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Marcel Winnig et al.
BMC structural biology, 7, 66-66 (2007-10-16)
Differences in sweet taste perception among species depend on structural variations of the sweet taste receptor. The commercially used isovanillyl sweetener neohesperidin dihydrochalcone activates the human but not the rat sweet receptor TAS1R2+TAS1R3. Analysis of interspecies combinations and chimeras of
R K Sahu et al.
Mutation research, 89(1), 69-74 (1981-05-01)
4 important flavonoid compounds, namely quercetin, kaempferol, neohesperidin dihydrochalcone and rutin, were administered to male mice for the detection of gross chromosomal anomalies by the micronucleus test. The first 3 compounds were positively clastogenic to different extents, whereas the 4th
J H Kroeze
Chemical senses, 25(5), 555-559 (2000-10-04)
Neohesperidin dihydrochalcone (NHDC) is an intensive sweetener, obtained by alkaline hydrogenation of neohesperidin. In this investigation a supposed taste enhancing effect of this substance was tested. A three-step procedure was used. In the first experiment, using a pool of 31
Ahuva Frydman et al.
Journal of agricultural and food chemistry, 53(25), 9708-9712 (2005-12-08)
Neohesperidin dihydrochalcone (NHDC) is a seminatural, safe, low-calorie sweetener, bitterness blocker, and flavor enhancer with unique properties and applications for the food, beverage, pharmaceutical, and animal feed industries. Current production is limited by the availability of the substrate neohesperidin, a
M Naim et al.
Physiology & behavior, 28(6), 979-986 (1982-06-01)
Preference-aversion behavior to solutions containing neohesperidin dihydrochalcone (NHDHC) was studied rats and baboon monkeys. Electrophysiological responses evoked by application of NHDHC solutions to taste receptors innervated by the chorda tympani and the glossopharyngeal nerves were also measured. As a group
Alternative Sweeteners, 87-104 null
An exponential model for adaptation in taste.
J F Gent
Sensory processes, 3(4), 303-316 (1979-12-01)
J S Cho et al.
Journal of agricultural and food chemistry, 48(2), 152-154 (2000-02-26)
Neohesperidin dihydrochalcone (NHDC), a sweet compound derived from citrus fruits, was modified to a series of its oligosaccharides by transglycosylation activity of Bacillus stearothermophilus maltogenic amylase (BSMA). Maltotriose as a donor was reacted with NHDC as an acceptor to glycosylate
D H Waalkens-Berendsen et al.
Regulatory toxicology and pharmacology : RTP, 40(1), 74-79 (2004-07-22)
The embryotoxicity/teratogenicity of neohesperidin dihydrochalcone (NHDC) was examined in Wistar Crl:(WI)WU BR rats. NHDC was fed at dietary concentrations of 0, 1.25, 2.5 or 5 to groups of 28 mated female rats from day 0 to 21 of gestation. At
Lihua Hu et al.
Chemico-biological interactions, 213, 51-59 (2014-02-18)
The purpose of this study was to investigate the possible hepatoprotective effects of neohesperidin dihydrochalcone (NHDC) on carbon tetrachloride (CCl4)-induced acute oxidative injury in vivo and in vitro. In a mouse model, intraperitoneal injection of CCl4 resulted in a significant
Elaheh Kashani-Amin et al.
FEBS letters, 587(6), 652-658 (2013-02-05)
Flavonoids and their precursor trans-chalcone have been reported as inhibitors of mammalian alpha-amylase. With regard to this background, neohesperidin dihydrochalcone (NHDC) effect was investigated toward porcine pancreatic alpha-amylase (PPA), and found to be an activator of the enzyme. The maximal
An estimation of the detection and quantitation limits of neohesperidine DC by high-performance liquid chromatography.
H Montijano et al.
World review of nutrition and dietetics, 85, 125-128 (2000-01-27)
High-potency sweeteners and dental health.
T H Grenby
The Ohio dental journal, 64(2), 15-16 (1990-01-01)
Luciana Malpezzi et al.
Carbohydrate research, 339(12), 2117-2125 (2004-07-29)
The crystal structure of the host-guest noncovalent complex of cyclomaltoheptaose (beta-cyclodextrin, betaCD) with the O-diglycosyl flavonoid neohesperidin dihydrochalcone [(3,5-dihydroxy-4-(3-hydroxy-4-methoxyhydrocinnamoyl)phenyl-2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside, NDC] has been determined from single-crystal X-ray diffraction data collected at low temperature (130 K), using synchrotron radiation. The crystal data
M Nakazato et al.
