方案
98%
mp
90-92 °C (lit.)
SMILES字符串
COc1ccc2cc[nH]c2c1
InChI
1S/C9H9NO/c1-11-8-3-2-7-4-5-10-9(7)6-8/h2-6,10H,1H3
InChI key
QJRWYBIKLXNYLF-UHFFFAOYSA-N
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应用
6-甲氧基吲哚可用于在酸中研究血清素和其他相关化合物质子激发态形式的荧光。它用于制备：
- 色氨酸双加氧酶抑制剂吡啶基-乙烯基-吲哚，潜在的抗癌免疫调节剂
- 吲哚基吲唑和吲哚基吡唑吡啶，白介素-2诱导型T细胞激酶抑制剂
- 二吲哚基氧基吲哚，抗癌剂
- 苯甲酰基哌嗪基吲哚基乙烷二酮衍生物，HIV-1抑制剂
- 3-芳酰基吲哚，抗癌剂
- 吲哚基和异喹啉基的邻氨苯甲酸，PPARδ部分激动剂
- 杂芳基酮，VEGFR-2抑制剂
- 作为反应物，用于制备色氨酸双加氧酶抑制剂吡啶基-乙烯基-吲哚——一种潜在的抗癌免疫调节剂
- 作为反应物，用于合成吲哚基吲唑和吲哚基吡唑吡啶，作为白介素-2诱导型T细胞激酶抑制剂
- 作为反应物制备抗癌剂二吲哚基氧基吲哚
- 作为反应物制备苯甲酰基哌嗪基吲哚基乙烷二酮衍生物，作为HIV-1抑制剂
- 作为反应物制备抗癌剂3-芳酰基吲哚
- 作为反应物制备吲哚基和异喹啉基的邻氨苯甲酸，作为PPARδ部分激动剂
- 作为反应物制备杂芳基酮，作为VEGFR-2抑制剂
生化/生理作用
6-甲氧基吲哚抑制髓过氧化物酶的氯化活性，并抑制活化白细胞的次氯酸产生。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
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Hypochlorous acid (HOCl) released by activated leukocytes has been implicated in the tissue damage that characterizes chronic inflammatory diseases. In this investigation, 14 indole derivatives, including metabolites such as melatonin, tryptophan and indole-3-acetic acid, were screened for their ability to
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Bioorganic & medicinal chemistry letters, 20(17), 5229-5231 (2010-08-03)
A simple and highly efficient method has been developed for the synthesis of 3,3-diindolyl oxyindoles by the reaction of indoles with isatin or 5-fluoro isatin using a catalytic amount (5 mol%) of FeCl(3) at room temperature in a short reaction
Eugene L Piatnitski Chekler et al.
Bioorganic & medicinal chemistry letters, 18(15), 4344-4347 (2008-07-22)
We have discovered novel inhibitors of VEGFR-2 kinase with low nanomolar potency in both enzymatic and cell-based assays. Active series are heteroaryl-ketone compounds containing a central aromatic ring with either an indazolyl or indolyl keto group in the ortho orientation
Matthias Herdemann et al.
Bioorganic & medicinal chemistry letters, 20(23), 6998-7003 (2010-10-23)
A series of novel compound libraries inhibiting interleukin-2 inducible T cell kinase (ITK) were designed, synthesized and evaluated. In the first design cycle two library scaffolds were identified showing low micromolar inhibition of ITK. Further iterative design cycles including crystal
Fluorescence of protonated excited-state forms of 5-hydroxytryptamine (serotonin) and related indoles.
R F Chen
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