130079
甲基三苯基溴化膦
98%
别名:
TPMP, Triphenylmethylphosphonium bromide, triphenylmethylphosphonium bromide
质量水平
方案
98%
表单
powder
反应适用性
reaction type: C-C Bond Formation
mp
230-234 °C (lit.)
官能团
phosphine
SMILES字符串
[Br-].C[P+](c1ccccc1)(c2ccccc2)c3ccccc3
InChI
1S/C19H18P.BrH/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19;/h2-16H,1H3;1H/q+1;/p-1
InChI key
LSEFCHWGJNHZNT-UHFFFAOYSA-M
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应用
Wittig 烯化盐，最近用于合成烯炔，通过关环复分解反应生成苯并氮杂卓环系。
广泛应用于通过 Wittig 反应的亚甲基化作用
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Aquatic Chronic 2
储存分类代码
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
闪点(°F)
>464.0 °F
闪点(°C)
> 240 °C
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Meredith F Ross et al.
The Biochemical journal, 411(3), 633-645 (2008-02-26)
Mitochondria-targeted molecules comprising the lipophilic TPP (triphenylphosphonium) cation covalently linked to a hydrophobic bioactive moiety are used to modify and probe mitochondria in cells and in vivo. However, it is unclear how hydrophobicity affects the rate and extent of their
Meredith F Ross et al.
The Biochemical journal, 400(1), 199-208 (2006-09-05)
Lipophilic monocations can pass through phospholipid bilayers and accumulate in negatively-charged compartments such as the mitochondrial matrix, driven by the membrane potential. This property is used to visualize mitochondria, to deliver therapeutic molecules to mitochondria and to measure the membrane
M P Murphy
Expert opinion on biological therapy, 1(5), 753-764 (2001-12-01)
Mitochondrial dysfunction causes or exacerbates a number of diseases. These include genetic disorders such as Friedreich's ataxia where the primary lesion is a defect in a nuclear gene and those diseases caused by mutations to mitochondrial DNA. Mitochondrial damage also
I Madar et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 40(7), 1180-1185 (1999-07-15)
In vitro studies have demonstrated the membrane potential-dependent enhanced uptake of phosphonium salts, including [3H]triphenylmethylphosphonium (TPMP), into mitochondria of carcinoma and glioma-derived tumor cells, suggesting the potential use of phosphonium salts as tracers for tumor imaging. This study characterizes the
Geoffrey F Kelso et al.
Annals of the New York Academy of Sciences, 959, 263-274 (2002-04-27)
Mitochondrial-targeted antioxidants that selectively block mitochondrial oxidative damage and prevent some types of cell death have been developed. These antioxidants are ubiquinone and tocopherol derivatives and are targeted to mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation. Because of
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