MRVI1
murine retrovirus integration site 1 homolog
别名:
IRAG, JAW1L
物种:
Human MRVI1 (10335), Mouse Mrvi1 (17540), Rat Mrvi1 (308899), dog MRVI1 (485389), domestic cat MRVI1 (101088106), Horse MRVI1 (100071324), naked mole-rat Mrvi1 (101708783), sheep MRVI1 (101102086), chicken MRVI1 (423037), cow MRVI1 (281918)
UniProtKB ID:
基因ID:
- Human(10335) Summary: This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]
- Mouse(17540) MRV integration site 1
- Rat(308899) murine retrovirus integration site 1 homolog
- dog(485389) murine retrovirus integration site 1 homolog
- domestic cat(101088106) murine retrovirus integration site 1 homolog
- Horse(100071324) murine retrovirus integration site 1 homolog
- naked mole-rat(101708783) murine retrovirus integration site 1 homolog
- sheep(101102086) murine retrovirus integration site 1 homolog
- chicken(423037) murine retrovirus integration site 1 homolog
- cow(281918) murine retrovirus integration site 1 homolog
- domestic guinea pig(100734048) murine retrovirus integration site 1 homolog
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Antibodies
产品编号
说明
物种反应性
应用
Anti-MRVI1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry