Genetic variation in LIN28B is associated with the timing of puberty.

Genetic variation in LIN28B is associated with the timing of puberty.

Nature genetics (2009-05-19)

Ken K Ong, Cathy E Elks, Shengxu Li, Jing Hua Zhao, Jian'an Luan, Lars B Andersen, Sheila A Bingham, Soren Brage, George Davey Smith, Ulf Ekelund, Christopher J Gillson, Beate Glaser, Jean Golding, Rebecca Hardy, Kay-Tee Khaw, Diana Kuh, Robert Luben, Michele Marcus, Michael A McGeehin, Andrew R Ness, Kate Northstone, Susan M Ring, Carol Rubin, Matthew A Sims, Kijoung Song, David P Strachan, Peter Vollenweider, Gerard Waeber, Dawn M Waterworth, Andrew Wong, Panagiotis Deloukas, Inês Barroso, Vincent Mooser, Ruth J Loos, Nicholas J Wareham

PMID19448623

摘要

The timing of puberty is highly variable. We carried out a genome-wide association study for age at menarche in 4,714 women and report an association in LIN28B on chromosome 6 (rs314276, minor allele frequency (MAF) = 0.33, P = 1.5 × 10(-8)). In independent replication studies in 16,373 women, each major allele was associated with 0.12 years earlier menarche (95% CI = 0.08-0.16; P = 2.8 × 10(-10); combined P = 3.6 × 10(-16)). This allele was also associated with earlier breast development in girls (P = 0.001; N = 4,271); earlier voice breaking (P = 0.006, N = 1,026) and more advanced pubic hair development in boys (P = 0.01; N = 4,588); a faster tempo of height growth in girls (P = 0.00008; N = 4,271) and boys (P = 0.03; N = 4,588); and shorter adult height in women (P = 3.6 × 10(-7); N = 17,274) and men (P = 0.006; N = 9,840) in keeping with earlier growth cessation. These studies identify variation in LIN28B, a potent and specific regulator of microRNA processing, as the first genetic determinant regulating the timing of human pubertal growth and development.