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan, 42(1), 40-44 (2001-06-01)
An HPLC method was developed for the determination of neohesperidin dihydrochalcone (NHDC) in foods. A solid sample was extracted with methanol. The extract was evaporated and the residue was dissolved in methanol-water (2:8) mixture. In the case of fluid sample
Neohesperidin dihydrochalcone; an updated review on a naturally derived sweetener and flavor potentiator.
Pratter PJ
Perfumer & Flavorist (1980)
Sweeteners--an overview. Part. 1.
J H Shaw
Dental abstracts; a selection of world dental literature, 26(3), 116-120 (1981-03-01)
Meirav Zubare-Samuelov et al.
American journal of physiology. Cell physiology, 285(5), C1255-C1262 (2003-07-04)
The sweeteners saccharin, D-tryptophan, and neohesperidin dihydrochalcone (NHD) and the bitter tastant cyclo(Leu-Trp) stimulated concentration-dependent pigment aggregation in a Xenopus laevis melanophore cell line similar to melatonin. Like melatonin, these tastants inhibited (by 45-92%) cAMP formation in melanophores; pertussis toxin
A Ly et al.
Chemical senses, 26(1), 41-47 (2000-12-22)
The genetically determined ability to taste 6-n-propylthiouracil (PROP) has been linked with lowered acceptance of some bitter foods. Fifty-four women, aged 18-30 years, tasted and rated PROP-impregnated filter paper and seven solutions of PROP. Summed bitterness intensity ratings for PROP
Double functionality of sweeteners: a case of study.
F Borrego et al.
World review of nutrition and dietetics, 85, 39-43 (2000-01-27)
O Benavente-García et al.
Journal of agricultural and food chemistry, 49(1), 189-191 (2001-02-15)
Significant technological advantages in terms of sweetness synergy and hence cost-saving can be obtained if neohesperidin dihydrochalcone (NHDC) is used in sweetener blends with other intense or bulk sweeteners. The combination of NHDC with sodium saccharin or sodium cyclamate is
Je-Min Choi et al.
Biological & pharmaceutical bulletin, 30(2), 324-330 (2007-02-03)
Neohesperidin dihydrochalcone (NHDC), a non-nutritive sweetening agent, is simply produced by hydrogenation of neohesperidin. The aim of this study is to evaluate the antioxidant and radical scavenging properties of neohesperidin dihydrochalcone and other structurally related compounds (phloridzin, neohesperidin) toward different
Andrew W Moran et al.
The British journal of nutrition, 104(5), 637-646 (2010-03-27)
In an intensive livestock production, a shorter suckling period allows more piglets to be born. However, this practice leads to a number of disorders including nutrient malabsorption, resulting in diarrhoea, malnutrition and dehydration. A number of strategies have been proposed
H Montijano et al.
Journal of chromatography. A, 758(1), 163-166 (1997-01-10)
An analytical method to detect and quantitate neohesperidine dihydrochalcone in foodstuffs has been developed and validated in soft-drink applications. The method was shown to be sufficiently precise, accurate, selective and rugged in quantitating neohesperidine DC both at flavouring (1-5 mg/kg)
Annett Braune et al.
Journal of agricultural and food chemistry, 53(5), 1782-1790 (2005-03-03)
The degradation of neohesperidin dihydrochalcone by human intestinal microbiota was studied in vitro. Human fecal slurries converted neohesperidin dihydrochalcone anoxically to 3-(3-hydroxy-4-methoxyphenyl)propionic acid or 3-(3,4-dihydroxyphenyl)propionic acid. Two transient intermediates were identified as hesperetin dihydrochalcone 4'-beta-d-glucoside and hesperetin dihydrochalcone. These metabolites
R L Rouseff
Journal - Association of Official Analytical Chemists, 71(4), 798-802 (1988-07-01)
Naringin/neohesperidin ratios can be used to differentiate orange juice which may contain added grapefruit juice from orange juice which may include juices from other naringin-containing cultivars. The naringin/neohesperidin ratios in juice vary from 14 to 83 in grapefruit (C. grandis)
Paula Arbeláez et al.
Journal of chromatography. A, 1393, 106-114 (2015-04-05)
High-intensity sweeteners have been suggested as potential organic contaminants due to their widespread use in food, drugs and sanitary products. As a consequence, they are introduced into the environment by different pathways, affecting aquatic life. In this study, a method
B A Lina et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 28(7), 507-513 (1990-07-01)
Neohesperidin dihydrochalcone was administered to groups of 20 male and 20 female Wistar rats at dietary levels of 0, 0.2, 1.0 and 5.0% for 91 days. No treatment-related ophthalmoscopical, haematological or histopathological effects were observed. In the high-dose group, a
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