G002
异去甲基槟榔次碱 盐酸盐
solid
别名:
1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
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关于此项目
经验公式（希尔记法）:
C6H9NO2 · HCl
CAS Number:
分子量:
163.60
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
质量水平
颜色
white
溶解性
H2O: soluble (refrigerate if not used immediately.)
methanol: slightly soluble
neutral and acidic solutions: stable (in basic solutions the free amine can oxidize easily)
SMILES字符串
Cl[H].OC(=O)C1=CCNCC1
InChI
1S/C6H9NO2.ClH/c8-6(9)5-1-3-7-4-2-5;/h1,7H,2-4H2,(H,8,9);1H
InChI key
SUWREQRNTXCCBL-UHFFFAOYSA-N
基因信息
应用
Isoguvacine hydrochloride has been used as a γ-aminobutyric acid type A (GABAA) receptor agonist:
- to study its effects on neuronal activity in rats
- to study its antiallodynic effect in rats
- to study its effects on baroreflex gains in rats
生化/生理作用
Isoguvacine is a strong γ-aminobutyric acid A (GABAA) receptor agonist.
特点和优势
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
J W Polson et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 293(5), R1954-R1960 (2007-09-07)
Microinjection of angiotensin II into the nucleus tractus solitarii attenuates the baroreceptor reflex-mediated bradycardia by inhibiting both vagal and cardiac sympathetic components. However, it is not known whether the baroreflex modulation of other sympathetic outputs (i.e., noncardiac) also are inhibited
Frederik Rode et al.
European journal of pharmacology, 516(2), 131-138 (2005-06-07)
Gamma aminobutyric acid (GABA) plays a major role in the central hyperexcitabilty associated with nerve damage. The precise antinociceptive actions mediated by GABA(A) receptor agonists remain unclear as previous studies have shown mixed results in neuropathic pain models. Thus, various
Mathias Dutschmann et al.
The European journal of neuroscience, 24(4), 1071-1084 (2006-08-26)
Lesion or pharmacological manipulation of the dorsolateral pons can transform the breathing pattern to apneusis (pathological prolonged inspiration). Apneusis reflects a disturbed inspiratory off-switch mechanism (IOS) leading to a delayed phase transition from inspiration to expiration. Under intact conditions the
Biochemical pharmacology of GABAergic agonists.
S J Enna et al.
Life sciences, 24(19), 1727-1737 (1979-05-07)
Qi-Jian Sun et al.
The Journal of physiology, 589(Pt 7), 1819-1830 (2011-02-16)
A striking effect of stimulating the superior laryngeal nerve (SLN) is its ability to inhibit central inspiratory activity (cause ‘phrenic apnoea'), but the mechanism underlying this inhibition remains unclear. Here we demonstrate, by stimulating the SLN at varying frequencies, that
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