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Varun Kesherwani et al.
Neuroscience letters, 576, 45-50 (2014-06-07)
Fasudil (HA-1077), a specific Rho kinase II (ROCKII) inhibitor, is in clinical trials for recovery from spinal cord injury (SCI). The primary role of Fasudil is in axonal regeneration, as it inhibits ROCKII, the key signaling molecule involved in collapse
Vadde Sudhakar Reddy et al.
IUBMB life, 67(4), 291-299 (2015-04-23)
αB-Crystallin (αBC) is a member of the small heat shock protein family that responds to a variety of stress and prevents the aggregation of partially unfolded proteins. Chronic hyperglycemia created during diabetes results in skeletal muscle atrophy and leads to
Mi-Joung Lee et al.
Lymphatic research and biology, 12(4), 282-288 (2014-11-21)
Taxanes can cause fluid accumulation by increasing extracellular fluid (ECF). Taxane-based regimens are standard of care for early breast cancer, but it is unknown whether they increase the risk of lymphedema. The aim of this study was to describe the
Takashi Miyata et al.
Journal of molecular recognition : JMR, 25(6), 336-343 (2012-05-30)
Tumor-marker-imprinted hydrogels having lectin and antibody molecules as ligands for a tumor-specific marker glycoprotein were strategically prepared by biomolecular imprinting using minute amounts of low-molecular-weight or high-molecular-weight cross-linkers. The tumor-marker-imprinted hydrogels shrank gradually in response to a target glycoprotein, because
G V Vedamurthy et al.
Parasite immunology, 37(11), 568-578 (2015-09-04)
Haemonchus contortus, an economically important blood-sucking parasite of sheep and goats, survives the harsh host gut environment by secreting a number of proteins referred as excretory/secretory (ES) products. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a glycolytic enzyme, is one of the components of
Christopher A Dieni et al.
PeerJ, 2, e558-e558 (2014-09-12)
The wood frog, Rana sylvatica, survives whole-body freezing and thawing each winter. The extensive adaptations required at the biochemical level are facilitated by alterations to signaling pathways, including the insulin/Akt and AMPK pathways. Past studies investigating changing tissue-specific patterns of
Hao Meng et al.
Acta biomaterialia, 17, 160-169 (2015-02-14)
To decouple the extracellular oxidative toxicity of catechol adhesive moiety from its intracellular non-oxidative toxicity, dopamine was chemically bound to a non-degradable polyacrylamide hydrogel through photo-initiated polymerization of dopamine methacrylamide (DMA) with acrylamide monomers. Network-bound dopamine released cytotoxic levels of
Han Gao et al.
Macromolecular rapid communications, 34(1), 63-68 (2012-10-20)
Traditional pH-sensitive hydrogels inevitably suffer strength deterioration while the responsive weak acid or base groups are in the ionized state. In this study, we report on a facile approach to fabricate a novel pH-sensitive high-strength hydrogel from copolymerization of two
Chikkanna K Raghavendra et al.
Steroids, 94, 21-30 (2014-12-24)
Tender cluster beans (CBs; Cyamopsis tetragonoloba) are observed to possess anti-lithogenic potential in experimental mice. Formation of cholesterol gallstones in gallbladder is controlled by procrystallizing and anticrystallizing factors present in bile in addition to supersaturation of cholesterol. This study aimed
Taissia G Popova et al.
Nanomaterials (Basel, Switzerland), 5(1), 298-320 (2015-04-17)
Chemokines (CKs) secreted by the host cells into surrounding tissue establish concentration gradients directing the migration of leukocytes. We propose an
Joshua L Gowin et al.
Drug and alcohol dependence, 152, 93-101 (2015-05-16)
Nearly half of individuals with substance use disorders relapse in the year after treatment. A diagnostic tool to help clinicians make decisions regarding treatment does not exist for psychiatric conditions. Identifying individuals with high risk for relapse to substance use
Yan Huang et al.
Molecules (Basel, Switzerland), 19(10), 16158-16178 (2014-10-11)
This study investigated genome-wide gene expressions and the cardioprotective effects of electro-acupuncture pretreatment at the PC6 Neiguan acupoint on myocardial ischemia reperfusion (I/R) injury. Male SD rats were randomly divided into four groups: sham operation (SO), I/R, electro-acupuncture at the
Ikram Ullah Khan et al.
International journal of pharmaceutics, 493(1-2), 7-15 (2015-06-28)
In this study, we report on a novel method for the synthesis of poly(acrylamide) Trojan microparticles containing ketoprofen loaded poly(ethyl acrylate) or poly(methyl acrylate) nanoparticles. To develop these composite particles, a polymerizable nanoemulsion was used as a template. This nanoemulsion
Cristina Antunes Garagarza et al.
Hemodialysis international. International Symposium on Home Hemodialysis, 19(3), 412-418 (2015-01-07)
Monitoring nutritional parameters is an integral part of hemodialysis (HD) patient treatment program. The purpose of this study was to evaluate the impact of the personalized nutritional counseling (PNC) on calcium-phosphorus metabolism, potassium, albumin, protein intake, interdialytic weight gain (IDWG)
Zeynep Altintas et al.
Biosensors & bioelectronics, 74, 996-1004 (2015-08-13)
Comparative and comprehensive investigations for adenovirus recognition and detection were conducted using plastic and natural antibodies to compare three different strategies. The implementation of molecularly imprinted polymer (MIP) technology for specific and sensitive recognition of viruses with the combination of
Bin Huang et al.
Medical oncology (Northwood, London, England), 32(1), 408-408 (2014-12-10)
The aim of present investigation is to explore the molecular mechanisms of vasculogenic mimicry (VM) induced by hypoxia. Hepatocellular carcinoma cell lines were treated with CoCl2, and the VM-related parameters were assayed by real-time qPCR, Western blotting and immunofluorescence. Matrigel
Christine Chiasson-MacKenzie et al.
The Journal of cell biology, 211(2), 391-405 (2015-10-21)
The proliferation of normal cells is inhibited at confluence, but the molecular basis of this phenomenon, known as contact-dependent inhibition of proliferation, is unclear. We previously identified the neurofibromatosis type 2 (NF2) tumor suppressor Merlin as a critical mediator of
Joshua R Gershlak et al.
Experimental cell research, 330(2), 311-324 (2014-09-16)
We have previously reported a unique response of traction force generation for cells grown on mature cardiac ECM, where traction force was constant over a range of stiffnesses. In this study we sought to further investigate the role of the
Dong An et al.
Carbohydrate polymers, 134, 385-389 (2015-10-03)
Surfactant-free hydroxypropylcellulose (HPC) nanogels were synthesized by using thermo-sensitive HPC as a template to form HPC/PMAA nanoscale complex. The formation mechanism was owing to the interpolymer hydrogen bonding between HPC and PMAA induced phase transition of HPC in aqueous media.
Stephen Quan et al.
Biomacromolecules, 16(7), 1978-1986 (2015-05-23)
In this study, galactose-based nanogels were prepared by reversible addition-fragmentation chain transfer process to facilitate the targeted delivery of iodoazomycin arabinofuranoside (IAZA), a clinical drug for imaging solid hypoxic tumors, and evaluate its role in hypoxia-selective (radio)theranostic (therapy + diagnostic)
Hari B Krishnan et al.
Journal of agricultural and food chemistry, 63(11), 2862-2869 (2015-03-11)
Soybean is an important protein source for both humans and animals. However, soybean proteins are relatively poor in the sulfur-containing amino acids, cysteine and methionine. Improving the content of endogenous proteins rich in sulfur-containing amino acids could enhance the nutritive
Jessica L Terrell et al.
Nature communications, 6, 8500-8500 (2015-10-13)
Advances in nanotechnology have provided unprecedented physical means to sample molecular space. Living cells provide additional capability in that they identify molecules within complex environments and actuate function. We have merged cells with nanotechnology for an integrated molecular processing network.
Lucie Holubova et al.
Carbohydrate polymers, 112, 271-276 (2014-08-19)
Hyaluronic acid (HA) is known to serve as a dynamic mediator intervening in many physiological functions. Its specific effect has been repeatedly confirmed to be strongly influenced by the molecular size of hyaluronan fragments. However common technological approaches of HA
Anping Peng et al.
Scientific reports, 5, 12173-12173 (2015-07-18)
This is the first investigation of the diversity and distribution of 16S rRNA and phenol monooxygenase (PHE) genes in endophytic and rhizosphere bacteria of plants at sites contaminated with different levels of PAHs. Ten PAHs at concentrations from 34.22 to
Yong Cui et al.
Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors, 29(2), 300-311 (2015-01-27)
Nicotine dependence has been suggested to be related to reinforcement sensitivity, which encompasses behavioral predispositions either to avoid aversive (behavioral inhibition) or to approach appetitive (behavioral activation) stimuli. Reinforcement sensitivity may shape motives for nicotine use and offer potential targets
Carrie P Earthman
JPEN. Journal of parenteral and enteral nutrition, 39(7), 787-822 (2015-08-20)
Because of the key role played by the body's lean tissue reserves (of which skeletal muscle is a major component) in the response to injury and illness, its maintenance is of central importance to nutrition status. With the recent development
Mark William Lopes et al.
Neurochemistry international, 87, 22-33 (2015-05-20)
Disturbances in glutamatergic transmission and signaling pathways have been associated with temporal lobe epilepsy (TLE) in humans. However, the profile of these alterations within specific regions of the hippocampus and cerebral cortex has not yet been examined. The pilocarpine model
Nerea Fernández-Iglesias et al.
Nanoscale, 7(34), 14324-14331 (2015-08-06)
Once nanoparticles enter a biological system, it is known that their surface is instantly covered by the biomolecules present with preference to proteins. This protein corona has been a subject of numerous studies in order to reveal its composition. Besides
Mayrut Urióstegui-Acosta et al.
Toxicology and applied pharmacology, 279(3), 391-400 (2014-07-08)
Methamidophos (MET) is a highly toxic organophosphate (OP) pesticide that is widely used in developing countries. MET has male reproductive effects, including decreased fertility. We evaluated MET effects on sperm quality, fertilization and DNA integrity, exploring the sensitivity of different
Paweł Nakielski et al.
PloS one, 10(6), e0129816-e0129816 (2015-06-20)
Recent biomedical hydrogels applications require the development of nanostructures with controlled diameter and adjustable mechanical properties. Here we present a technique for the production of flexible nanofilaments to be used as drug carriers or in microfluidics, with deformability and elasticity
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