FIP1L1
factor interacting with PAPOLA and CPSF1
别名:
FIP1, Rhe, hFip1
物种:
Human FIP1L1 (81608), Mouse Fip1l1 (66899), Rat Fip1l1 (289582), cow FIP1L1 (100138550), sheep FIP1L1 (101115126), Domestic Rabbit FIP1L1 (100341056), dog FIP1L1 (612980), domestic cat FIP1L1 (101092180), Horse FIP1L1 (100060154), naked mole-rat Fip1l1 (101700547) ...展开
UniProtKB ID:
基因ID:
- Human(81608) Summary: This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
- Mouse(66899) FIP1 like 1 (S. cerevisiae)
- Rat(289582) factor interacting with PAPOLA and CPSF1
- cow(100138550) FIP1 like 1 (S. cerevisiae)
- sheep(101115126) FIP1 like 1 (S. cerevisiae)
- Domestic Rabbit(100341056) FIP1 like 1 (S. cerevisiae)
- dog(612980) FIP1 like 1 (S. cerevisiae)
- domestic cat(101092180) FIP1 like 1 (S. cerevisiae)
- Horse(100060154) FIP1 like 1 (S. cerevisiae)
- naked mole-rat(101700547) FIP1 like 1 (S. cerevisiae)
- domestic guinea pig(100725850) factor interacting with PAPOLA and CPSF1
- chicken(422754) FIP1 like 1 (S. cerevisiae)
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Antibodies
产品编号
说明
物种反应性
应用
Anti-FIP1L1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-FIP1L1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
western blot
western blot
Anti-Fip1L1 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence