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Sooim Shin et al.
Archives of biochemistry and biophysics, 544, 112-118 (2013-10-23)
MauG contains two c-type hemes with atypical physical and catalytic properties. While most c-type cytochromes function simply as electron transfer mediators, MauG catalyzes the completion of tryptophan tryptophylquinone (TTQ)(1) biosynthesis within a precursor protein of methylamine dehydrogenase. This posttranslational modification
Michael Platten et al.
Cancer research, 72(21), 5435-5440 (2012-10-24)
Tryptophan catabolism in cancer is increasingly being recognized as an important microenvironmental factor that suppresses antitumor immune responses. It has been proposed that the essential amino acid tryptophan is catabolized in the tumor tissue by the rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO)
Hanne Sørup Tastesen et al.
PloS one, 9(11), e112859-e112859 (2014-11-13)
Low-protein and high-protein diets regulate energy metabolism in animals and humans. To evaluate whether different dietary protein sources modulate energy balance when ingested at average levels obesity-prone male C57BL/6J mice were pair-fed high-fat diets (67 energy percent fat, 18 energy
Asta Rós Sigtryggsdóttir et al.
Biochimica et biophysica acta, 1844(4), 705-712 (2014-02-25)
The subtilisin-like serine proteinases, VPR, from a psychrotrophic Vibrio species and aqualysin I (AQUI) from the thermophile Thermus aquaticus, are structural homologues, but differ significantly with respect to stability and catalytic properties. It has been postulated that the higher catalytic
Mohammad Mahdi Moein et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 995-996, 38-45 (2015-05-30)
In the present study, the modification of a polysulfone hollow fiber membrane with in situ molecularly imprinted sol-gel process (as a novel and one-step method) was prepared and investigated. 3-(propylmethacrylate)trimethoxysilane (3PMTMOS) as an inorganic precursor was used for preparation of
Ting-Fang He et al.
Biochemistry, 52(51), 9120-9128 (2013-12-03)
Intraprotein electron transfer (ET) in flavoproteins is important for understanding the correlation of their redox, configuration, and reactivity at the active site. Here, we used oxidized flavodoxin as a model system and report our complete characterization of a photoinduced redox
Elnaz Yaghini et al.
Small (Weinheim an der Bergstrasse, Germany), 10(24), 5106-5115 (2014-08-29)
Photocatalytic generation of reactive oxygen species (ROS) from quantum dots (QDs) has been widely reported yet quantitative studies of ROS formation and their quantum yields are lacking. This study investigates the generation of ROS by water soluble PEGylated CdSe/ZnS QDs
Ramón Menta et al.
Cytotherapy, 16(12), 1679-1691 (2014-09-23)
Mesenchymal stromal cells (MSCs) have immunomodulatory properties that are mediated by cell-to-cell interactions and paracrine effects through soluble factors, among which tryptophan (Trp) conversion into kynurenine (Kyn) through the enzymatic activity of indoleamine 2,3-dioxygenase has been proven to be of
Inhibition of indoleamine 2,3-dioxygenase enhances the T-cell response to influenza virus infection.
Julie M Fox et al.
The Journal of general virology, 94(Pt 7), 1451-1461 (2013-04-13)
Influenza infection induces an increase in the level of indoleamine 2,3-dioxygenase (IDO) activity in the lung parenchyma. IDO is the first and rate-limiting step in the kynurenine pathway where tryptophan is reduced to kynurenine and other metabolites. The depletion of
Zhi Chen et al.
Chirality, 27(9), 650-657 (2015-07-17)
A novel method for chiral separation of flurbiprofen enantiomers was developed using aqueous two-phase extraction (ATPE) coupled with biphasic recognition chiral extraction (BRCE). An aqueous two-phase system (ATPS) was used as an extracting solvent which was composed of ethanol (35.0%
A Grimmett et al.
Veterinary journal (London, England : 1997), 170(1), 24-32 (2005-07-05)
Preparations that contain tryptophan are marketed world wide as calmative agents to treat excitable horses. Tryptophan is the amino acid precursor for serotonin, a neurotransmitter implicated in sedation, inhibition of aggression, fear and stress, in various animal species and humans.
Lyudmila V Ignatova et al.
Microbiological research, 175, 78-83 (2015-04-07)
538 yeast strains were isolated from dark chestnut soil collected from under the plants of the legume family (Fabaceae). The greatest number of microorganisms is found at soil depth 10-20 cm. Among the 538 strains of yeast 77 (14.3%) strains
Nicole Seegers et al.
Journal of biomolecular screening, 19(9), 1266-1274 (2014-05-30)
Indoleamine 2,3-dioxygenase (IDO1) and tryptophan 2,3-dioxygenase (TDO) are two structurally different enzymes that have a different tissue distribution and physiological roles, but both catalyze the conversion of tryptophan to N-formylkynurenine (NFK). IDO1 has been clinically validated as a small-molecule drug
Gokce Nardemir et al.
Toxicology and industrial health, 31(7), 602-613 (2013-03-05)
Now-a-days, there is a big need to reduce genotoxic effects of mutagenic and carcinogenic agents in environment, which are increased by the technological development. Lichens produce a wide variety of unique metabolites due to being in various extreme areas and
Adam Skiredj et al.
Organic letters, 16(19), 4980-4983 (2014-09-16)
Applying a biomimetic approach, the first total synthesis of (±)-tubastrindole B is reported herein. This work features a ring-expansion cascade of a dictazole-type precursor into cycloaplysinopsin-type congeners. Moreover, the isolation of a transient biogenetic intermediate represents a milestone in the
Redesign of MST enzymes to target lyase activity instead promotes mutase and dehydratase activities.
Kathleen M Meneely et al.
Archives of biochemistry and biophysics, 539(1), 70-80 (2013-09-24)
The isochorismate and salicylate synthases are members of the MST family of enzymes. The isochorismate synthases establish an equilibrium for the conversion chorismate to isochorismate and the reverse reaction. The salicylate synthases convert chorismate to salicylate with an isochorismate intermediate;
Jian-Zhuang Tan et al.
Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)
The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:
Sooim Shin et al.
The Biochemical journal, 456(1), 129-137 (2013-09-13)
The dihaem enzyme MauG catalyses a six-electron oxidation required for post-translational modification of preMADH (precursor of methylamine dehydrogenase) to complete the biosynthesis of its TTQ (tryptophan tryptophylquinone) cofactor. Trp93 of MauG is positioned midway between its two haems, and in
Jiansheng Liu et al.
Biomaterials, 74, 64-76 (2015-10-09)
Despite optimal therapeutic regimen with currently available antiepileptic drugs (AEDs), approximately a third of epilepsy patients remain drug refractory. Region-specific overexpression of multidrug efflux transporters at the blood-brain barrier, such as P-glycoprotein (P-gp), might contribute to multidrug resistance (MDR) by
William W Parson
Biochemistry, 53(28), 4503-4509 (2014-06-28)
The 35-residue, C-terminal headpiece subdomain of the protein villin folds to a stable structure on a microsecond time scale and has served as a model system in numerous studies of protein folding. To obtain a convenient spectroscopic probe of the
Anthony Bertucci et al.
Bioorganic & medicinal chemistry, 18(6), 2300-2303 (2010-02-24)
The activity of the coral Stylophora pystillata secretory carbonic anhydrase STPCA has been tested in presence of amino acids and amines. All the investigated compounds showed a positive, activating effect on k(cat) and have been separated in weak (K(A) in
Paul J Kennedy et al.
Psychopharmacology, 232(8), 1357-1371 (2014-10-24)
A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine
Tomohiro Shigemori et al.
Journal of biotechnology, 209, 96-101 (2015-06-19)
Glucagon-like peptide-1 (GLP1) is a 30-amino acid peptide hormone activating the GLP1 receptor (GLP1R), a class B G-protein coupled receptor (GPCR), and is considered to be effective for treating diabetes and other metabolic diseases. Phage display is the first innovative
Annemieke T van der Goot et al.
Trends in molecular medicine, 19(6), 336-344 (2013-04-09)
Aging is an important risk factor for many debilitating diseases, including cancer and neurodegeneration. In model organisms, interfering with metabolic signaling pathways, including the insulin/insulin-like growth factor (IGF) 1 (IIS) and TOR pathways, can protect against age-related pathologies and increase
Yuki Murakami et al.
Mediators of inflammation, 2013, 391984-391984 (2013-03-12)
Indoleamine 2,3-dioxygenase 1 (IDO1), the L-tryptophan-degrading enzyme, plays a key role in the immunomodulatory effects on several types of immune cells. Originally known for its regulatory function during pregnancy and chronic inflammation in tumorigenesis, the activity of IDO1 seems to
Emilien Folzer et al.
Journal of pharmaceutical sciences, 104(9), 2824-2831 (2015-05-27)
Oxidation of methionine and tryptophan are common degradation pathways for monoclonal antibodies and present major analytical challenges in biotechnology. Generally, protein oxidation is detectable in stability and/or stressed samples (e.g., exposed to hydrogen peroxide, UV light, or metal ions). The
Meredith H Wilson et al.
Development (Cambridge, England), 142(1), 218-228 (2014-12-18)
During skeletal muscle development, nuclei move dynamically through myotubes in a microtubule-dependent manner, driven by the microtubule motor protein kinesin-1. Loss of kinesin-1 leads to improperly positioned nuclei in culture and in vivo. Two models have been proposed to explain
Daniela Vullo et al.
Bioorganic & medicinal chemistry letters, 17(15), 4107-4112 (2007-06-02)
An activation study of the human carbonic anhydrase (hCA, EC 4.2.1.1) isozymes VII and XIV using a small library of natural/non-natural amino acids and aromatic/heterocyclic amines is reported. hCA VII was efficiently activated by L-/D-His, dopamine and serotonin (K(A)s of
Dorota Jakubczyk et al.
Natural product reports, 31(10), 1328-1338 (2014-08-29)
The ergots are a structurally diverse group of alkaloids derived from tryptophan and dimethylallyl pyrophosphate (DMAPP) . The potent bioactivity of ergot alkaloids have resulted in their use in many applications throughout human history. In this highlight, we recap some
Eduard Dolusić et al.
Journal of medicinal chemistry, 54(15), 5320-5334 (2011-07-06)
Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO) is an important mechanism of peripheral immune tolerance contributing to tumoral immune resistance. IDO inhibition is thus an active area of research in drug development. Recently, our group has shown that tryptophan 2,3-dioxygenase
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