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显示 1-30 共 2815 条结果 关于 "V900116" 范围 论文
Daniel Moreira-Gonçalves et al.
Basic research in cardiology, 110(6), 57-57 (2015-10-16)
Clinical studies suggest that aerobic exercise can exert beneficial effects in pulmonary arterial hypertension (PAH), but the underlying mechanisms are largely unknown. We compared the impact of early or late aerobic exercise training on right ventricular function, remodeling and survival
Seung Kee Cho et al.
International journal of food microbiology, 170, 61-64 (2013-12-03)
Isomaltooligosaccharides (IMOs) are α-(1→6)-linked oligodextrans that show a prebiotic effect on Bifidobacterium spp. This study sought to improve IMO synthesis during lactate fermentation in kimchi by inoculating the kimchi fermentation mix with a starter and sugars; the psychrotrophic Leuconostoc citreum
F M Stell et al.
Journal of medical entomology, 50(4), 804-815 (2013-08-10)
The primary malaria vector in sub-Saharan Africa, Anopheles gambiae Giles (Diptera: Culicidae), is an anthropophagic and endophilic mosquito targeted for control with insecticides applied to interior resting surfaces and impregnated onto bed net materials. Effective malaria vector management involves monitoring
Golgi-mediated glycosylation determines residency of the T2 RNase Rny1p in Saccharomyces cerevisiae.
Natalia Shcherbik
Traffic (Copenhagen, Denmark), 14(12), 1209-1227 (2013-10-10)
The role of glycosylation in the function of the T2 family of RNases is not well understood. In this work, we examined how glycosylation affects the progression of the T2 RNase Rny1p through the secretory pathway in Saccharomyces cerevisiae. We
Sebastian Koob et al.
Biochimica et biophysica acta, 1853(7), 1551-1563 (2015-03-15)
Mitochondrial membrane architecture is important for organelle function. Alterations thereof are linked to a number of human disorders including diabetes and cardiomyopathy. The MICOS complex was recently reported to be a central player determining cristae structure and formation of crista
Vincent Pertici et al.
Biomaterials, 35(24), 6248-6258 (2014-05-13)
The present study is designed to assess the properties of a new degradable PLA-b-PHEMA block copolymer hydrogel and its therapeutic effectiveness after implantation following a thoracic spinal cord hemisection on rats. Degradable characteristics and porous aspect of the scaffold are
Robin M Skory et al.
Human reproduction (Oxford, England), 30(6), 1386-1395 (2015-03-19)
Can cultured follicles model the ovarian cycle, including follicular- and luteal-phase hormone synthesis patterns and ovulation? Under gonadotrophin stimulation, murine follicles grown in an encapsulated three-dimensional system ovulate in vitro and murine and human follicle hormone synthesis mimics follicular and
Ryoko Otsuka et al.
Microbiology and immunology, 59(1), 28-36 (2014-11-21)
Water-insoluble glucan (WIG) produced by mutans streptococci, an important cariogenic pathogen, plays an important role in the formation of dental biofilm and adhesion of biofilm to tooth surfaces. Glucanohydrolases, such as mutanase (α-1,3-glucanase) and dextranase (α-1,6-glucanase), are able to hydrolyze
John H Slater et al.
ACS nano, 9(6), 6128-6138 (2015-05-20)
Heterogeneity of cell populations can confound population-averaged measurements and obscure important findings or foster inaccurate conclusions. The ability to generate a homogeneous cell population, at least with respect to a chosen trait, could significantly aid basic biological research and development
Zhimin Gu et al.
Cancer research, 75(11), 2211-2221 (2015-04-10)
Iron homeostasis is disrupted in multiple myeloma, a difficult-to-cure plasma cell malignancy with lytic bone lesions. Here, we systematically analyzed iron gene expression signature and demonstrated that mRNA expression of iron exporter ferroportin (FPN1) is significantly downregulated in myeloma cells
Signaling role of sucrose metabolism in development.
Yong-Ling Ruan
Molecular plant, 5(4), 763-765 (2012-04-26)
Monica Cojoc et al.
Cancer research, 75(7), 1482-1494 (2015-02-12)
Radiotherapy is a curative treatment option in prostate cancer. Nevertheless, patients with high-risk prostate cancer are prone to relapse. Identification of the predictive biomarkers and molecular mechanisms of radioresistance bears promise to improve cancer therapies. In this study, we show
Jian Han et al.
Microbiology (Reading, England), 161(Pt 1), 57-66 (2014-11-02)
Staphylococcus aureus is a prominent human pathogen and is known to form L-forms in vitro and in vivo during infection. However, the conditions of L-form formation are not optimal and the mechanisms of L-form formation in this organism are unknown.
Tara M Stanne et al.
The Journal of biological chemistry, 290(45), 26954-26967 (2015-09-18)
ISWI chromatin remodelers are highly conserved in eukaryotes and are important for the assembly and spacing of nucleosomes, thereby controlling transcription initiation and elongation. ISWI is typically associated with different subunits, forming specialized complexes with discrete functions. In the unicellular
Qing Li et al.
Cell & bioscience, 5, 45-45 (2015-08-22)
Acute kidney injury (AKI) is a severe disease with high morbidity and mortality. Methods that promote repair of the injured kidney have been extensively investigated. Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney
Sevgi Turker et al.
