574759
顺-四氯二氨铂(IV)
99.9% trace metals basis
别名:
cis -Diamminetetrachloroplatinum, cis-Tetrachlorodiammineplatinum
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关于此项目
线性分子式:
Pt(NH3)2Cl4
化学文摘社编号:
分子量:
370.95
EC 号:
MDL编号:
UNSPSC代码:
12352302
PubChem化学物质编号:
NACRES:
NA.23
方案
99.9% trace metals basis
表单
powder
mp
>300 °C (lit.)
SMILES字符串
N.N.Cl[Pt](Cl)(Cl)Cl
InChI
1S/4ClH.2H3N.Pt/h4*1H;2*1H3;/q;;;;;;+4/p-4
InChI key
RBHOYUZKIANPPG-UHFFFAOYSA-J
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警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
A C Plooy et al.
Cancer research, 44(5), 2043-2051 (1984-05-01)
Several effects of four diamminechloroplatinum compounds (II and IV) in Chinese hamster ovary cells were studied. The two cis-compounds [cis-diamminedichloroplatinum(II) and cis-diamminetetrachloroplatinum(IV)] are known to possess antitumor activity, whereas the two trans-stereoisomers [trans-diamminedichloroplatinum(II) and trans-diamminetetrachloroplatinum(IV)] are inactive. When the effects
M Defais et al.
Chemico-biological interactions, 74(3), 343-352 (1990-01-01)
DNA strand breaks were observed in bacteria treated with Pt(IV) but not Pt(II) antitumor compounds by two methods. First, compounds which cause DNA strand breaks produced an SOS induction signal which was detected by a rapid bacterial assay. In addition
H Razaka et al.
Chemico-biological interactions, 60(2), 207-215 (1986-11-01)
After exposure of bacteria to equal concentrations of cis-diamminedichloroplatinum(II) (DDP) and cis-diamminetetrachloroplatinum(IV) (DTP), the intracellular concentration of DTP was an order of magnitude greater than DDP. However, at identical intracellular drug concentrations, the Pt(IV) compound formed only half as many
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