NFASC
neurofascin
别名:
NF, NRCAML
物种:
Human NFASC (23114), Mouse Nfasc (269116), Rat Nfasc (116690), Horse NFASC (100054575), cow NFASC (512796), dog NFASC (488565), domestic cat NFASC (101083317), chicken NFASC (419824), domestic guinea pig Nfasc (100721545), naked mole-rat Nfasc (101716337)
UniProtKB ID:
基因ID:
- Human(23114) Summary: This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
- Mouse(269116) neurofascin
- Rat(116690) neurofascin
- Horse(100054575) neurofascin
- cow(512796) neurofascin
- dog(488565) neurofascin
- domestic cat(101083317) neurofascin
- chicken(419824) neurofascin
- domestic guinea pig(100721545) neurofascin
- naked mole-rat(101716337) neurofascin
- sheep(101109290) neurofascin
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