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Merck
CN

128724

7-羟基-4-甲基香豆素

97%

别名:

4-MU, 4-甲基伞形酮, 香豆素 4

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经验公式(希尔记法):
C10H8O3 · H2O
化学文摘社编号:
分子量:
194.18
UNSPSC Code:
12352103
EC Number:
201-986-7
Beilstein/REAXYS Number:
142217
MDL number:
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SMILES string

CC1=CC(=O)Oc2cc(O)ccc12

assay

97%

mp

188.5-190 °C (lit.)

λmax

≤221 nm

Application

荧光测定酶活性的标准品。
适于用作激光染料

Other Notes

This product has been replaced by M1381-ALDRICH | 4-Methylumbelliferone ≥98%

存储类别

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

新产品
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分析证书(COA)

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K Takagaki et al.
Journal of biochemical and biophysical methods, 19(2-3), 207-214 (1989-08-01)
The present paper describes a fluorometric assay for galactosaminoglycan-degrading endo-beta-xylosidase, utilizing glycosaminoglycan chains bearing a 4-methylumbelliferyl group at the reducing terminus as a substrate. This fluorogenic substrate is synthesized by human skin fibroblasts cultured in the presence of a fluorogenic
Yuan Shi et al.
Bioorganic & medicinal chemistry letters, 21(3), 956-960 (2011-01-11)
A series of new coumarin-based 1,2,4-triazole derivatives were designed, synthesized and evaluated for their antimicrobial activities in vitro against four Gram-positive bacteria (Staphylococcus aureus, MRSA, Bacillus subtilis and Micrococcus luteus), four Gram-negative bacteria (Escherichia coli, Proteus vulgaris, Salmonella typhi and
Sergio A Rodríguez et al.
Bioorganic & medicinal chemistry, 19(21), 6233-6238 (2011-10-04)
The antioxidant activity of 4-hydroxycoumarin synthetic derivatives and 4-methylumbelliferone were determined taking 4-hydroxycoumarin as the reference compound. Six 3-aryl-4-hydroxycoumarin derivatives were synthesized from 4-hydroxycoumarin as precursor in order to evaluate changes in their antioxidant properties due to C3-aryl substituent nature.
Laura Piccagli et al.
Bioorganic & medicinal chemistry, 18(23), 8341-8349 (2010-10-29)
In the present study, a structured-based virtual screening (VS) of differently substituted furocoumarins and analogues has been carried out against nuclear factor kappa B (NF-κB), with the objective of selecting molecules able to inhibit the binding of this transcription factor
Koichiro Harada et al.
Bioorganic & medicinal chemistry letters, 20(1), 272-275 (2009-12-04)
The synthesis and SAR studies of 3- and 4-substituted 7-hydroxycoumarins as novel 17beta-HSD3 inhibitors are discussed. The most potent compounds from this series exhibited low nanomolar inhibitory activity with acceptable selectivity versus other 17beta-HSD isoenzymes and nuclear receptors.

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