01930
腺苷 5′-单磷酸 二钠盐
≥99.0% (HPLC)
别名:
5′-AMP二钠盐,, 腺苷酸二钠盐, 5′-AMP-Na2
生物来源
microbial (Candida utilis)
synthetic
质量水平
方案
≥99.0% (HPLC)
表单
powder
旋光性
[α]20/D −43±2°, c = 1% in 0.5 M Na2HPO4 (dry matter)
杂质
≤26% water
SMILES字符串
[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O
[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H]3O
InChI
1S/C10H14N5O7P.2Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1
InChI key
QGXLVXZRPRRCRP-IDIVVRGQSA-L
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应用
5′-单磷酸腺苷二钠盐已用于：
- 作为可溶性有机磷（DOP）化合物，以研究在大肠杆菌裂解物中的水解速率
- 诱导Fura2成骨细胞（C2-OB）钙反应
- 在分离、培养和鉴定胶质瘤干细胞（GSC）的培养基中作为核苷酸代谢物
腺苷5′-一磷酸（5′-AMP）在自然界中具有许多用途。5′-AMP是一类蛋白激酶[AMP活化蛋白激酶（AMPK）]的激活剂。它可以用作多种酶的底物，如AMP-胸苷激酶(EC 2.7.1.114)、AMP脱氨酶(EC 3.5.4.6)和5′-核苷酸酶(EC 3.1.3.5)。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Xiaoyu Xu et al.
Cell death & disease, 12(3), 277-277 (2021-03-17)
Glioma stem cells (GSCs) contribute to therapy resistance and poor outcomes for glioma patients. A significant feature of GSCs is their ability to grow in an acidic microenvironment. However, the mechanism underlying the rewiring of their metabolism in low pH
Nicholas Mikolajewicz et al.
Biophysical journal, 116(10), 2009-2022 (2019-05-06)
The skeleton constantly interacts and adapts to the physical world. We have previously reported that physiologically relevant mechanical forces lead to small repairable membrane injuries in bone-forming osteoblasts, resulting in release of ATP and stimulation of purinergic (P2) calcium responses
Aric H Mine et al.
Frontiers in microbiology, 12, 641700-641700 (2021-04-27)
The availability of phosphorus limits primary production in large regions of the oceans, and marine microbes use a variety of strategies to overcome this limitation. One strategy is the production of alkaline phosphatase (APase), which allows hydrolysis of larger dissolved
5′-AMP-activated protein kinase is inactivated by adrenergic signalling in adult cardiac myocytes.
Tsuchiya Y, Denison FC, et al.
Bioscience Reports, 32(2), 197-213 (2011)
Jiahuan Liu et al.
Scientific reports, 10(1), 21811-21811 (2020-12-15)
The present study was conducted to estimate the effects of dietary carbohydrates on muscle quality and the underlying mechanisms. Six isonitrogenous and isolipidic diets were formulated to contain graded levels of carbohydrates (0%, 8%, 12%, 16%, 20% and 24%, respectively).
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