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Merck
CN

19915

Sigma-Aldrich

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide

≥97.0% (GC)

Synonym(s):

MTBSTFA

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About This Item

Linear Formula:
CF3CON(CH3)Si(CH3)2C(CH3)3
CAS Number:
Molecular Weight:
241.33
Beilstein:
3606546
MDL number:
UNSPSC Code:
12352001
PubChem Substance ID:
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Assay

≥97.0% (GC)

refractive index

n20/D 1.402 (lit.)

bp

172-175 °C (lit.)

density

1.036 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C

InChI

1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

InChI key

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

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Other Notes

Powerful reagent for the introduction of the tert-butyldimethylsilyl group under neutral conditions

Pictograms

Flame

Signal Word

Warning

Hazard Statements

Hazard Classifications

Flam. Liq. 3

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

113.0 °F - closed cup

Flash Point(C)

45 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

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K. Schoene et al.
Fresenius Journal of Analytical Chemistry, 348, 364-364 (1994)
J. Heberle et al.
Silylating Agents, 2nd ed. (1995)
M. Donike et al.
Journal of Chromatography A, 202, 483-483 (1980)
A.C. Bazan, D.R. Knapp
Journal of Chromatography A, 236, 201-201 (1982)
Tian-Xiang Wang et al.
Cell death & disease, 10(10), 755-755 (2019-10-09)
Ferroptosis is a non-apoptotic form of cell death characterized by the iron-dependent lipid peroxidation and is implicated in several human pathologies, such as tissue ischemia, neurodegeneration, and cancer. Ferroptosis appears to be high cell-context dependent and the regulation of ferroptosis

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