42995
反式-1,3-二苯基-2,3-环氧丙-1-酮
≥98.0%
别名:
反式-2-苯甲酰基-3-苯基环氧乙烷, 反式-亚苄基乙酰苯氧化物
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关于此项目
经验公式（希尔记法）:
C15H12O2
化学文摘社编号:
分子量:
224.25
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
84132
Assay:
≥98.0%
Form:
solid
InChI
1S/C15H12O2/c16-13(11-7-3-1-4-8-11)15-14(17-15)12-9-5-2-6-10-12/h1-10,14-15H/t14-,15-/m1/s1
SMILES string
O=C([C@H]1O[C@@H]1c2ccccc2)c3ccccc3
InChI key
UQGMJZQVDNZRKT-HUUCEWRRSA-N
assay
≥98.0%
form
solid
mp
86-89 °C (lit.)
functional group
ether, ketone, phenyl
General description
trans-1,3-Diphenyl-2,3-epoxypropan-1-one has been reported to efficiently participate in gas-phase Meerwein reaction under both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) conditions. Therapeutic potential of trans-1,3-diphenyl-2,3-epoxypropane-1-one (DPEP), and its anti-inflammatory effects have been studied.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Haiyong Han et al.
Archiv der Pharmazie, 343(8), 429-439 (2010-08-21)
Safe and effective chemotherapeutic agents for the treatment of pancreatic cancer remain elusive. We found that chalcone epoxides (1,3-diaryl-2,3-epoxypropanones) inhibited growth in two pancreatic cancer cell lines, BxPC-3 and MIA PaCa-2. Three compounds were active, with GI(50) values of 5.6
Yoshio Itoh et al.
Plant & cell physiology, 43(5), 578-585 (2002-06-01)
In the "Rhapsody" cultivar of the carnation, which bears white flowers variegated with red flecks and sectors, a transposable element, dTdic1, belonging to the Ac/Ds superfamily, was found within the dihydroflavonol 4-reductase (DFR) gene. The red flecks and sectors of
A D Marshall et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 30(6), 467-473 (1992-06-01)
The effect of modulating epoxide metabolism by inhibiting microsomal and cytosolic epoxide hydrolases and depleting glutathione, on the cytotoxicity of trans-anethole has been examined in freshly isolated rat hepatocytes in suspension. Hepatocytes derived from female Sprague-Dawley CD rats by collagenase
Chalcone oxides--potent selective inhibitors of cytosolic epoxide hydrolase.
C A Mullin et al.
Archives of biochemistry and biophysics, 216(2), 423-439 (1982-07-01)
E C Dietze et al.
Biochemical pharmacology, 42(6), 1163-1175 (1991-08-22)
The inhibition of murine cytosolic epoxide hydrolase has been studied with both racemic and enantiomerically pure trans-3-phenylglycidols. These compounds are the first enantioselective, slow binding inhibitors of cytosolic epoxide hydrolase. The (2S,3S)-3-phenylglycidol enantiomer was always a better inhibitor than the
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