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Henning Willers et al.
Journal of biomedicine & biotechnology, 2008, 821529-821529 (2008-05-17)
Genetic or epigenetic inactivation of the pathway formed by the Fanconi anemia (FA) and BRCA1 proteins occurs in several cancer types, making the affected tumors potentially hypersensitive to DNA cross-linkers and other chemotherapeutic agents. It has been proposed that the
Chia-Yuan Liu et al.
Radiation oncology (London, England), 6, 56-56 (2011-06-01)
This work aimed to investigate the effect of costunolide, a sesquiterpene lactone isolated from Michelia compressa, on cell cycle distribution and radiosensitivity of human hepatocellular carcinoma (HCC) cells. The assessment used in this study included: cell viability assay, cell cycle
Baowei Zhao et al.
Water science and technology : a journal of the International Association on Water Pollution Research, 67(10), 2154-2159 (2013-05-17)
The performance of copper ion removal using sodium dodecyl sulfate (SDS) and its mixtures with Brij 35, Tween 80 (TW80) and Triton X-100 (TX100) by micellar-enhanced ultrafiltration (MEUF) was investigated. The effects of the molar ratio of nonionic surfactant to
Remedios Castelló-Cros et al.
Methods in molecular biology (Clifton, N.J.), 522, 275-305 (2009-02-28)
It is increasingly recognized that interactions between cancer cells and their surrounding stroma are critical for promoting the growth and invasiveness of tumors. For example, cancer cells alter the topography and molecular composition of stromal extracellular matrix by increasing paracrine
Juan C Calderón et al.
The Journal of physiology, 588(Pt 1), 267-279 (2009-11-04)
Electrically elicited Ca(2+) transients reported with the fast Ca(2+) dye MagFluo-4 AM and myosin heavy chain (MHC) electrophoretic patterns were obtained in intact, enzymatically dissociated fibres from adult mice extensor digitorum longus (EDL) and soleus muscles. Thirty nine fibres (23
Sandesh Regmi et al.
Molecular microbiology, 70(3), 724-745 (2008-09-13)
RACK1 is a WD-repeat protein that forms signal complexes at appropriate locations in the cell. RACK1 homologues are core components of ribosomes from yeast, plants and mammals. In contrast, a cryo-EM analysis of trypanosome ribosomes failed to detect RACK1, thus
Lalji K Gediya et al.
Bioorganic & medicinal chemistry, 16(6), 3352-3360 (2008-01-02)
We have developed new, simple, and efficient procedures for the synthesis of two promising histone deacetylase inhibitors (HDIs), CI-994, (N-(2-aminophenyl)-4-acetylaminobenzamide), and MS-275 (N-(2-aminophenyl)4-[N-(pyridine-3-yl-methoxycarbonyl)aminomethyl]benzamide) from commercially available acetamidobenzoic acid and 3-(hydroxymethyl)pyridine, respectively. The procedures provide CI-994 and MS-275 in 80% and
Yuan Lyu et al.
Cells, 9(10) (2020-10-11)
Blood extracellular vesicles (BEVs) carry bioactive cargo (proteins, genetic materials, lipids, licit, and illicit drugs) that regulate diverse functions in target cells. The cannabinoid drug delta-9-tetrahydrocannabinol (THC) is FDA approved for the treatment of anorexia and weight loss in people
Somayeh Karimzadeh et al.
European journal of cell biology, 97(2), 126-135 (2018-02-06)
Recent evidence suggests that mitochondrial apoptosis regulators and executioners may regulate differentiation, without being involved in cell death. However, the involved factors and their roles in differentiation and apoptosis are still not fully determined. In the present study, we compared
A Urbański et al.
Developmental and comparative immunology, 120, 104065-104065 (2021-03-12)
Tachykinin-related peptides (TRPs) are important neuropeptides. Here we show that they affect the insect immune system, especially the cellular response. We also identify and predict the sequence and structure of the tachykinin-related peptide receptor (TRPR) and confirm the presence of
Hadi Shafiee et al.
Scientific reports, 5, 9919-9919 (2015-06-06)
We report a biosensing platform for viral load measurement through electrical sensing of viruses on a flexible plastic microchip with printed electrodes. Point-of-care (POC) viral load measurement is of paramount importance with significant impact on a broad range of applications
Jana L Phan et al.
Journal of experimental botany, 67(22), 6481-6495 (2016-11-20)
Xylans are the most abundant non-cellulosic polysaccharide found in plant cell walls. A diverse range of xylan structures influence tissue function during growth and development. Despite the abundance of xylans in nature, details of the genes and biochemical pathways controlling
Karen M Lammers et al.
Gastroenterology, 135(1), 194-204 (2008-05-20)
Celiac disease is an immune-mediated enteropathy triggered by gliadin, a component of the grain protein gluten. Gliadin induces an MyD88-dependent zonulin release that leads to increased intestinal permeability, a postulated early element in the pathogenesis of celiac disease. We aimed
Lígia Sousa-Ferreira et al.
PloS one, 6(5), e19745-e19745 (2011-05-19)
Some pathological conditions with feeding pattern alterations, including obesity and Huntington disease (HD) are associated with hypothalamic dysfunction and neuronal cell death. Additionally, the hypothalamus is a neurogenic region with the constitutive capacity to generate new cells of neuronal lineage
Yung-Hsin Cheng et al.
