Abstract
The creation of complex systems whether electronic, mechanical, chemical, or biological can prove incredibly challenging. Engineering principles such as abstraction, standardization, and formalism have the ability to make this creation process easier, cheaper, faster, and more efficient. Synthetic Biology, the forward engineering of novel biological systems, is an excellent candidate for these types of approaches. In this talk, I will outline my vision for “Bio-Design Automation” for synthetic biology. Specifically I will highlight my research’s efforts in the specification, design, assembly, verification, and data management involved in automating synthetic biology. These challenges are addressed by a suite of software tools which draw inspiration from Electronic Design Automation. I will highlight a domain specific language for synthetic biology called Eugene, an automated DNA assembly planner called Raven, and a liquid handling scheduling system called Puppeteer. In addition I will discuss logic synthesis techniques for synthetic biology (Cello), hybrid microfluidic bio-computation (Fluigi), and my work with undergraduate outreach through the International Genetically Engineered Machine (iGEM) competition. I will close by discussing community and commercial involvement mechanisms via the Bio-Design Automation Consortium, the Nona Research Foundation, and Lattice Automation, Inc.
Speakers
Douglas Densmore
Boston University
Kern Faculty Fellow
Douglas Densmore is a Kern Faculty Fellow, a Hariri Institute for Computing and Computational Science and Engineering Junior Faculty Fellow, and Associate Professor in the Department of Electrical and Computer Engineering at Boston University. He is the director of the Cross-disciplinary Integration of Design Automation Research (CIDAR) group at Boston University, where his team of staff and postdoctoral researchers, undergraduate interns, and graduate students develop computational and experimental tools for synthetic biology. His research facilities include both a computational workspace in the Department of Electrical and Computer Engineering as well as experimental laboratory space in the Boston University Center of Synthetic Biology (CoSBI).
Research and disease areas
- Cell and developmental biology research
期间:57min
语言:English
场次 1:往期 July 24, 2015
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