CN

164739

Sigma-Aldrich

(+)-S-三苯甲基-L-半胱氨酸

97%

别名:
S-三苯甲基-L-半胱氨酸
线性分子式:
(C6H5)3CSCH2CH(NH2)CO2H
CAS号:
分子量:
363.47
Beilstein/REAXYS Number:
2339626
MDL编号:
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.22

质量水平

100

测定

97%

旋光性

[α]25/D +115°, c = 0.8 in 0.04 M ethanolic HCl

reaction suitability

reaction type: solution phase peptide synthesis

应用

peptide synthesis: suitable

mp

182-183 °C (dec.) (lit.)

SMILES string

N[C@@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)C(O)=O

InChI

1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1

InChI key

DLMYFMLKORXJPO-FQEVSTJZSA-N

正在寻找类似产品? Visit 产品对比指南

包装

5 g in glass bottle

应用

用于肽合成的保护性半胱氨酸。

象形图

Exclamation mark

警示用语:

Warning

危险声明

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

RIDADR

NONH for all modes of transport

WGK Germany

WGK 3

闪点(F)

Not applicable

闪点(C)

Not applicable

分析证书

原产地证书 (CofO)

James A D Good et al.
Journal of medicinal chemistry, 56(5), 1878-1893 (2013-02-12)
The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously, we identified S-trityl-L-cysteine as a selective inhibitor of Eg5 and developed triphenylbutanamine analogues with improved potency, favorable drug-like properties, but...
Frank Kozielski et al.
Proteomics, 8(2), 289-300 (2008-01-11)
Mitotic kinesins represent potential drug targets for anticancer chemotherapy. Inhibitors of different chemical classes have been identified that target human Eg5, a kinesin responsible for the establishment of the bipolar spindle. One potent Eg5 inhibitor is S-trityl-L-cysteine (STLC), which arrests...
Jenna L Riffell et al.
Cell cycle (Georgetown, Tex.), 8(18), 3025-3038 (2009-08-29)
Microtubule-targeting cancer therapies interfere with mitotic spindle dynamics and block cells in mitosis by activating the mitotic checkpoint. Cells arrested in mitosis may remain arrested for extended periods of time or undergo mitotic slippage and enter interphase without having separated...
Daniel B Nichols et al.
European journal of medicinal chemistry, 49, 191-199 (2012-01-28)
Structure-based studies led to the identification of a constrained derivative of S-trityl-l-cysteine (STLC) scaffold as a candidate inhibitor of hepatitis C virus (HCV) NS5B polymerase. A panel of STLC derivatives were synthesized and investigated for their activity against HCV NS5B....
Sébastien Brier et al.
Journal of molecular biology, 360(2), 360-376 (2006-06-20)
The mitotic kinesin Eg5 plays an essential role in establishing the bipolar spindle. Recently, several antimitotic inhibitors have been shown to share a common binding region on Eg5. Considering the importance of Eg5 as a potential drug target for cancer...

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门

社交媒体

WeChat Icon
Bilibili Icon

默克

研究、开发、生产

作为生命科学行业的全球领先供应商,我们致力于为研究、生物技术开发和生产,以及制药药物疗法开发和生产提供各类解决方案和服务。

© 2021 Merck KGaA, Darmstadt, Germany and/or its affiliates. 保留所有权利。

严格禁止在未经同意的情况下转载本网站之所有信息。 Sigma-Aldrich品牌产品均由Sigma-Aldrich LLC.独家贩售。