Experimental eye research, 179, 179-187 (2018-11-25)
Elevated intraocular pressure (IOP) in glaucoma is due to impairment of aqueous humor drainage via the uveoscleral or trabecular outflow pathway. Latanoprost reduces IOP by increasing the uveoscleral outflow. Despite its potency, long-term daily application of it may cause undesirable
Alireza Pouya et al.
PloS one, 6(11), e27925-e27925 (2011-11-30)
This study aims to differentiate human induced pluripotent stem cells (hiPSCs) into oligodendrocyte precursors and assess their recovery potential in a demyelinated optic chiasm model in rats. We generated a cell population of oligodendrocyte progenitors from hiPSCs by using embryoid
Arkadiusz Urbański et al.
Micron (Oxford, England : 1993), 104, 8-20 (2017-10-20)
The evolutionary success of insects is undoubtedly related to a well-functioning immune system. This is especially apparent during insect development by the adaptation of individuals to the changing risk of infection. In addition, current studies show that the insect immune
C Chan et al.
Electrophoresis, 20(17), 3467-3471 (1999-12-23)
An optimised protocol for the production of two-dimensional protein patterns of human colonic mucosal cells using immobilised pH gradients in the first dimension is presented. We tested a wide variety of solubilising agents and electrophoretic parameters, separately and in combination.
Eveline A C Goossens et al.
International journal of molecular sciences, 21(10) (2020-05-21)
Myostatin is a negative regulator of muscle cell growth and proliferation. Furthermore, myostatin directly affects the expression of 14q32 microRNAs by binding the 14q32 locus. Direct inhibition of 14q32 microRNA miR-495-3p decreased postinterventional restenosis via inhibition of both vascular smooth
Rachel Lopez et al.
Function (Oxford, England), 1(2), zqaa018-zqaa018 (2020-10-20)
Cardiac mechanical function is supported by ATP hydrolysis, which provides the chemical-free energy to drive the molecular processes underlying cardiac pumping. Physiological rates of myocardial ATP consumption require the heart to resynthesize its entire ATP pool several times per minute.
Jun Fujita et al.
Cell stem cell, 2(6), 595-601 (2008-06-05)
Embryonic stem cells (ESCs) are capable of indefinite self-renewal while retaining the ability to differentiate to any of the three germ layers that give rise to all somatic cell types. An emerging view is that a core set of transcription
Margery G H Pelletier et al.
Methods (San Diego, Calif.), 112, 124-146 (2016-09-25)
Neutrophils and macrophages differentiate from common myeloid progenitors in the bone marrow, where they undergo nuclear morphologic changes during maturation. During this process, both cell types acquire critical innate immune functions that include phagocytosis of pathogens, and for neutrophils the
Randall J Brezski et al.
mAbs, 3(6), 558-567 (2011-11-30)
The mammalian antibody repertoire comprises immunoglobulin (Ig) molecules of multiple isotypes and subclasses with varying functional properties. Among the four subclasses of the human IgG isotype, we found that IgG2 exhibits a particular resistance to human and bacterial proteases that
Jin Qian et al.
International journal of molecular sciences, 22(7) (2021-04-04)
Extracellular vesicles (EVs) have an important role in mediating intercellular signaling in inflammation and affect the kinetics of wound healing, however, an understanding of the mechanisms regulating these responses remains limited. Therefore, we have focused on the use of cutaneous
S Tsutsumi et al.
Oncogene, 27(17), 2478-2487 (2007-10-31)
Heat shock protein 90 (Hsp90) is a molecular chaperone that maintains function of numerous intracellular signaling nodes utilized by cancer cells for proliferation and survival. Hsp90 is also detected on the plasma membrane of tumor cells and its expression has
Marie Billaud et al.
PloS one, 4(7), e6432-e6432 (2009-08-04)
Endothelial control of vascular smooth muscle plays a major role in the resulting vasoreactivity implicated in physiological or pathological circulatory processes. However, a comprehensive understanding of endothelial (EC)/smooth muscle cells (SMC) crosstalk is far from complete. Here, we have examined
Xiuling Xu et al.
Bio-protocol, 4(20) (2014-10-20)
In cigarette smoke-induced and inflammation-associated lung cancer development, cigarette smoke extract (CSE) activates tumor necrosis factor-alpha (TNF-α) secretion from macrophages. TNF-α converting enzyme (TACE), also known as α-Secretase or ADAM17 (A Disintegrin and Metalloprotease), is a member of the ADAM
Monika Pietrzak et al.
Biophysical chemistry, 135(1-3), 69-75 (2008-04-22)
We have investigated the ability of chlorophyllin (CHL) to interact with acridine mutagen ICR-191 (2-methoxy-6-chloro-9-(3-(2-chloroethyl)aminopropylamino)acridine) and also its ability to decrease binding of ICR-191 to DNA in a simple three-component competition system: CHL-ICR-DNA. Our data indicate a strong association of
Rafaela C Sartore et al.
PloS one, 6(6), e20667-e20667 (2011-06-16)
The existence of loss and gain of chromosomes, known as aneuploidy, has been previously described within the central nervous system. During development, at least one-third of neural progenitor cells (NPCs) are aneuploid. Notably, aneuploid NPCs may survive and functionally integrate
Changsoo Lee et al.
mAbs, 9(6), 968-977 (2017-06-24)
As biosimilars enter the market, comparisons of product quality are needed. Manufacturing differences may lead to differences in critical quality attributes, which affect efficacy. Therefore, critical quality attributes (structure and biological activity) of Remicade® and of 2 biosimilar products (Flixabi®/Renflexis®
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