T7750

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Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.

Radika Soysa et al.

The Journal of biological chemistry, 288(41), 29954-29964 (2013-08-30)

The pathogenic protozoan parasite Leishmania donovani is capable of both de novo pyrimidine biosynthesis and salvage of pyrimidines from the host milieu. Genetic analysis has authenticated L. donovani uracil phosphoribosyltransferase (LdUPRT), an enzyme not found in mammalian cells, as the

Oxidation reactions of 2-thiouracil: a theoretical and pulse radiolysis study.

K P Prasanthkumar et al.

The journal of physical chemistry. A, 116(44), 10712-10720 (2012-10-16)

The reaction of hydroxyl radical ((•)OH) with the nucleic acid base analogue 2-thiouracil (1) has been studied by pulse radiolysis experiments and DFT. The generic intermediate radicals feasible for the (•)OH reactions with 1, namely, one electron oxidation product (1(•+))

Intestinal microbiota contribute to the endogenous formation of thiouracil in livestock.

Julie A L Kiebooms et al.

Journal of agricultural and food chemistry, 60(32), 7769-7776 (2012-07-28)

In recent years, the frequent detection of the banned substance thiouracil (TU) in livestock urine has been related to its endogenous formation following consumption of glucosinolate-rich Brassicaceae crops. Besides, TU residues have been recovered in these crops upon plant-derived myrosinase

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Lourdes Santana et al.

Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives

Silver colloid and film substrates in surface-enhanced Raman scattering for 2-thiouracil detection

Al-Shalalfeh MM, et al.

Royal Society of Chemistry Advances, 6, 75282-75292 (2016)

Direct identification of on-bead peptides using surface-enhanced Raman spectroscopic barcoding system for high-throughput bioanalysis.

Homan Kang et al.

Scientific reports, 5, 10144-10144 (2015-05-29)

Recently, preparation and screening of compound libraries remain one of the most challenging tasks in drug discovery, biomarker detection, and biomolecular profiling processes. So far, several distinct encoding/decoding methods such as chemical encoding, graphical encoding, and optical encoding have been

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