Biochimica et biophysica acta, 1838(12), 3088-3096 (2014-09-10)
Epilepsy is characterized by disruption of balance between cerebral excitation and inhibition, leading to recurrent and unprovoked convulsions. Studies are still underway to understand mechanisms lying epileptic seizures with the aim of improving treatment strategies. In this context, the research
Yassine Chtourou et al.
Pharmacological reports : PR, 67(6), 1090-1097 (2015-10-21)
In earlier studies, the supplementation of the natural compound Naringenin (NGEN), improved the liver oxidative and inflammatory status, which indicates its direct effect via inhibition of the nuclear factor κB pathway on high cholesterol-induced hepatic damages. In this regard, the
Brett L Jennings et al.
American journal of physiology. Renal physiology, 308(9), F981-F992 (2015-02-20)
Recently, we demonstrated in female mice that protection against ANG II-induced hypertension and associated cardiovascular changes depend on cytochrome P-450 (CYP)1B1. The present study was conducted to determine if Cyp1b1 gene disruption ameliorates renal dysfunction and organ damage associated with
Yasuo Uchida et al.
Drug metabolism and pharmacokinetics, 30(2), 205-208 (2015-03-15)
The purpose of the present study was to evaluate and compare the absolute protein expression levels of 28 drug-related transporters in Caco-2 cell monolayers cultured for 2, 3, and 4 weeks. Plasma membrane fractions of Caco-2 cells cultured on Transwell
Maria M Szwarc et al.
PloS one, 10(6), e0128467-e0128467 (2015-06-11)
Unlike cancers of related exocrine tissues such as the mammary and prostate gland, diagnosis and treatment of aggressive salivary gland malignancies have not markedly advanced in decades. Effective clinical management of malignant salivary gland cancers is undercut by our limited
Aleksandra Milewska et al.
Journal of virology, 88(22), 13221-13230 (2014-09-05)
Human coronavirus NL63 (HCoV-NL63) is an alphacoronavirus that was first identified in 2004 in the nasopharyngeal aspirate from a 7-month-old patient with a respiratory tract infection. Previous studies showed that HCoV-NL63 and the genetically distant severe acute respiratory syndrome (SARS)-CoV
Jinbo Song et al.
Journal of economic entomology, 108(4), 1961-1971 (2015-10-16)
Linepithema humile (Mayr), the Argentine ant, is an invasive pest that has spread throughout the United States and is a problem in natural and managed habitats in South Carolina. Foraging patterns and the effectiveness of liquid baits for control of
Lia R Edmunds et al.
PloS one, 10(7), e0134049-e0134049 (2015-08-01)
The c-Myc (Myc) oncoprotein and AMP-activated protein kinase (AMPK) regulate glycolysis and oxidative phosphorylation (Oxphos) although often for different purposes. Because Myc over-expression depletes ATP with the resultant activation of AMPK, we explored the potential co-dependency of and cross-talk between
Megan Melland-Smith et al.
Autophagy, 11(4), 653-669 (2015-04-09)
Bioactive sphingolipids including ceramides are involved in a variety of pathophysiological processes by regulating cell death and survival. The objective of the current study was to examine ceramide metabolism in preeclampsia, a serious disorder of pregnancy characterized by oxidative stress
Antifungal properties of novel N-and α,β-substituted succinimides against dermatophytes
Lopez, S N, et al.
Arzneimittelforschung, 53(04), 280-288 (2003)
Rosa Gómez-Villafuertes et al.
Cell transplantation, 24(8), 1493-1509 (2014-09-10)
Spinal cord injury (SCI) is a major cause of paralysis with no current therapies. Following SCI, large amounts of ATP and other nucleotides are released by the traumatized tissue leading to the activation of purinergic receptors that, in coordination with
Masahiko Terauchi et al.
Macromolecular bioscience, 15(7), 953-964 (2015-03-27)
Although bone morphogenetic protein-2 (BMP-2) has received considerable attention because of its strong osteoinductivity, the clinical application of BMP-2 is limited due to its degradation and deactivation under physiological conditions. Negatively charged heparin is known to form polyelectrolyte complexes with
Xuan Gao et al.
Journal of pharmaceutical sciences, 104(2), 368-377 (2014-09-02)
The long serum half-lives of mAbs are conferred by pH-dependent binding of IgG-Fc to the neonatal Fc receptor (FcRn). The Fc region of human IgG1 has three conserved methionine residues, Met252, Met358, and Met428. Recent studies showed oxidation of these
Chris Edens et al.
Vaccine, 33(37), 4712-4718 (2015-03-17)
Very high vaccination coverage is required to eliminate measles, but achieving high coverage can be constrained by the logistical challenges associated with subcutaneous injection. To simplify the logistics of vaccine delivery, a patch containing micron-scale polymeric needles was formulated to
Peiliang Shi et al.
The Biochemical journal, 468(2), 325-336 (2015-04-01)
Gasdermin A3 (Gsdma3) was originally identified in association with hair-loss phenotype in mouse mutants. Our previous study found that AE mutant mice, with a Y344H substitution at the C-terminal domain of Gsdma3, display inflammation-dependent alopecia and excoriation [Zhou et al.
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