RASA1
RAS p21 protein activator (GTPase activating protein) 1
别名:
CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP
物种:
Human RASA1 (5921), Mouse Rasa1 (218397), Rat Rasa1 (25676), domestic cat RASA1 (101095151), naked mole-rat Rasa1 (101713771), cow RASA1 (282032), domestic guinea pig Rasa1 (100726441), dog RASA1 (479158), sheep RASA1 (101119216), chicken RASA1 (427327)
UniProtKB ID:
基因ID:
- Human(5921) Summary: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]
- Mouse(218397) RAS p21 protein activator 1
- Rat(25676) RAS p21 protein activator (GTPase activating protein) 1
- domestic cat(101095151) RAS p21 protein activator (GTPase activating protein) 1
- naked mole-rat(101713771) RAS p21 protein activator (GTPase activating protein) 1
- cow(282032) RAS p21 protein activator (GTPase activating protein) 1
- domestic guinea pig(100726441) RAS p21 protein activator (GTPase activating protein) 1
- dog(479158) RAS p21 protein activator (GTPase activating protein) 1
- sheep(101119216) RAS p21 protein activator (GTPase activating protein) 1
- chicken(427327) RAS p21 protein activator (GTPase activating protein) 1
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
产品编号
说明
物种反应性
应用
Anti-RASA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunohistochemistry
Anti-RASA1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunohistochemistry
Monoclonal Anti-RASA1, (C-terminal) antibody produced in mouse, clone 1E6, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
KD-Validated Anti RAS p21 protein activator 1 Antibody, clone 23GB4125, Rabbit Monoclonal, clone 23GB4125, recombinant rabbit monoclonal, expressed in HEK293 cells,
物种反应性
human, rat
应用
western blot