CN
- Mechanism of the regio- and diastereoselective ring expansion reaction using trimethylsilyldiazomethane.
Mechanism of the regio- and diastereoselective ring expansion reaction using trimethylsilyldiazomethane.
Organic letters (2012-08-21)
Takeo Sakai, Satoshi Ito, Hiroki Furuta, Yuki Kawahara, Yuji Mori
PMID22900546
摘要
An equatorial attack of TMS-diazomethane was determined to be the first step of the BF(3)-promoted ring expansion reaction of six-membered ketones using TMS-diazomethane. The migration reaction occurred in a conformation in which the carbonyl oxygen and the TMS group were antiperiplanar to predominantly afford trans-seven-membered ketones.