Gene therapy manufacturing

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Visit us at booth #7 to learn about our solutions to help you overcome your mRNA manufacturing and LNP formulation challenges.

DCAT Week

If you're planning to attend DCAT Week this year, stop by the Dunhill and Century suites at the Benjamin Royal Sonesta and meet the MilliporeSigma team.

Scalability Challenges of Viral Vector Manufacturing

Scaling up viral vector production using adherent cell culture systems is challenging. Learn how suspension cell culture systems benefit large-scale bioprocessing.

Bioreactor Process Development and Scale-Up for Transient Transfection-Based Lentivirus Manufacturing in Suspension Cell Culture

A step-by-step overview of suspension-based, transient transfection bioreactor process development and scaleup of lentivirus production.

BIO International

We warmly invite you to visit booth 4735 at BIO International and connect with the MilliporeSigma team.

Lentivirus Platform: Optimizing Performance for De-Risked Production

Learn how the VirusExpress® lentivirus platform utilizes DoE experiments and supplementary studies to optimize workflows, enhance yield, and ensure quality in cell and gene therapies.

Rapid Adenovirus Detection: Lot Release

Webinar introduces rapid RCA detection assay combining culture assay with molecular endpoint for replication competent adenovirus.

Gene Therapy: R&D to IND Regulatory Navigation

Advance gene therapy efficiently with insights from experts on implementing a "right first time" testing strategy in limited resources.

NGS Identity Testing for Viral Gene Therapies

Webinar discusses risk mitigation testing strategies for viral vector identity confirmation after unexpected sequence variants.

Holistic Approach to Optimize Viral Vector Harvest

Webinar explores challenges and solutions in viral vector harvest for bioprocessing.

AAV Gene Therapy Potential

Ensure AAV safety in drug development journey, speeding clinic readiness for more effective disease treatment.

Strategies for the Separation and Analysis of Empty and Filled Capsids During Viral Vector Production

Explore strategies for separating empty and filled capsids in viral vector production. Learn about upstream strategies and how trends in AAV capsid design impact purification.

Development and Optimization of a Lentivirus Manufacturing Platform

Learn how development of a suspension adapted HEK293T cell line with accompanying cell culture media can maximize lentivirus production for cell and gene therapies.

Membrane Filtration: Efficient Particle Retention and Bioburden Reduction in Bioprocessing Fluid Streams

Some prefilters reduce bioburden and can be used as a cost-effective alternative to sterilizing filters for bioburden control in bioprocessing.

Viral Vector Characterization & Biosafety

Gene therapy demands biosafety testing for product safety and process understanding before patient use.

Viral Vector Downstream Processing

New gene therapies drive the need for scalable purification technologies in downstream operations for higher yield and throughput.

Bioprocessing And Scale-Up Of Suspension HEK293 Cells For AAV Manufacturing

To address scalability challenges of AAV manufacturing, we developed an HEK293 suspension cell line that can be used across many serotypes. Get the data in this article.

Development of a Novel Sf9 Rhabdovirus-Negative Cell Line (Sf-RVN®) and Companion Chemically Defined Medium

See how the Sf9 rhabdovirus-free cell line was developed and how we’ve developed a companion chemically-defined insect cell media for protein and viral expression.

Promote Optimal Cell Growth with Single-Use Bioprocessing Film

Bioprocessing film designed for cell culture. Switch to Irgafos®168 free bioreactor bags to optimize cell growth and productivity.

Bioprocessing Bag Films: Key Characteristics & Properties

Leak-Proof Bioprocessing Bags. Stronger Films, Better Results, Lower Costs.

Lentivirus Harvest Clarification Process for Cell & Gene

Explore lentivirus harvest clarification options for viral therapy production using suspension cell lines in manufacturing platform development.

Pharma 4.0 Global Bioprocessing

Pharma 4.0 Summit discusses bioprocessing solutions for antibody, vaccine, and gene therapy development.

Viral Vector Formulation, Filtration & Filling

Formulate gene therapies to meet regulatory requirements, optimizing downstream processes for reproducible product quality, safety, yield, and purity.

DNA/RNA Removal in Viral Production

Benzonase®endonuclease efficiently removes nucleic acid contaminants from viral production, crucial for cell and gene therapies and vaccines.

AAV Process Intensification Using High Salt Lysis and Salt Tolerant Endonuclease

This page describes key considerations for cell lysis and how the combination of a high salt concentration and a salt tolerant endonuclease can be used to increase vector titer and infectivity during AAV vector manufacturing.

Gene Therapy Manufacturing

Gene therapy innovation requires integrated manufacturing, testing, safety, and compliance expertise from experienced partners.

Building Regional Cell Culture Media Supply Chains

Ensure reliable cell culture media supply with our continuously expanding global network of regional sites for resilient biopharma manufacturing.