T7750

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Synthesis and bioactivity evaluation of new 6-aryl-5-cyano thiouracils as potential antimicrobial and anticancer agents.

Azza Taher Taher et al.

Molecules (Basel, Switzerland), 17(8), 9868-9886 (2012-08-21)

Several novel 6-aryl-5-cyano thiouracil derivatives were synthesized and explored for their activities as antibacterial, antifungal and anticancer agents. The antimicrobial evaluation revealed that compounds 7b and 7c possessed superior antibacterial activity against the Gram positive bacteria S. aureus and B.

Adhesive performance of silver-palladium-copper-gold alloy and component metals bonded with organic sulfur-based priming agents and a tri-n-butylborane initiated luting material.

Miyuki Yamashita et al.

Acta odontologica Scandinavica, 71(1), 196-204 (2012-02-11)

The purpose of the current study was to evaluate the effect of thione-based metal priming agents on the adhesive behavior of a Ag-Pd-Cu-Au alloy and component metals bonded with an acrylic resin. Disk specimens (10 mm in diameter by 3

Novel tryptophan metabolism by a potential gene cluster that is widely distributed among actinomycetes.

Taro Ozaki et al.

The Journal of biological chemistry, 288(14), 9946-9956 (2013-02-23)

The characterization of potential gene clusters is a promising strategy for the identification of novel natural products and the expansion of structural diversity. However, there are often difficulties in identifying potential metabolites because their biosynthetic genes are either silenced or

Potent combination therapy for human breast tumors with high doses of 5-fluorouracil: remission and lack of host toxicity.

Omar N Al Safarjalani et al.

Cancer chemotherapy and pharmacology, 69(6), 1449-1455 (2012-03-01)

The purpose of this investigation was to evaluate the effectiveness of oral 5-(phenylthio)acyclouridine (PTAU) in reducing 5-fluorouracil (FUra) host toxicity and enhancing its chemotherapeutic efficacy against human breast tumors. PTAU is a potent and specific inhibitor of uridine phosphorylase (UP

Solvatochromaticity and pH dependence of the electronic absorption spectra of some purines and pyrimidines and their metal complexes.

Mamdouh S Masoud et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 79(3), 538-547 (2011-05-03)

The solvatochromic responses of uric acid (Ua), 6-amino-2-thiouracil (ATU) and a series of their complexes dissolved in ten solvents of different polarity have been measured. The solvent-dependent UV/Vis spectroscopic absorption maxima, λ(max), are assigned to the corresponding electronic transitions and

Hydration energies of protonated and sodiated thiouracils.

Henryk Wincel

Journal of the American Society for Mass Spectrometry, 25(12), 2134-2142 (2014-10-02)

Hydration reactions of protonated and sodiated thiouracils (2-thiouracil, 6-methyl-2-thiouracil, and 4-thiouracil) generated by electrospray ionization have been studied in a gas phase at 10 mbar using a pulsed ion-beam high-pressure mass spectrometer. The thermochemical data, ΔH(o)n, ΔS(o)n, and ΔG(o)n, for

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