文件

164739

(+)-S-三苯甲基-L-半胱氨酸

97%

所有图片(1)

别名:

S-三苯甲基-L-半胱氨酸

线性分子式:

(C₆H₅)₃CSCH₂CH(NH₂)CO₂H

CAS号:

2799-07-7

分子量:

363.47

Beilstein/REAXYS Number:

2339626

MDL编号:

MFCD00002611

eCl@ss:

32160406

PubChem化学物质编号:

24850097

NACRES:

NA.22

质量水平

100

测定

97%

旋光性

[α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl

reaction suitability

reaction type: solution phase peptide synthesis

应用

peptide synthesis: suitable

mp

182-183 °C (dec.) (lit.)

SMILES string

N[C@@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)C(O)=O

InChI

1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1

InChI key

DLMYFMLKORXJPO-FQEVSTJZSA-N

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包装

5 g in glass bottle

应用

用于肽合成的保护性半胱氨酸。

象形图

GHS07

警示用语：

Warning

危险声明

H302

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

更多文件

Structure Search

FT-IR Condensed Phase

Spectra for FT-IR Raman

化学品安全说明书

Bulk Quote-Order Product

Optimized S-trityl-L-cysteine-based inhibitors of kinesin spindle protein with potent in vivo antitumor activity in lung cancer xenograft models.

James A D Good et al.

Journal of medicinal chemistry, 56(5), 1878-1893 (2013-02-12)

The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-L-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved potency, favorable drug-like properties, but...

Proteome analysis of apoptosis signaling by S-trityl-L-cysteine, a potent reversible inhibitor of human mitotic kinesin Eg5.

Frank Kozielski et al.

Proteomics, 8(2), 289-300 (2008-01-11)

Mitotic kinesins represent potential drug targets for anticancer chemotherapy. Inhibitors of different chemical classes have been identified that target human Eg5, a kinesin responsible for the establishment of the bipolar spindle. One potent Eg5 inhibitor is S-trityl-L-cysteine (STLC), which arrests...

Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation.

Jenna L Riffell et al.

Cell cycle (Georgetown, Tex.), 8(18), 3025-3038 (2009-08-29)

Microtubule-targeting cancer therapies interfere with mitotic spindle dynamics and block cells in mitosis by activating the mitotic checkpoint. Cells arrested in mitosis may remain arrested for extended periods of time or undergo mitotic slippage and enter interphase without having separated...

Inhibition of hepatitis C virus NS5B polymerase by S-trityl-L-cysteine derivatives.

Daniel B Nichols et al.

European journal of medicinal chemistry, 49, 191-199 (2012-01-28)

Structure-based studies led to the identification of a constrained derivative of S-trityl-l-cysteine (STLC) scaffold as a candidate inhibitor of hepatitis C virus (HCV) NS5B polymerase. A panel of STLC derivatives were synthesized and investigated for their activity against HCV NS5B....

Molecular dissection of the inhibitor binding pocket of mitotic kinesin Eg5 reveals mutants that confer resistance to antimitotic agents.

Sébastien Brier et al.

Journal of molecular biology, 360(2), 360-376 (2006-06-20)

The mitotic kinesin Eg5 plays an essential role in establishing the bipolar spindle. Recently, several antimitotic inhibitors have been shown to share a common binding region on Eg5. Considering the importance of Eg5 as a potential drug target for cancer...

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