CN
KCNQ2
potassium voltage-gated channel, KQT-like subfamily, member 2
别名:
BFNC, BFNS1, EBN, EBN1, EIEE7, ENB1, HNSPC, KCNA11, KV7.2, KVEBN1
物种:
Human KCNQ2 (3785), Mouse Kcnq2 (16536), Rat Kcnq2 (170848), chicken KCNQ2 (428151), naked mole-rat Kcnq2 (101715997), domestic guinea pig Kcnq2 (100732168), sheep KCNQ2 (101118630), domestic cat KCNQ2 (101101044), Horse KCNQ2 (100146986), cow KCNQ2 (505963) ...展开
UniProtKB ID:
基因ID:
- Human(3785) Summary: The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(16536) potassium voltage-gated channel, subfamily Q, member 2
- Rat(170848) potassium voltage-gated channel, KQT-like subfamily, member 2
- chicken(428151) potassium voltage-gated channel, KQT-like subfamily, member 2
- naked mole-rat(101715997) potassium voltage-gated channel, KQT-like subfamily, member 2
- domestic guinea pig(100732168) potassium voltage-gated channel, KQT-like subfamily, member 2
- sheep(101118630) potassium voltage-gated channel, KQT-like subfamily, member 2
- domestic cat(101101044) potassium voltage-gated channel, KQT-like subfamily, member 2
- Horse(100146986) potassium voltage-gated channel, KQT-like subfamily, member 2
- cow(505963) potassium voltage-gated channel, KQT-like subfamily, member 2
- dog(612515) potassium voltage-gated channel, KQT-like subfamily, member 2
- Zebrafish(100537363) potassium voltage-gated channel, KQT-like subfamily, member 2
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Small Molecule - Activator
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说明
物种
Antibodies
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说明
物种反应性
应用
Anti-KCNQ2 antibody produced in rabbit, IgG fraction of antiserum,
物种反应性
bovine, dog, guinea pig, horse, human, mouse, rat
应用
immunohistochemistry
western blot
western blot
Anti-KCNQ2 (AB2) antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, dog, guinea pig, horse, human, mouse, rat
应用
immunohistochemistry
western blot
western blot
Anti-KCNQ2 (AB1) antibody produced in rabbit, affinity isolated antibody,
物种反应性
bovine, dog, guinea pig, horse, human, mouse, rat
应用
western blot
Anti-KCNQ2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Small Molecule - Blocker
Small Molecule - Inhibitor
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esiRNA
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物种