With billions of neurons and trillions of synapses, the brain is a complex, intricate network that continues to challenge and fascinate scientists. Delve into the complexities of the brain with Merck. Our Neurobiology Research Portal bridges cutting-edge products and technical expertise with the collective wisdom of the global research community. Together, we're unlocking the secrets of neural networks and advancing the field of neuroscience.
With our focused portfolio, start your neurobiology project with confidence, Here you can access curated technical resources, exclusive webinars, and relevant technical product brochures.
Model
Generation or collection of a biologically relevant model to comprehend the biological system under study, enabling the identification of key components, exploration of underlying mechanisms, and the formation of hypotheses to establish the foundation of the experimental framework, pivotal for advancing neuroscience research.
- Neural Cell Lines
- Primary Cell Culture
- Stem Cells
- Mammalian Cell Lines
- Alzheimer’s In A Dish™: 3D Neural Stem Cell Models of Alzheimer's Disease
- 3D Cell Culture
- 3D Neurosphere Culture Media
- Corning® Spheroid Microplates
- CytoSoft® Elastic Modulus Plates
- Human Oligodendrocyte Differentiation
- Human Neural Stem Cell Characterization
- Neural Stem Cell Marker Characterization
- Human Oligodendrocyte Characterization
- Attachment Factors
- Corning Matrigel® Matrix Products
- Millicell® Inserts and Plates
- Animal Component Free Cell Culture
- Cell Culture Classic Tools & Reagents
Manipulate
Experiments to modify and prepare the sample for specific downstream analysis by leveraging various technologies including cell culture, genetic engineering and molecular/protein biology methods, all tailored to advancing neuroscience research.
- GABAA Receptors
- Bioactive Small Molecules for Neuroscience
- Neuropeptidases
- Neurotensin Receptors
- GABA Transporters
- Growth Factors and Cytokines
- miRNA Mimics
- CRISPR
- shRNA
- siRNA
- esiRNA
- Screening Libraries
- Small Molecules Library Screening LOPAC®1280
- Lipopolysaccharides for Research
- Fibroblast Growth Factor Family (FGF)
Measure
Acquiring quantitative data and analyzing experiment outcomes with various techniques i.e. cell-based readouts, molecular analyses, protein assays, and other relevant measurements, all crucial for research in neuroscience.
- Cell Counting
- Millicell® ERS 3.0 Digital Voltohmmeter
- Duolink® PLA
- Neuroscience Multiplex Assays
- Ultrasensitive Neurology Immunoassays
- Neuroimmunology & Neuroinflammation
- Neuroscience Assay Kits for Metabolite Analysis
- Milli-Mark® FluoroPan Neuronal Marker - 488 conjugated
- High Sensitivity Human Amyloid β40 ELISA
- High Sensitivity Human Amyloid β42 ELISA
- Prestige® Antibodies for Neuroscience
- ZooMAb® Antibodies for Neuroscience
- IHC/ICC
- Protein Electrophoresis & Western Blot
- Amicon® Ultrafiltration Devices
- GenElute™-E DNA & RNA Purification Kits
- Genotyping
- Primers and Probes
- qPCR
Related Articles & Protocols
- Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.
- Step-by-step culture protocols for neural stem cell culture including NSC isolation, expansion, differentiation and characterization.
- Frequently asked questions about neural stem cells including NSC derivation, expansion and differentiation.
Related Product Supporting Articles
- Learn how to integrate multiplex and high sensitivity immunoassay technology to further neuroscience research with MILLIPLEX® multiplex and Single Molecule Counting (SMC®) high sensitivity immunoassay detection of Alzheimer’s disease (AD) biomarkers in human cerebrospinal fluid, plasma, and serum samples.
- Discover how to expand neuroscience biomarker research with high sensitivity immunoassays, such as Single Molecule Counting (SMC®) assays. These assays give researchers the tools they need to detect low-abundant blood-based biomarkers and expand biomarker options in neuroscience research.
- Multiplex detection of Alzheimer's biomarkers with MILLIPLEX® Human Amyloid Beta and Tau Magnetic Bead Panel aids research.
Related Resources
- Brochure: Elevating NeuroBiology Research
Neural Models, Neural Modulation, Biomarker Discovery and Neural Detection Tools
- Application Note: ReNcell® Human Neural Progenitors
Renewable and Consistent Supply of Human Functional Neurons
- Application Note: Next-Level Neuroscience with Single Molecule Counting (SMC®) Technology
Ultrasensitive Single Molecule Counting (SMC®) immunoassay technology enables low-abundant biomarker measurement in a variety of biofluids such as serum, plasma, and CSF.
- Flyer: Most Cited Neuroscience Antibodies
By integrating the antibody expertise and resources of Calbiochem®, Chemicon®, and Upstate®, we are now the most cited provider of neuroscience antibodies.
- Neuroinflammation
Fire up your research with neuroinflammation biomarker immunoassays that will ignite your studies
- Brochure: Prestige Antibodies® in Neuroscience
The human protein atlas.
- Case Study: Sanger Testimonial
Read about how Dr. Emmanouil Metzakopian and his team are successfully using the Sigma-Aldrich® CRISPR product portfolio to prioritize gene targets for drug development to treat neurodegenerative diseases.
- Flyer: New Tools for Synaptic Biomarker Research
Ultrasensitive Single Molecule Counting (SMC®) Human SNAP-25 and TDP-43 Kits
- Poster: Ultrasensitive detection of total and phosphorylated Tau protein in human blood using SMC® technology
Few analytes epitomize the utility of ultrasensitive immunoassays in blood-based biomarker research better than total and phosphorylated Tau protein.
- Poster: Quantitation of neurodegenerative biomarkers in plasma using Single Molecule Counting (SMC®) high sensitivity immunoassays
Quantification of protein biomarkers in patients with Alzheimer’s Disease (AD) and Parkinson’s disease (PD) is important for monitoring neurodegeneration.
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