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关键词:'T8158'
显示 1-30 共 122 条结果 关于 "T8158" 范围 论文
Priya Dipta et al.
Comprehensive psychoneuroendocrinology, 7, 100073-100073 (2022-06-28)
Olanzapine and Aripiprazole are widely used second-generation antipsychotic drugs. Olanzapine, more than Aripiprazole, leads to considerable metabolic side effects including obesity and diabetes. While the underlying mechanisms are not fully understood, these side effects are likely associated with mild inflammation
Maike Marczenke et al.
Frontiers in physiology, 8, 469-469 (2017-07-22)
The ultrarapid delayed rectifier K+ current (IKur), mediated by Kv1.5 channels, constitutes a key component of the atrial action potential. Functional mutations in the underlying KCNA5 gene have been shown to cause hereditary forms of atrial fibrillation (AF). Here, we
Erin N Howe et al.
Nature communications, 11(1), 3017-3017 (2020-06-17)
Breast cancer brain metastases (BCBM) have a 5-20 year latency and account for 30% of mortality; however, mechanisms governing adaptation to the brain microenvironment remain poorly defined. We combine time-course RNA-sequencing of BCBM development with a Drosophila melanogaster genetic screen
Aileen F Keating et al.
Toxicology and applied pharmacology, 241(2), 127-134 (2009-08-22)
4-vinylcyclohexene diepoxide (VCD) is an ovotoxicant that specifically destroys primordial and small primary follicles in the ovaries of mice and rats. In contrast, 7,12-dimethylbenz[a]anthracene (DMBA) is ovotoxic to all ovarian follicle classes. This study investigated phosphatidylinositol-3 kinase signaling involvement in
Mohammad Golam Sabbir et al.
Biochimica et biophysica acta. Molecular cell research, 1867(10), 118763-118763 (2020-06-03)
We recently reported that loss of calcium/calmodulin-dependent protein kinase kinase-2 (CAMKK2), a serine/threonine kinase activated by intracellular calcium, in mice leads to tissue-specific aberrant turnover of transferrin (TF), a receptor-mediated iron-transporter that supplies iron to tissues. Iron dyshomeostasis is associated
LncRNA LINC01315 silencing modulates cancer stem cell properties and epithelial-to-mesenchymal transition in colorectal cancer via miR-484/DLK1 axis.
Li, et al.
Cell Cycle, 21, 851-873 (2023)
Minjin Jeong et al.
Communications medicine, 1(1), 44-44 (2021-12-07)
COVID-19 is a pandemic respiratory and vascular disease caused by SARS-CoV-2 virus. There is a growing number of sensory deficits associated with COVID-19 and molecular mechanisms underlying these deficits are incompletely understood. We report a series of ten COVID-19 patients
P S Yoder et al.
Journal of dairy science, 102(10), 8977-8985 (2019-08-20)
Extracellular amino acid profiles affect intracellular AA concentrations and profile as well as signaling proteins that regulate protein translation rates. The objective of this study was to assess whether various extracellular AA profiles and varied ratios of Lys to Met
Anne-Marie Ray et al.
Bioorganic & medicinal chemistry, 40, 116129-116129 (2021-05-11)
Over the past few decades, an increasing variety of molecular chaperones have been investigated for their role in tumorigenesis and as potential chemotherapeutic targets; however, the 60 kDa Heat Shock Protein (HSP60), along with its HSP10 co-chaperone, have received little attention
Jinhua Shen et al.
Methods in molecular biology (Clifton, N.J.), 430, 103-118 (2008-03-29)
In recent years, the field of stem cells has become one of the most rapidly growing areas in biological and medical sciences. Embryonic stem (ES) cells differentiate efficiently in vitro and give rise to many different somatic cell types. The
Liping Hu et al.
PloS one, 15(9), e0238852-e0238852 (2020-09-15)
The pathogenesis of esophageal injury in gastroesophageal reflux disease (GERD) is incompletely understood. We modeled exposure of human esophageal myofibroblasts (HEMFs) to gastroesophageal reflux by repeated treatment with pH 4.5 and pH 4.5 bile salts and determined the effects on
Daniela Fignani et al.
Frontiers in endocrinology, 11, 596898-596898 (2020-12-08)
Increasing evidence demonstrated that the expression of Angiotensin I-Converting Enzyme type 2 (ACE2) is a necessary step for SARS-CoV-2 infection permissiveness. In light of the recent data highlighting an association between COVID-19 and diabetes, a detailed analysis aimed at evaluating
Jin Man Kim et al.
Development (Cambridge, England), 148(6) (2021-03-05)
The actomyosin complex plays crucial roles in various life processes by balancing the forces generated by cellular components. In addition to its physical function, the actomyosin complex participates in mechanotransduction. However, the exact role of actomyosin contractility in force transmission
B Edginton-White et al.
Nature communications, 14(1), 267-267 (2023-01-18)
Developmental control of gene expression critically depends on distal cis-regulatory elements including enhancers which interact with promoters to activate gene expression. To date no global experiments have been conducted that identify their cell type and cell stage-specific activity within one
Zitong Yu et al.
iScience, 25(5), 104200-104200 (2022-04-29)
Organs-on-chips are microfluidic devices for cell culturing to simulate tissue-level or organ-level physiology and recapitulate their microenvironment, providing new and significant solutions other than traditional animal tests. In vitro testing platforms for ocular biological studies have been increasingly used in preclinical
Fang Feng et al.
