expression. Thus, the research on NO regulation in chondrocytes represents a relevant field which needs to
Tsukasa Nozu et al.
Journal of gastroenterology, 50(12), 1153-1161 (2015-03-27)
Most studies evaluating visceral sensation measure visceromotor response (VMR) to colorectal distention (CRD). However, CRD itself induces visceral sensitization, and little is known about the detailed characteristics of this response. The present study tried to clarify this question. VMR was
Aynur Altuntas et al.
Molecular medicine reports, 12(1), 595-600 (2015-03-12)
Nuclear factor-κB (NF-κB) is involved in the regulation of inflammation‑associated genes. NF-κB forms dimers which bind with sequences referred to as NF-κB sites (9-11 bp). A disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 (ADAMTS9) is a type of
Yasunori Iwabuchi et al.
Journal of oral & facial pain and headache, 28(3), 261-268 (2014-07-30)
To determine the effect of low-intensity pulsed ultrasound (LIPUS) on cyclooxygenase-2 (COX-2) expression and related mechanisms by using cultured articular chondrocytes derived from porcine mandibular condyles after treatment with interleukin-1 beta (IL-1β). Chondrocytes were derived from porcine mandibular condylar cartilage
Maria Gschwandtner et al.
The Journal of investigative dermatology, 134(8), 2192-2201 (2014-04-04)
Antimicrobial peptides (AMPs), an important part of the innate immune system, are crucial for defense against invading microorganisms. Whereas AMPs have been extensively studied in adult skin, little is known about the impact of AMPs in the developing human skin.
Liu Liu et al.
Stem cells international, 2020, 2803747-2803747 (2020-05-08)
Adipose-derived mesenchymal stem cells (ADMSCs) have been used for treating tissue injury, and preactivation enhances their therapeutic effect. This study is aimed at investigating the therapeutic effect of activated ADMSCs by IL-1β on the intestinal ischaemia-reperfusion (IR) injury and exploring
Proinflammatory cytokine IL-1 beta promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: in vivo analysis of tumor-stromal interaction.
Saijo Y
Journal of Immunology, 169, 469-475 (2002)
Jessica Feldt et al.
Osteoarthritis and cartilage open, 2(4), 100124-100124 (2020-11-18)
It is known that recombinant human gelsolin (rhuGSN) supports wound closure and migration processes in avascular tissue. Since articular cartilage degradation plays an important role in osteoarthritis (OA), we are investigating how rhuGSN affects regeneration processes in human articular cartilage
Keguo Jiang et al.
Journal of cell communication and signaling, 15(3), 393-403 (2021-05-05)
Renal tubular epithelial-myofibroblast transdifferentiation (EMT) plays a central role in the development of renal interstitial fibrosis (RIF). The profibrotic cytokine interleukin (IL)-1 and the IL-1 receptor (IL-1R) also participate in RIF development, and Toll/IL-1R 8 (TIR8), a member of the
Yuan Li et al.
Biomedical reports, 15(4), 81-81 (2021-08-26)
Rheumatoid arthritis (RA), a chronic inflammatory synovitis systemic disease, can lead to joint deformities, loss of function and even death. The pathogenesis of RA may be related to genetics, infection and/or sex hormones; however, detailed accounts of the molecular mechanisms
A Adoungotchodo et al.
European cells & materials, 41, 471-484 (2021-05-05)
Injectable therapies for intervertebral disc (IVD) repair are gaining much interest. Recently, a chitosan (CH)-based injectable scaffold has been developed that has similar mechanical properties to human nucleus pulposus (NP) and provides a suitable environment for encapsulated NP cell survival
Xiaoqiang Su et al.
Journal of cellular biochemistry, 120(8), 13302-13309 (2019-03-21)
Inflammation has been demonstrated to be the key factor for intervertebral disc degeneration (IVD), which remains a major public health problem. Isofraxidin is a coumarin compound that possesses strong anti-inflammatory activity. However, the role of isofraxidin in IVD remains unclear.
Pengfei Hu et al.
International journal of clinical and experimental pathology, 7(10), 6575-6584 (2014-11-18)
Cordycepin is widely used as for its various pharmacological activities, such as anti-inflammation, anti-angiogenesis, anti-aging, anti-tumor and anti-proliferation. However, the precise role of cordycepin on chondrocytes is not clear. In the present study, we examined the inhibitory effects of cordycepin
Sunderajhan Sekar et al.
Nutrition (Burbank, Los Angeles County, Calif.), 54, 144-152 (2018-06-01)
Obesity is a known strong risk factor for the onset of knee osteoarthritis and is often accompanied by dysregulated lipid metabolism with elevated levels of free fatty acids such as saturated fatty acids (SFAs). The purpose of this study was
M Al-Kofahi et al.
British journal of pharmacology, 172(16), 4038-4051 (2015-05-20)
The lymphatic system maintains tissue homeostasis by unidirectional lymph flow, maintained by tonic and phasic contractions within subunits, 'lymphangions'. Here we have studied the effects of the inflammatory cytokine IL-1β on tonic contraction of rat mesenteric lymphatic muscle cells (RMLMC).
IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells.
Tsuzaki M
Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society, 21, 256-264 (2003)
Pituitary cytokine and growth factor expression and action.
Ray D and Melmed S
Endocrine Reviews, 18, 206-228 (1997)
Cytokines Regulate ?-Cell Thioredoxin-interacting Protein (TXNIP) via Distinct Mechanisms and Pathways.
Hong K
The Journal of Biological Chemistry, 291, 8428-8439 (2016)
Trevor Starnes et al.
Journal of immunology (Baltimore, Md. : 1950), 169(2), 642-646 (2002-07-05)
A novel cytokine termed IL-17D was cloned using nested RACE PCR. It is a secreted cytokine with homology to the IL-17 family of proteins. IL-17D is preferentially expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas. Treatment of
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