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Merck
CN

HLA-DRB4

major histocompatibility complex, class II, DR beta 4

别名:
DR-4, DR4, DRB4, HLA-DR4B
物种:
Human HLA-DRB4 (3126)
UniProtKB ID:
P13762, B0S863, O78042, P79664, Q29889, Q30163, Q6TLK6, Q860N4
基因ID:
  • Human(3126) Summary: HLA-DRB4 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB4 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

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Antibodies

Product Number
说明
物种反应性
应用
WH0003126M1
Monoclonal Anti-HLA-DRB4 antibody produced in mouse, clone 4C8, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
western blot
SAB1401180
Anti-HLA-DRB4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot
SAB5701972
Anti-HLA-DRB4 Antibody, clone 3Z5V9, Rabbit Monoclonal, ,
物种反应性
human
应用
western blot
SAB1403921
Monoclonal Anti-HLA-DRB4, (C-terminal) antibody produced in mouse, clone 4C8, ascites fluid,
物种反应性
human
应用
ELISA
western blot

esiRNA

Product Number
说明
物种
EHU231021
MISSION® esiRNA, targeting human HLA-DRB4,
物种
human