CN
GRM6
glutamate receptor, metabotropic 6
Synonyms:
CSNB1B, GPRC1F, MGLUR6, mGlu6
Species:
Human GRM6 (2916), Mouse Grm6 (108072), Rat Grm6 (24419), domestic guinea pig Grm6 (100722389), naked mole-rat Grm6 (101717017), cow GRM6 (529656), domestic cat GRM6 (101097449), dog GRM6 (481452)
UniProtKB ID:
Gene ID:
- Human(2916) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012]
- Mouse(108072) glutamate receptor, metabotropic 6
- Rat(24419) glutamate receptor, metabotropic 6
- domestic guinea pig(100722389) glutamate receptor, metabotropic 6
- naked mole-rat(101717017) glutamate receptor, metabotropic 6
- cow(529656) glutamate receptor, metabotropic 6
- domestic cat(101097449) glutamate receptor, metabotropic 6
- dog(481452) glutamate receptor, metabotropic 6
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Small Molecule - Agonist
Product Number
Description
Species
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
Small Molecule - Antagonist
Product Number
Description
Species
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Species
rat, human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-GRM6 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
Monoclonal Anti-GRM6 antibody produced in mouse, clone 1A11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-GRM6 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
Anti-MGLUR6 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Metabotropic Glutamate Receptor 6 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunohistochemistry
Small Molecule - Mixed Agonist/Antagonist
Product Number
Description
Species
L-(+)-2-Amino-4-phosphonobutyric acid, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
Species
rat, human
L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
Species
rat, human