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描述
Dehydroepiandrosterone sulfate (sodium salt)
检测方案
>99% (TLC)
形式
powder
包装
pkg of 1 × 10 mg (700086P-10mg)
pkg of 1 × 25 mg (700086P-25mg)
pkg of 1 × 50 mg (700086P-50mg)
制造商/商品名称
Avanti Research™ - A Croda Brand
运输
dry ice
储存温度
−20°C
InChI
1S/C19H28O5S/c1-18-9-7-13(24-25(21,22)23)11-12(18)3-4-14-15-5-6-17(20)19(15,2)10-8-16(14)18/h3,13-16H,4-11H2,1-2H3,(H,21,22,23)/t13-,14-,15-,16-,18-,19-/m0/s1
InChI key
CZWCKYRVOZZJNM-USOAJAOKSA-N
一般描述
DHEA 硫酸盐是脱氢表雄酮（DHEA）的一种代谢产物，通过硫酸转移酶 SULT1A1 和 SULT1E1 催化添加硫酸基团产生，这些酶也催化从雌酮产生硫酸雌酮。DHEA 硫酸盐也可以通过类固醇硫酸酯酶的作用转化回 DHEA。
脱氢表雄酮(DHEA)是一种肾上腺类固醇，广泛存在于人体内。它是DHAE的硫酸酯，由肾上腺和生殖腺合成。DHEAS在网狀带中产生。
应用
使用硫酸DHEA：
- 作为硫酸类固醇，以趋化性测定骨髓(BM)嗜中性粒细胞并检测其对RAC特异性鸟嘌呤核苷酸交换因子的抑制作用(Rac GEF)
- 在质谱分析法中用作内标物
- 用作合成脂质标准物，以在液相色谱-质谱分析(LC-MS)中加入低密度脂蛋白(LDL)样本
生化/生理作用
硫酸脱氢表雄酮(DHEA)(DHEAS)可调节儿茶酚胺的合成。它可调节神经递质受体，包括γ-氨基丁酸A型受体(GABAA)和 N-甲基-D -天冬氨酸(NMDA)受体。在阿尔茨海默病(AD)′患者的大脑中可发现到低水平的DHAES。
包装
5 mL 琥珀色玻璃螺旋盖小瓶（700086P-10mg）
5 mL 琥珀色玻璃螺旋盖小瓶（700086P-25mg）
5 mL 琥珀色玻璃螺旋盖小瓶（700086P-50mg）
法律信息
Avanti Research is a trademark of Avanti Polar Lipids, LLC
通常也和此产品一起购买
储存分类代码
11 - Combustible Solids
法规信息
监管及禁止进口产品
Ana Reis et al.
Journal of lipid research, 54(7), 1812-1824 (2013-05-15)
Lipidome profile of fluids and tissues is a growing field as the role of lipids as signaling molecules is increasingly understood, relying on an effective and representative extraction of the lipids present. A number of solvent systems suitable for lipid
Marco Racchi et al.
CNS drug reviews, 9(1), 21-40 (2003-02-22)
The physiological role of dehydroepiandrosterone (DHEA) and its sulphated ester DHEA(S) has been studied for nearly 2 decades and still eludes final clarification. The major interest in DHEA derives from its unique pattern of activity. Its levels exhibit a dramatic
Joseph S Dillon
Current drug targets. Inflammation and allergy, 4(3), 377-385 (2005-08-17)
Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) are metabolic intermediates in the production of potent androgens, estrogens and other less well-characterized steroids. DHEA(S) and closely related steroid hormones have a variety of immunological effects both in vitro and in vivo in
P Ebeling et al.
Lancet (London, England), 343(8911), 1479-1481 (1994-06-11)
Dehydroepiandrosterone (DHEA), with its sulphate conjugate (DHEAS), is the most abundant steroid hormone in the circulation but its physiological importance is unclear. We propose that DHEA has either oestrogen-like or androgen-like effects depending on the hormonal milieu. In premenopausal women
Kuei-Fang Chung et al.
Molecular and cellular endocrinology, 336(1-2), 141-148 (2010-12-07)
Dehydroepiandrosterone producing adrenocortical zona reticularis and the adrenal medulla are in direct contact and are highly intermingled in many species. This results in potentially strong paracrine influences of high local dehydroepiandrosterone concentrations on the adrenal medulla. Dehydroepiandrosterone has neuroprotective properties
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