Genetic effects of adiponectin on blood lipids and blood pressure.

Results from the published studies on the association of adiponectin gene (ADIPOQ) polymorphisms with blood lipids and blood pressure are conflicting. We investigated the association of three ADIPOQ polymorphisms, +45 T > G (rs2241766), +276 G > T (rs1501299) and -11377 C > G (rs266729), with these traits in this meta-analysis. We included 35 studies in this meta-analysis. Dominant models were used for this meta-analysis. We did not detect a significant association of the -11377 C > G polymorphism with blood lipids or blood pressure (P > 0·05). The association of the +45 T > G polymorphism with blood lipids and blood pressure was, similarly, not significant (P > 0·05). The meta-analysis suggested a significant overall association of the +276 G > T polymorphism with lower levels of total cholesterol: weighted mean difference (WMD) = -0·10, 95% confidence interval (CI, -0·17, -0·03), P = 0·005, P(heterogeneity)  = 0·04. This association was marginally significant in East Asians and East Asians with type 2 diabetes: WMD = -0·10, 95% CI (-0·20, 0·00), P = 0·05, P(heterogeneity)  = 0·002, and WMD = -0·09, 95% CI (-0·18, -0·00), P = 0·05, P(heterogeneity)  = 0·80, respectively. After exclusion of a study that was the source of heterogeneity, the association was significant in overall populations and marginally significant in East Asians: WMD= -0·06, 95% CI (-0·11, -0·01), P = 0·01, P(heterogeneity)  = 0·98, and WMD = -0·06, 95% CI (-0·12, 0·00), P = 0·07, P(heterogeneity)  = 0·83, respectively. However, none of these associations were significant after Bonferroni correction (significant threshold: P < 0·003). Our meta-analysis does not suggest any association of the three ADIPOQ polymorphisms with blood lipids and blood pressure.