Quality Level
assay
99%
form
solid
bp
113 °C/700 mmHg (lit.)
mp
36-41 °C (lit.)
functional group
amide
SMILES string
O=CNC1CCCCC1
InChI
1S/C7H13NO/c9-6-8-7-4-2-1-3-5-7/h6-7H,1-5H2,(H,8,9)
InChI key
SWGXDLRCJNEEGZ-UHFFFAOYSA-N
Gene Information
human ... ADH1A(124), ADH1B(125), ADH1C(126), ADH4(127), ADH7(131), EPHX2(2053)
mouse ... Ephx2(13850)
General description
N-Cyclohexylformamide binds to the complex of horse liver alcohol dehydrogenase with NADH and is similar to the Michaelis complex for aldehyde reduction catalyzed by the enzyme. It is formed during hydration of cyclohexyl isocyanide catalyzed by a novel enzyme isonitrile hydratase from Pseudomonas putida N19-2 .
Application
N-Cyclohexylformamide was used in the synthesis of 2-methylidene-1,3-selenazolidine derivatives.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
>235.4 °F - closed cup
flash_point_c
> 113 °C - closed cup
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
H Deng et al.
Biochemistry, 37(40), 14267-14278 (1998-10-07)
The binding of N-cyclohexylformamide (CXF) to the complex of horse liver alcohol dehydrogenase with NADH mimics that of the Michaelis complex for aldehyde reduction catalyzed by the enzyme. The Raman spectra of bound CXF and its 13C- and 15N-substituted derivatives
Selenium-containing heterocycles from isoselenocyanates: synthesis of 2-methylidene-1, 3-selenazolidine derivatives.
Sommen GL, et al.
Tetrahedron, 62(14), 3344-3354 (2006)
S Ramaswamy et al.
Biochemistry, 36(12), 3522-3527 (1997-03-25)
Amides are analogs of aldehydes and potent inhibitors of liver alcohol dehydrogenases. They can be used for structural studies and for inhibiting the metabolism of alcohols that form toxic products. We studied N-alkyl amides that bind to the enzyme-NADH complex
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 120685-25G | 04061831818406 |