Frontiers in oncology, 11, 718578-718578 (2021-10-16)
Iodide uptake and the metabolism of thyroid cells are regulated by thyrotropin (TSH)-TSH receptor (TSHR) signaling. Thus, it is necessary to elevate serum TSH levels by T4 withdraw or rTSH administration to facilitate radioiodide (131I) therapy for differentiated thyroid cancer
Sungeun Lee et al.
Biology of reproduction, 103(4), 828-839 (2020-06-25)
Although a few aquaporins (AQPs) expressed in granulosa cells have been postulated to mediate fluid passage into the antrum, the specific expression of AQPs in different follicle cell types and stages and their roles have not been evaluated extensively. The
Yu Yamanoi et al.
Communications biology, 6(1), 88-88 (2023-01-24)
Transient receptor potential vanilloid 3 (TRPV3) belongs to the TRP ion channel super family and functions as a nonselective cation channel that is highly permeable to calcium. This channel is strongly expressed in skin keratinocytes and is involved in warmth
Mingzhi Luo et al.
Biological & pharmaceutical bulletin, 43(7), 1027-1034 (2020-05-15)
Excessive contraction of airway smooth muscle cells (ASMCs) is a hallmark feature of asthma. Intriguing, the activation of bitter taste receptor (TAS2R) in ASMCs can relax ASMCs. However, there is a lack of potent TAS2R agonists that can be used
Pradnya Gangatirkar et al.
Nature protocols, 2(1), 178-186 (2007-04-03)
This protocol describes an ex vivo three-dimensional coculture system optimized to study the skin regenerative ability of primary human keratinocytes grown at the air-liquid interface on collagen matrices embedded with human dermal fibroblasts. An option for enrichment of keratinocyte stem
Shuiqi Li et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37(7), e23031-e23031 (2023-06-21)
It has been demonstrated that hair follicle stem cells (HFSCs) can contribute to wound closure and repair. However, the specific mechanism remains unclear due to the complexity of the wound repair process. Lysine-specific demethylase 1 (LSD1), an important gene for
Zhiwei Qiu et al.
Antioxidants (Basel, Switzerland), 11(1) (2022-01-22)
Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disease characterized by progressive enlargement of fluid-filled cysts derived from renal tubular epithelial cells, which has become the fourth leading cause of end-stage renal diseases. Currently, treatment options for ADPKD
Paola Benaglio et al.
Cell genomics, 2(12), 100214-100214 (2023-02-14)
We combined functional genomics and human genetics to investigate processes that affect type 1 diabetes (T1D) risk by mediating beta cell survival in response to proinflammatory cytokines. We mapped 38,931 cytokine-responsive candidate cis-regulatory elements (cCREs) in beta cells using ATAC-seq
Alexander E Davies et al.
Cell systems, 11(2), 161-175 (2020-07-30)
Intratumoral heterogeneity is associated with aggressive tumor behavior, therapy resistance, and poor patient outcomes. Such heterogeneity is thought to be dynamic, shifting over periods of minutes to hours in response to signaling inputs from the tumor microenvironment. However, models of
Androgen receptor signaling regulates follicular growth and steroidogenesis in interaction with gonadotropins in the ovary during mini-puberty in mice.
Devillers, et al.
Frontiers in Endocrinology, 14, 1130681-1130681 (2023)
Chengyin Min et al.
PloS one, 12(1), e0169128-e0169128 (2017-01-07)
Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic stem cell disorders characterized by defects in myeloid differentiation and increased proliferation of neoplastic hematopoietic precursor cells. Outcomes for patients with AML remain poor, highlighting the need for novel treatment
Esben Pedersen et al.
Methods in molecular biology (Clifton, N.J.), 827, 157-166 (2011-12-07)
Primary keratinocytes are an important tool to investigate the molecular mechanism underlying the skin phenotype of mice with null mutations in Rho GTPase genes. If the RhoA gene deletion is conditional, the knockout can be induced in vitro by transfection
Daniela Malan et al.
Basic research in cardiology, 111(2), 14-14 (2016-01-25)
Long QT syndrome is a potentially life-threatening disease characterized by delayed repolarization of cardiomyocytes, QT interval prolongation in the electrocardiogram, and a high risk for sudden cardiac death caused by ventricular arrhythmia. The genetic type 3 of this syndrome (LQT3)
Paola Romina Amable et al.
PloS one, 9(8), e104662-e104662 (2014-08-15)
Platelet-rich plasma (PRP) is increasingly used as a cell culture supplement, in order to reduce the contact of human cells with animal-derived products during in vitro expansion. The effect of supplementation changes on cell growth and protein production is not
Manabu Sakai et al.
Current protocols, 2(9), e543-e543 (2022-09-08)
The salivary glands produce saliva and are important in maintaining oral health. Saliva keeps the mouth moist, cleanses the oral cavity, aids digestion, and has antibacterial properties. Saliva also helps in swallowing and speech. Investigating the development of the salivary
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